Reactome | CHM [cytosol]

CHM [cytosol]

Stable Identifier

R-HSA-6801097

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Rab proteins geranylgeranyltransferase component A 1, REP1, Rab escort protein 1, TCD, Choroideremia protein

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        CHM binds RGGT (Homo sapiens)
        
        CHM [cytosol] (Homo sapiens)
        
        RGGT:CHM [plasma membrane] (Homo sapiens)
        
        CHM [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24386 CHM

Gene Names

CHM, REP1, TCD

Chain

chain:1-653

Reference Genes

BioGPS Gene:1121 CHM

COSMIC (genes):CHM CHM

CTD Gene:1121 CHM

dbSNP Gene:1121 CHM

ENSEMBL:ENSG00000188419 CHM

HGNC:1940 CHM

KEGG:hsa:1121 CHM

Monarch:1121 CHM

NCBI Gene:1121 CHM

OMIM:300390 CHM

UCSC:P24386 CHM

Reference Transcript

Other Identifiers

1121

11723471_a_at

11723472_a_at

11733638_at

11733639_a_at

1569183_PM_a_at

1569183_a_at

17112519

207099_PM_s_at

207099_s_at

227871_PM_at

227871_at

32867_at

4014252

4014253

4014254

4014255

4014256

4014258

4014259

4014261

4014262

4014264

4014265

4014266

4014267

4014273

4014274

4014275

4014276

4014277

4014279

4014280

4014282

4014283

4014284

4014290

4014291

4014295

4014296

4014297

4014298

59973_at

81325_at

8173892

A_23_P11144

A_23_P22548

A_33_P3274397

GE80007

GO:0003824

GO:0004663

GO:0005092

GO:0005096

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005968

GO:0006612

GO:0006886

GO:0007264

GO:0007601

GO:0016192

GO:0016740

GO:0018344

GO:0031267

GO:0043226

GO:0050877

GO:0098772

GO:0140096

HMNXSV003038537

HMNXSV003050168

Hs.13442.0.A1_3p_at

Hs.13442.0.A1_3p_x_at

Hs2.156730.1.S1_3p_s_at

ILMN_1709112

ILMN_1771238

PH_hs_0019624

PH_hs_0026173

PH_hs_0039955

TC0X001191.hg

X78121_at

g9966760_3p_a_at

Participates

as a member of

as a component of

RGGT:CHM [plasma membrane] (Homo sapiens)

as an input of

CHM binds RGGT (Homo sapiens)

Inferred To

MRS6 [cytosol] (Saccharomyces cerevisiae)

chm [cytosol] (Danio rerio)

chm [cytosol] (Xenopus tropicalis)

Chm [cytosol] (Mus musculus)

Chm [cytosol] (Rattus norvegicus)

CHM [cytosol] (Bos taurus)

CHM [cytosol] (Canis familiaris)

CHM [cytosol] (Dictyostelium discoideum)

CHM [cytosol] (Gallus gallus)

CHM [cytosol] (Plasmodium falciparum)

CHM [cytosol] (Schizosaccharomyces pombe)

CHM [cytosol] (Sus scrofa)

Rep [cytosol] (Drosophila melanogaster)

rep-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001138886.1, NP_000381.1, NP_001307888.1

OpenTargets

ENSG00000188419

ENSEMBL

ENSP00000350386, ENST00000357749, ENST00000615443, ENSP00000484306

HPA

ENSG00000188419-CHM

PRO

P24386

Pharos - Targets

P24386

Orphanet

CHM

GlyGen

P24386

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92696 RABGGTA	2	RABGGTA [plasma membrane] (R-HSA-6801086) RABGGTA [cytosol] (R-HSA-8870418)	0.744	6
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.671	5
UniProt:P51148 RAB5C	10	GGC-RAB5C [clathrin-coated endocytic vesicle membrane] (R-HSA-8871129) RAB5C [Golgi membrane] (R-HSA-434334) RAB5C [cytoplasmic vesicle membrane] (R-HSA-434198) RAB5C [early endosome membrane] (R-HSA-8854157) GGC-RAB5C [early endosome membrane] (R-HSA-8875331) GGC-RAB5C [cytosol] (R-HSA-8870436) RAB5C [cytosol] (R-HSA-8870413) GGC-RAB5C [macropinosome membrane] (R-HSA-9837694) RAB5C [plasma membrane] (R-HSA-6806265) RAB5C [azurophil granule membrane] (R-HSA-6799338)	0.643	4
UniProt:P51151 RAB9A	5	RAB9A [transport vesicle] (R-HSA-6814618) RAB9A [trans-Golgi network membrane] (R-HSA-6814616) GGC-RAB9A [trans-Golgi network membrane] (R-HSA-8876087) GGC-RAB9A [cytosol] (R-HSA-8874069) RAB9A [cytosol] (R-HSA-6813904)	0.615	5
UniProt:P26441 CNTF	1	CNTF [extracellular region] (R-HSA-5696441)	0.527	2
UniProt:Q9NP90 RAB9B	7	RAB9B [transport vesicle] (R-HSA-6814621) RAB9B [trans-Golgi network membrane] (R-HSA-6814620) GGC-RAB9B [trans-Golgi network membrane] (R-HSA-8876089) GGC-RAB9B [cytosol] (R-HSA-8874076) RAB9B [cytosol] (R-HSA-6813907) RAB9B [plasma membrane] (R-HSA-6804810) RAB9B [secretory granule membrane] (R-HSA-6804773)	0.527	4
UniProt:O14966 RAB29	2	RAB29 [cytosol] (R-HSA-8873713) GGC-RAB29 [cytosol] (R-HSA-8873957)	0.527	2
UniProt:Q6IQ22 RAB12	3	GGC-RAB12 [recycling endosome membrane] (R-HSA-8876449) GGC-RAB12 [cytosol] (R-HSA-8873777) RAB12 [cytosol] (R-HSA-8873672)	0.527	2
UniProt:P20336 RAB3A	9	RAB3A [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372512) RAB3A [plasma membrane] (R-HSA-210461) RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917743) RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210466) RAB3A [secretory granule membrane] (R-HSA-6804968) RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-379365) RAB3A [cytosol] (R-HSA-8870410) GGC-RAB3A [cytosol] (R-HSA-8870429) GGC-RAB3A [secretory granule membrane] (R-HSA-8875319)	0.527	3
UniProt:Q15907 RAB11B	3	RAB11B [recycling endosome membrane] (R-HSA-8854762) GGC-RAB11B [cytosol] (R-HSA-8873766) RAB11B [cytosol] (R-HSA-8873671)	0.527	4
UniProt:Q13636 RAB31	5	GGC-RAB31 [early endosome membrane] (R-HSA-8877278) GGC-RAB31 [cytosol] (R-HSA-8873974) RAB31 [cytosol] (R-HSA-8873690) RAB31 [plasma membrane] (R-HSA-6804813) RAB31 [secretory granule membrane] (R-HSA-6804797)	0.527	3
UniProt:Q9NRW1 RAB6B	6	RAB6B [endoplasmic reticulum membrane] (R-HSA-8849252) RAB6B [trans-Golgi network membrane] (R-HSA-6810985) RAB6B [Golgi membrane] (R-HSA-8849249) GGC-RAB6B [trans-Golgi network membrane] (R-HSA-8876081) GGC-RAB6B [cytosol] (R-HSA-8874055) RAB6B [cytosol] (R-HSA-6810983)	0.527	3
UniProt:Q13637 RAB32	3	GGC-RAB32 [melanosome membrane] (R-HSA-8877737) GGC-RAB32 [cytosol] (R-HSA-8873980) RAB32 [cytosol] (R-HSA-8873696)	0.527	4
UniProt:Q96AH8 RAB7B	4	RAB7B [late endosome membrane] (R-HSA-8854158) GGC-RAB7B [lysosomal membrane] (R-HSA-8877450) GGC-RAB7B [cytosol] (R-HSA-8874059) RAB7B [cytosol] (R-HSA-8873707)	0.527	3
UniProt:P62491 RAB11A	4	GGC-RAB11A [cytoplasmic vesicle membrane] (R-HSA-1458519) RAB11A [cytosol] (R-HSA-5623395) GGC-RAB11A [cytosol] (R-HSA-8873781) RAB11A [recycling endosome membrane] (R-HSA-2029023)	0.527	3
UniProt:P61026 RAB10	5	GGC-RAB10 [cytoplasmic vesicle membrane] (R-HSA-8876076) GGC-RAB10 [cytosol] (R-HSA-8873783) RAB10 [cytosol] (R-HSA-8873669) RAB10 [plasma membrane] (R-HSA-6804816) RAB10 [secretory granule membrane] (R-HSA-6804788)	0.527	3
UniProt:P62820 RAB1A	8	p-T195-RAB1A [Golgi membrane] (R-HSA-2172190) RAB1A [Golgi membrane] (R-HSA-2167938) RAB1A [cytosol] (R-HSA-5685725) RAB1A [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807766) RAB1A [transport vesicle] (R-HSA-6808796) GGC-RAB1A [cytosol] (R-HSA-8870424) GGC-RAB1A [transport vesicle membrane] (R-HSA-8877472) RAB1A [endoplasmic reticulum membrane] (R-HSA-6810974)	0.527	2
UniProt:Q9H0U4 RAB1B	8	RAB1B [endoplasmic reticulum membrane] (R-HSA-6810977) GGC-RAB1B [transport vesicle membrane] (R-HSA-8877470) GGC-RAB1B [cytosol] (R-HSA-8870426) RAB1B [transport vesicle] (R-HSA-6808799) RAB1B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807768) RAB1B [cytosol] (R-HSA-5685727) RAB1B [Golgi membrane] (R-HSA-2422381) p-T191-RAB1B [Golgi membrane] (R-HSA-2422374)	0.527	3
UniProt:Q15771 RAB30	3	RAB30 [Golgi membrane] (R-HSA-8849598) GGC-RAB30 [cytosol] (R-HSA-8873972) RAB30 [cytosol] (R-HSA-8873677)	0.527	3
UniProt:Q92930 RAB8B	4	RAB8B [recycling endosome membrane] (R-HSA-8854156) GGC-RAB8B [trans-Golgi network membrane] (R-HSA-8876084) GGC-RAB8B [cytosol] (R-HSA-8874068) RAB8B [cytosol] (R-HSA-8873697)	0.527	4
UniProt:Q9H0T7 RAB17	2	GGC-RAB17 [cytosol] (R-HSA-8873764) RAB17 [cytosol] (R-HSA-8873703)	0.527	2
UniProt:O00194 RAB27B	5	GGC-RAB27B [melanosome membrane] (R-HSA-8877280) GGC-RAB27B [cytosol] (R-HSA-8873786) RAB27B [cytosol] (R-HSA-8873706) RAB27B [plasma membrane] (R-HSA-8862952) RAB27B [platelet dense granule membrane] (R-HSA-8862955)	0.527	3

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