Reactome | KPNB1 [ficolin-1-rich granule lumen]

KPNB1 [ficolin-1-rich granule lumen]

Stable Identifier

R-HSA-6800978

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule lumen

Synonyms

Importin beta-1, Karyopherin beta

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q14974 KPNB1

Gene Names

KPNB1, NTF97

Chain

chain:1-876

Reference Genes

BioGPS Gene:3837 KPNB1

COSMIC (genes):KPNB1 KPNB1

CTD Gene:3837 KPNB1

dbSNP Gene:3837 KPNB1

ENSEMBL:ENSG00000108424 KPNB1

ENSEMBL_homo_sapiens_GENE:ENSG00000108424.11 KPNB1

HGNC:6400 KPNB1

KEGG Gene (Homo sapiens):3837 KPNB1

Monarch:3837 KPNB1

NCBI Gene:3837 KPNB1

OMIM:602738 KPNB1

UCSC:Q14974 KPNB1

Reference Transcript

Other Identifiers

11743115_a_at

11743116_s_at

11744839_a_at

11744840_s_at

11764036_s_at

16835272

208974_PM_x_at

208974_x_at

208975_3p_s_at

208975_PM_s_at

208975_s_at

213507_3p_s_at

213507_PM_s_at

213507_s_at

213573_PM_at

213573_at

213574_PM_s_at

213574_s_at

213803_PM_at

213803_at

3078596

3535992

3724783

3724784

3724785

3724786

3724787

3724788

3724790

3724793

3724796

3724797

3724798

3724799

3724801

3724803

3724805

3724806

3724807

3724808

3724810

3724811

3724812

3724816

3724817

3724818

3724820

3724821

3724822

3724823

3837

41196_at

47013_at

75097_at

8007992

A_14_P139719

A_23_P118774

A_24_P73920

A_33_P3390441

GE81135

GO:0000278

GO:0003723

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0006404

GO:0006606

GO:0006607

GO:0006610

GO:0006886

GO:0006913

GO:0007010

GO:0007018

GO:0007059

GO:0007079

GO:0007080

GO:0008139

GO:0008270

GO:0010494

GO:0015031

GO:0016020

GO:0019899

GO:0019904

GO:0030953

GO:0031267

GO:0031410

GO:0031965

GO:0032991

GO:0035580

GO:0040001

GO:0042564

GO:0043226

GO:0051879

GO:0061608

GO:0061676

GO:0070062

GO:0071782

GO:0090307

GO:0140014

GO:0140104

GO:1904813

HMNXSV003043958

Hs.180446.1.A1_3p_a_at

Hs.180446.1.A1_3p_x_at

Hs.180446.2.A1_3p_a_at

Hs.180446.4.A1_3p_a_at

Hs.180446.4.A1_3p_x_at

ILMN_1703949

L38951_at

PH_hs_0027469

TC17000611.hg

g13097743_3p_s_at

g893287_3p_a_at

g893287_3p_s_at

Participates

as a member of

Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)

Other forms of this molecule

KPNB1 [specific granule lumen]

KPNB1 [extracellular region]

KPNB1 [nucleoplasm]

KPNB1 [cytosol]

Inferred To

KPNB1 [ficolin-1-rich granule lumen] (Bos taurus)

KPNB1 [ficolin-1-rich granule lumen] (Canis familiaris)

KPNB1 [ficolin-1-rich granule lumen] (Gallus gallus)

KPNB1 [ficolin-1-rich granule lumen] (Plasmodium falciparum)

KPNB1 [ficolin-1-rich granule lumen] (Sus scrofa)

kap95 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

kpnb1 [ficolin-1-rich granule lumen] (Xenopus tropicalis)

Fs(2)Ket [ficolin-1-rich granule lumen] (Drosophila melanogaster)

Kpnb1 [ficolin-1-rich granule lumen] (Mus musculus)

Kpnb1 [ficolin-1-rich granule lumen] (Rattus norvegicus)

KAP95 [ficolin-1-rich granule lumen] (Saccharomyces cerevisiae)

imb-1 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001263382.1, NP_002256.2

OpenTargets

ENSG00000108424

HPA

ENSG00000108424-KPNB1

GeneCards

Q14974

Ensembl

ENST00000535458, ENSP00000464042, ENSP00000290158, ENSP00000438964, ENST00000290158, ENST00000583648, ENSP00000438253, ENSG00000108424, ENST00000540627

PRO

Q14974

Pharos - Targets

Q14974

HMDB Protein

HMDBP08462

PDB

1M5N, 1QGR, 6N88, 3W5K, 1F59, 1O6P, 2Q5D, 6N89, 1O6O, 8GCN, 2QNA, 2P8Q, 1IBR, 3LWW, 1QGK

Interactors (58)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.935	14
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.821	9
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.8	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.774	24
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.759	5
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.725	6
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.725	5
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.688	4
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.688	4
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.643	5
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.643	4
UniProt:P18754 RCC1	2	RCC1 [nucleoplasm] (R-HSA-180690) RCC1 [chromosome] (R-HSA-9668547)	0.643	3
UniProt:P14907	1	NSP1 [nuclear envelope] (R-SCE-157713)	0.623	2
UniProt:P03101 VL1			0.623	2
UniProt:P51178 PLCD1	1	PLCD1 [plasma membrane] (R-HSA-2023880)	0.602	4
UniProt:P04620 REV			0.576	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	11
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.567	14
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.527	3
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.527	2
UniProt:Q69YH5 CDCA2			0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9BW19 KIFC1	1	KIFC1 [cytosol] (R-HSA-990500)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	6
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:O95373 IPO7			0.527	3
UniProt:A8CG34 POM121C	1	POM121C [nuclear envelope] (R-HSA-6805165)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q5SSJ5 HP1B3			0.527	2
UniProt:O15297 PPM1D	1	PPM1D [nucleoplasm] (R-HSA-2562518)	0.527	2
UniProt:P61769 B2M	11	B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.527	4
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	3
UniProt:P49792 RANBP2	6	polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) RANBP2 [nuclear envelope] (R-HSA-2993756) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2 [cytosol] (R-HSA-157703)	0.527	2
UniProt:Q86VU5 CMTD1			0.527	2
UniProt:P43487 RANBP1	1	RANBP1 [nuclear envelope] (R-HSA-167651)	0.527	3
UniProt:Q8N1F7 NUP93	2	NUP93 [nuclear envelope] (R-HSA-157749) NUP93 [cytosol] (R-HSA-9634167)	0.527	2
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.527	2
UniProt:O15355 PPM1G			0.527	2
UniProt:Q9BXS6 NUSAP			0.527	2
UniProt:Q9NPC8 SIX2	1	SIX2 [nucleoplasm] (R-HSA-9831037)	0.527	3
UniProt:Q8K4J6	3	Mrtfa [nucleoplasm] (R-MMU-3900216) Mrtfa [nucleoplasm] (R-MMU-3900220) Mrtfa [cytosol] (R-MMU-5665975)	0.525	2
UniProt:Q16637-3 SMN1			0.524	5
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [specific granule membrane] (R-HSA-6799569)	0.508	2
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.499	2
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.499	2
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.499	2
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.499	4
UniProt:B3CRR2 B3CRR2			0.499	2
UniProt:Q9WMX2 POLG			0.499	2
UniProt:F5H1C8 F5H1C8			0.499	2
UniProt:Q9Y275 TNFSF13B	1	sBAFF [extracellular region] (R-HSA-5676541)	0.499	2
UniProt:Q4G0J3 LARP7			0.483	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P07910 HNRNPC	3	HNRNPC [cytosol] (R-HSA-9715136) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [nucleoplasm] (R-HSA-71933)	0.483	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
UniProt:Q8IUH3 RBM45			0.462	2

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