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PLD1 [tertiary granule membrane]
Stable Identifier
R-HSA-6800955
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
tertiary granule membrane
Synonyms
Phospholipase D1, PLD1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)
PLD1 [tertiary granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13393 PLD1
Gene Names
PLD1
Chain
chain:1-1074
Reference Genes
BioGPS Gene:5337 PLD1
COSMIC (genes):PLD1 PLD1
CTD Gene:5337 PLD1
dbSNP Gene:5337 PLD1
ENSEMBL:ENSG00000075651 PLD1
HGNC:9067 PLD1
KEGG:hsa:5337 PLD1
Monarch:5337 PLD1
NCBI Gene:5337 PLD1
OMIM:602382 PLD1
UCSC:Q13393 PLD1
Reference Transcript
RefSeq:NM_002662.4 PLD1
RefSeq:XM_011512897.1 PLD1
RefSeq:XM_005247533.2 PLD1
RefSeq:XM_005247534.2 PLD1
Other Identifiers
11723545_a_at
11723546_s_at
11737322_a_at
1557126_PM_a_at
1557126_a_at
16961551
177_PM_at
177_at
205203_PM_at
205203_at
215723_PM_s_at
215723_s_at
215724_PM_at
215724_at
226636_PM_at
226636_at
232530_PM_at
232530_at
2705444
2705446
2705447
2705448
2705449
2705450
2705451
2705453
2705455
2705456
2705458
2705459
2705465
2705466
2705468
2705473
2705475
2705476
2705481
2705482
2705483
2705484
2705487
2705488
2705490
2705491
2705492
2705493
2705496
2705498
2705500
2705501
2705504
2705505
2705506
2705507
2705508
2705509
2705510
2705511
2705512
2705513
2705514
2705515
2705521
2705522
2705523
2705524
2705525
2705526
2705527
2705528
2705529
2705532
2705533
5337
71119_at
8092134
89866_at
A_19_P00319323
A_19_P00319324
A_19_P00320889
A_19_P00321032
A_19_P00321033
A_19_P00321578
A_23_P155335
A_23_P398774
A_24_P123190
A_32_P112331
A_33_P3320062
GE81176
GO:0000139
GO:0003824
GO:0004630
GO:0005515
GO:0005737
GO:0005765
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006629
GO:0006654
GO:0006935
GO:0007264
GO:0007265
GO:0008289
GO:0009395
GO:0016020
GO:0016042
GO:0016324
GO:0016787
GO:0030139
GO:0031410
GO:0031670
GO:0031902
GO:0032534
GO:0035091
GO:0035556
GO:0035579
GO:0043226
GO:0043231
GO:0045727
GO:0048471
GO:0060627
GO:0070821
GO:0098693
GO:0098981
HMNXSV003044645
Hs.212533.0.S1_3p_at
Hs.82587.1.S1_3p_at
Hs.93837.2.A1_3p_at
Hs2.193001.1.S1_3p_s_at
ILMN_1719696
ILMN_1759344
PH_hs_0024328
TC03002001.hg
U38545_at
g4505872_3p_s_at
Participates
as a member of
Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)
Other forms of this molecule
PLD1 [specific granule membrane]
PLD1 [plasma membrane]
PLD1 [endoplasmic reticulum membrane]
Inferred To
Homologues of PLD1 [tertiary granule membrane]
(Dictyostelium discoideum)
SPO14 [tertiary granule membrane]
(Saccharomyces cerevisiae)
pld1 [tertiary granule membrane]
(Schizosaccharomyces pombe)
pld1 [tertiary granule membrane]
(Xenopus tropicalis)
pldC [tertiary granule membrane]
(Dictyostelium discoideum)
pldA [tertiary granule membrane]
(Dictyostelium discoideum)
Pld [tertiary granule membrane]
(Drosophila melanogaster)
pld-1 [tertiary granule membrane]
(Caenorhabditis elegans)
PLD1 [tertiary granule membrane]
(Bos taurus)
PLD1 [tertiary granule membrane]
(Canis familiaris)
PLD1 [tertiary granule membrane]
(Dictyostelium discoideum)
PLD1 [tertiary granule membrane]
(Gallus gallus)
PLD1 [tertiary granule membrane]
(Sus scrofa)
Pld1 [tertiary granule membrane]
(Mus musculus)
Pld1 [tertiary granule membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_005247591.1
,
XP_005247590.1
,
NP_002653.1
,
XP_011511199.1
ZINC - World Drugs
PLD1_HUMAN
Guide to Pharmacology - Targets
1433
ENSEMBL
ENSP00000348681
,
ENST00000356327
,
ENST00000351298
,
ENSP00000342793
OpenTargets
ENSG00000075651
ZINC - FDA approved
PLD1_HUMAN
ZINC - Substances
PLD1_HUMAN
ZINC target
Q13393
PRO
Q13393
GlyGen
Q13393
PDB
6U8Z
IntEnz
3.1.4.4
HPA
ENSG00000075651-PLD1
Pharos - Targets
Q13393
ZINC - Predictions - Purchasable
PLD1_HUMAN
HMDB Protein
HMDBP00082
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.571
4
UniProt:Q6NXG1 ESRP1
3
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
ESRP1 [nucleoplasm]
(R-HSA-6803472)
0.556
3
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q12888 TP53BP1
3
TP53BP1 [nucleoplasm]
(R-HSA-61175)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
0.556
3
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