Reactome | PTPRB [tertiary granule membrane]

PTPRB [tertiary granule membrane]

Stable Identifier

R-HSA-6801032

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule membrane

Synonyms

RPTPbeta, Receptor-type tyrosine-protein phosphatase beta, PTPRB_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P23467 PTPRB

Gene Names

PTPRB, PTPB

Chain

signal peptide:1-22, chain:23-1997

Reference Genes

BioGPS Gene:5787 PTPRB

COSMIC (genes):PTPRB PTPRB

CTD Gene:5787 PTPRB

dbSNP Gene:5787 PTPRB

ENSEMBL:ENSG00000127329 PTPRB

ENSEMBL_homo_sapiens_GENE:ENSG00000127329.16 PTPRB

HGNC:9665 PTPRB

KEGG Gene (Homo sapiens):5787 PTPRB

Monarch:5787 PTPRB

NCBI Gene:5787 PTPRB

OMIM:176882 PTPRB

UCSC:P23467 PTPRB

Reference Transcript

Other Identifiers

11733229_a_at

11733230_a_at

11733231_a_at

11752192_x_at

16767422

205846_PM_at

205846_at

217177_PM_s_at

217177_s_at

230250_PM_at

230250_at

33066_at

3461796

3461797

3461798

3461799

3461800

3461801

3461802

3461803

3461804

3461805

3461809

3461812

3461813

3461815

3461816

3461817

3461820

3461823

3461824

3461826

3461827

3461828

3461831

3461832

3461833

3461834

3461838

3461839

3461840

3461841

3461842

3461843

3461844

3461845

3461848

3461850

3461851

3461852

3461855

3461859

3461862

3461866

3461868

3461869

3461874

3461875

3461876

3461877

3461878

3461879

37777_at

407_at

5787

7964872

A_23_P53390

A_24_P661612

A_32_P94851

GE56336

GE59789

GE874747

GO:0001525

GO:0003824

GO:0004721

GO:0004725

GO:0005001

GO:0005515

GO:0005886

GO:0006470

GO:0006796

GO:0008347

GO:0016020

GO:0016311

GO:0016787

GO:0016791

GO:0030154

GO:0031410

GO:0035579

GO:0036211

GO:0043226

GO:0043235

GO:0045296

GO:0048856

GO:0048870

GO:0060089

GO:0070821

GO:0140096

HMNXSV003020137

HMNXSV003034151

Hs.123641.1.A1_3p_at

Hs.149770.0.S1_3p_a_at

ILMN_1672102

ILMN_1821052

PH_hs_0025326

TC12001718.hg

X54131_at

g4506304_3p_at

Participates

as a member of

Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)

Other forms of this molecule

PTPRB [specific granule membrane]

PTPRB [plasma membrane]

Inferred To

PTPRB [tertiary granule membrane] (Bos taurus)

PTPRB [tertiary granule membrane] (Canis familiaris)

PTPRB [tertiary granule membrane] (Gallus gallus)

PTPRB [tertiary granule membrane] (Mus musculus)

PTPRB [tertiary granule membrane] (Sus scrofa)

Ptprb [tertiary granule membrane] (Rattus norvegicus)

ptprb [tertiary granule membrane] (Danio rerio)

Cross References

RefSeq

NP_002828.3, NP_001103224.1, NP_001193900.1, NP_001317133.1, NP_001193901.1

Guide to Pharmacology - Targets

1851

OpenTargets

ENSG00000127329

ZINC - Substances

PTPRB_HUMAN

ZINC target

P23467

PRO

P23467

PDB

2I5X, 2I3R, 2I4H, 2I4E, 2I3U, 2H04, 8JBY, 2H02, 2HC1, 2I4G, 8JBN, 2AHS, 2H03, 2HC2

HPA

ENSG00000127329-PTPRB

GeneCards

P23467

Ensembl

ENST00000550857, ENSP00000447302, ENSG00000127329, ENSP00000334928, ENSP00000438927, ENSP00000261266, ENST00000334414, ENST00000261266, ENST00000538708

Pharos - Targets

P23467

ZINC - Predictions - Purchasable

PTPRB_HUMAN

HMDB Protein

HMDBP08940

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	3
UniProt:P10912 GHR	7	p-Y332,Y487,Y627-GHR(19-638) [plasma membrane] (R-HSA-1169226) GHR(257-638) [plasma membrane] (R-HSA-1168803) p-5Y-GHR(19-638) [plasma membrane] (R-HSA-1168904) GHR(19-638) [endosome lumen] (R-HSA-1169263) GHR(19-256) [extracellular region] (R-HSA-1168821) GHR(19-638) [plasma membrane] (R-HSA-982779) GHR activated [plasma membrane] (R-HSA-1168385)	0.683	3
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.623	2

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