Reactome | SERPINA3 [secretory granule lumen]

SERPINA3 [secretory granule lumen]

Stable Identifier

R-HSA-6801018

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Alpha-1-antichymotrypsin, AACT_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01011 SERPINA3

Gene Names

SERPINA3, AACT, GIG24, GIG25

Chain

signal peptide:1-23, chain:24-423, chain:26-423

Reference Genes

BioGPS Gene:12 SERPINA3

COSMIC (genes):SERPINA3 SERPINA3

CTD Gene:12 SERPINA3

dbSNP Gene:12 SERPINA3

ENSEMBL:ENSG00000196136 SERPINA3

HGNC:16 SERPINA3

KEGG:hsa:12 SERPINA3

Monarch:12 SERPINA3

NCBI Gene:12 SERPINA3

OMIM:107280 SERPINA3

UCSC:P01011 SERPINA3

Reference Transcript

RefSeq:NM_001085.4 SERPINA3

Other Identifiers

11716490_a_at

11716491_s_at

16787902

202376_PM_at

202376_at

33825_at

3549763

3549764

3549766

3549767

3549768

3549769

3549770

3549771

3549772

3549774

3549775

3549776

3549777

3549778

3549779

3549780

3549781

3549783

3549784

3549785

3549786

3549787

3549788

3549789

3577743

3577745

75248_at

7976496

A_14_P115578

A_14_P134662

A_14_P135079

A_23_P162918

A_23_P2920

A_33_P3399788

GE61869

GE85529

GO:0003677

GO:0004867

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0006953

GO:0006954

GO:0019216

GO:0022600

GO:0030277

GO:0030312

GO:0031012

GO:0031093

GO:0034774

GO:0035578

GO:0043226

GO:0062023

GO:0070062

GO:0072562

GO:0098772

HMNXSV003027949

ILMN_1788874

PH_hs_0040345

TC14002309.hg

X68733_rna1_at

g9665246_3p_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

SERPINA3 [platelet alpha granule lumen]

SERPINA3 [azurophil granule lumen]

SERPINA3 [extracellular region]

Inferred To

serpina3m [secretory granule lumen] (Xenopus tropicalis)

Spn42Dd [secretory granule lumen] (Drosophila melanogaster)

srp-8 [secretory granule lumen] (Caenorhabditis elegans)

Spn53F [secretory granule lumen] (Drosophila melanogaster)

serpina3 [secretory granule lumen] (Xenopus tropicalis)

Acp76A [secretory granule lumen] (Drosophila melanogaster)

Spn28Da [secretory granule lumen] (Drosophila melanogaster)

srp-1 [secretory granule lumen] (Caenorhabditis elegans)

Spn42Dc [secretory granule lumen] (Drosophila melanogaster)

Spn43Ab [secretory granule lumen] (Drosophila melanogaster)

Spn75F [secretory granule lumen] (Drosophila melanogaster)

Spn28Db [secretory granule lumen] (Drosophila melanogaster)

Spn38F [secretory granule lumen] (Drosophila melanogaster)

srp-2 [secretory granule lumen] (Caenorhabditis elegans)

srp-6 [secretory granule lumen] (Caenorhabditis elegans)

Spn85F [secretory granule lumen] (Drosophila melanogaster)

Spn88Eb [secretory granule lumen] (Drosophila melanogaster)

Serpina3f [secretory granule lumen] (Mus musculus)

Spn28B [secretory granule lumen] (Drosophila melanogaster)

Spn28F [secretory granule lumen] (Drosophila melanogaster)

Spn42Db [secretory granule lumen] (Drosophila melanogaster)

LOC100156325 [secretory granule lumen] (Sus scrofa)

SERPINA3 [secretory granule lumen] (Bos taurus)

SERPINA3 [secretory granule lumen] (Caenorhabditis elegans)

SERPINA3 [secretory granule lumen] (Canis familiaris)

Spn55B [secretory granule lumen] (Drosophila melanogaster)

Dmel\CG43366 [secretory granule lumen] (Drosophila melanogaster)

Spn47C [secretory granule lumen] (Drosophila melanogaster)

si:ch211-186e20.7 [secretory granule lumen] (Danio rerio)

srp-3 [secretory granule lumen] (Caenorhabditis elegans)

srp-7 [secretory granule lumen] (Caenorhabditis elegans)

Spn27A [secretory granule lumen] (Drosophila melanogaster)

Spn42De [secretory granule lumen] (Drosophila melanogaster)

Spn43Ad [secretory granule lumen] (Drosophila melanogaster)

Homologues of SERPINA3 [secretory granule lumen] (Caenorhabditis elegans)

Homologues of SERPINA3 [secretory granule lumen] (Drosophila melanogaster)

Homologues of SERPINA3 [secretory granule lumen] (Xenopus tropicalis)

Spn88Ea [secretory granule lumen] (Drosophila melanogaster)

nec [secretory granule lumen] (Drosophila melanogaster)

Spn31A [secretory granule lumen] (Drosophila melanogaster)

Spn100A [secretory granule lumen] (Drosophila melanogaster)

Spn43Aa [secretory granule lumen] (Drosophila melanogaster)

Spn42Da [secretory granule lumen] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000393080, ENSP00000450540, ENST00000393078, ENST00000556968, ENSP00000376795, ENSP00000376793, ENSP00000452476, ENST00000467132

OpenTargets

ENSG00000196136

HPA

ENSG00000196136-SERPINA3

PRO

P01011

Pharos - Targets

P01011

GlyGen

P01011

Orphanet

SERPINA3

PDB

6HGE, 1QMN, 1AS4, 2ACH, 4CAA, 3CAA, 3DLW

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.527	2

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