Reactome | PSMD6 [secretory granule lumen]

PSMD6 [secretory granule lumen]

Stable Identifier

R-HSA-6801036

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit S10, p42A, Proteasome regulatory particle subunit p44S10

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15008 PSMD6

Gene Names

PSMD6, KIAA0107, PFAAP4

Chain

initiator methionine:, chain:2-389

Reference Genes

BioGPS Gene:9861 PSMD6

COSMIC (genes):PSMD6 PSMD6

CTD Gene:9861 PSMD6

dbSNP Gene:9861 PSMD6

ENSEMBL:ENSG00000163636 PSMD6

HGNC:9564 PSMD6

KEGG:hsa:9861 PSMD6

Monarch:9861 PSMD6

NCBI Gene:9861 PSMD6

OMIM:617857 PSMD6

UCSC:Q15008 PSMD6

Reference Transcript

Other Identifiers

11731415_a_at

11746510_x_at

1555884_PM_at

1555884_at

16955771

202753_3p_at

202753_PM_at

202753_at

2679863

2679865

2679866

2679867

2679869

2679870

2679871

2679872

2679873

2679874

2679875

2679876

2679877

2679878

2679879

2679880

2679881

2679882

2679883

2679884

2679885

2679886

2679887

34680_s_at

8088535

9861

A_23_P109928

D14663_at

GE54973

GO:0000502

GO:0005515

GO:0005576

GO:0005654

GO:0005829

GO:0005838

GO:0022624

GO:0030163

GO:0032991

GO:0034774

GO:0043161

GO:1904813

HMNXSV003039793

Hs2.350939.1.A1_3p_at

ILMN_1779633

ILMN_2155998

PH_hs_0016942

TC03001522.hg

g7661913_3p_at

g7661913_3p_s_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

PSMD6 [cytosol]

PSMD6 [nucleoplasm]

PSMD6 [extracellular region]

PSMD6 [ficolin-1-rich granule lumen]

Inferred To

Rpn7 [secretory granule lumen] (Drosophila melanogaster)

rpn-7 [secretory granule lumen] (Caenorhabditis elegans)

PSMD6 [secretory granule lumen] (Bos taurus)

PSMD6 [secretory granule lumen] (Canis familiaris)

PSMD6 [secretory granule lumen] (Gallus gallus)

PSMD6 [secretory granule lumen] (Plasmodium falciparum)

PSMD6 [secretory granule lumen] (Sus scrofa)

Psmd6 [secretory granule lumen] (Mus musculus)

Psmd6 [secretory granule lumen] (Rattus norvegicus)

rpn7 [secretory granule lumen] (Schizosaccharomyces pombe)

psmd6 [secretory granule lumen] (Danio rerio)

psmd6 [secretory granule lumen] (Xenopus tropicalis)

RPN7 [secretory granule lumen] (Saccharomyces cerevisiae)

psmD6 [secretory granule lumen] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001258710.1, NP_055629.1, NP_001258709.1, NP_001258708.1

OpenTargets

ENSG00000163636

ENSEMBL

ENSP00000419227, ENSP00000418695, ENST00000295901, ENST00000394431, ENST00000482510, ENSP00000377952, ENSP00000295901, ENST00000492933

HPA

ENSG00000163636-PSMD6

PRO

Q15008

Pharos - Targets

Q15008

GlyGen

Q15008

PDB

5VFP, 7W3B, 7QXU, 6MSJ, 5T0H, 5VFQ, 7QXW, 7W39, 5T0C, 5L4K, 7W3G, 5T0I, 7W3A, 6MSB, 7W3I, 7QYA, 5VHI, 8CVT, 7W3K, 7W3M, 5GJQ, 7QXN, 7QXP, 6MSD, 5VFS, 6WJD, 5VHF, 5M32, 5T0G, 7W3H, 7W3J, 6MSK, 5VFU, 5LN3, 5VFR, 7W37, 6WJN, 5VHS, 6MSG, 5GJR, 5VGZ, 5T0J, 6MSH, 7W38, 5VHH, 7QXX, 7QY7, 7W3C, 7W3F, 7QYB, 5VFT

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.802	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	6
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.758	5
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.744	7
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.744	4
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.744	6
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.744	6
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.744	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.744	5
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.669	3
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.669	3
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.669	4
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.669	5
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	6
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.669	4
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.667	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.667	3
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	3
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.643	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.564	3
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.564	2
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.564	2
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.564	3
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.564	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.564	2
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.564	2
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.564	3
UniProt:P20133	2	RABGGTB [cytosol] (R-SCE-8870419) RABGGTB [plasma membrane] (R-SCE-6801098)	0.556	3
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.556	5
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9UMX0-2 UBQLN1			0.556	3
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	3
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.527	3
UniProt:Q53HC0 CCD92			0.527	3
UniProt:Q96G75 RMND5B	1	RMND5B [cytosol] (R-HSA-9861550)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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