Reactome | RABGGTB [plasma membrane]

RABGGTB [plasma membrane]

Stable Identifier

R-HSA-6801098

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Geranylgeranyl transferase type-2 subunit beta, GGTB, Rab geranyl-geranyltransferase subunit beta

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Locations in the PathwayBrowser for interactor UniProt:Q9Y305 ACOT9

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        RABGGTA binds RABGGTB (Homo sapiens)
        
        RABGGTB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53611 RABGGTB

Gene Names

RABGGTB, GGTB

Chain

initiator methionine:, chain:2-331

Reference Genes

BioGPS Gene:5876 RABGGTB

COSMIC (genes):RABGGTB RABGGTB

CTD Gene:5876 RABGGTB

dbSNP Gene:5876 RABGGTB

ENSEMBL:ENSG00000137955 RABGGTB

HGNC:9796 RABGGTB

KEGG:hsa:5876 RABGGTB

Monarch:5876 RABGGTB

NCBI Gene:5876 RABGGTB

OMIM:179080 RABGGTB

UCSC:P53611 RABGGTB

Reference Transcript

RefSeq:NM_004582.3 RABGGTB

Other Identifiers

11724300_a_at

11757294_x_at

16666268

17118662

17118664

17118666

209180_PM_at

209180_at

209181_PM_s_at

209181_s_at

213704_PM_at

213704_at

2342622

2342623

2342625

2342627

2342628

2342629

2342630

2342631

2342632

2342633

2342634

2342635

2342636

2342637

2342638

2342639

2342640

2342641

2342642

2342643

2342644

2342645

2342646

2342647

2342648

2342649

2342650

2342651

2342652

2342653

2342654

2342655

2342656

2342658

2342659

2342660

2342662

37703_at

3983311

5876

781_at

7902382

7902396

7902398

7902400

A_14_P128168

A_21_P0000289

A_21_P0000372

A_23_P85371

A_24_P336705

A_33_P3311618

GE60250

GO:0003824

GO:0004659

GO:0004661

GO:0004663

GO:0005515

GO:0005829

GO:0005886

GO:0005968

GO:0007601

GO:0008270

GO:0008318

GO:0016740

GO:0018344

GO:0031267

GO:0036211

GO:0046872

GO:0050877

GO:0140096

HMNXSV003008566

HMNXSV003013751

HMNXSV003037933

ILMN_1790354

ILMN_2163796

PH_hs_0004556

RNA33617|snoRNA_scaRNA_213_83

RNA33668|snoRNA_scaRNA_264_78

TC01000777.hg

X98001_at

g1216503_3p_a_at

Participates

as a component of

RGGT [plasma membrane] (Homo sapiens)

as an input of

RABGGTA binds RABGGTB (Homo sapiens)

Other forms of this molecule

RABGGTB [cytosol]

Inferred To

rabggtb [plasma membrane] (Danio rerio)

RABGGTB [plasma membrane] (Bos taurus)

RABGGTB [plasma membrane] (Caenorhabditis elegans)

RABGGTB [plasma membrane] (Canis familiaris)

RABGGTB [plasma membrane] (Dictyostelium discoideum)

RABGGTB [plasma membrane] (Mus musculus)

RABGGTB [plasma membrane] (Plasmodium falciparum)

RABGGTB [plasma membrane] (Rattus norvegicus)

RABGGTB [plasma membrane] (Saccharomyces cerevisiae)

RABGGTB [plasma membrane] (Schizosaccharomyces pombe)

RabGGTb [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_004573.2

OpenTargets

ENSG00000137955

ENSEMBL

ENSP00000317473, ENST00000319942

IntEnz

2.5.1.60

HPA

ENSG00000137955-RABGGTB

PRO

P53611

Pharos - Targets

P53611

GlyGen

P53611

HMDB Protein

HMDBP11879

PDB

6O60, 6J7X, 6J6X, 6J74, 6J7F

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92696 RABGGTA	2	RABGGTA [plasma membrane] (R-HSA-6801086) RABGGTA [cytosol] (R-HSA-8870418)	0.8	8
UniProt:Q9UBV7 B4GALT7	4	B4GALT7 A186D [Golgi membrane] (R-HSA-3621785) B4GALT7 L206P [Golgi membrane] (R-HSA-3621790) B4GALT7 R270C [Golgi membrane] (R-HSA-3621734) B4GALT7 [Golgi membrane] (R-HSA-1889950)	0.718	6
UniProt:P57081 WDR4	1	WDR4 [nucleoplasm] (R-HSA-6782341)	0.718	6
UniProt:Q9Y3L5 RAP2C	2	RAP2C [plasma membrane] (R-HSA-6804983) RAP2C [tertiary granule membrane] (R-HSA-6804975)	0.643	3
UniProt:Q7Z6K3 PTAR1			0.643	4
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.569	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q7Z5A9 TAFA1			0.556	3
UniProt:Q86YD3 TMM25			0.556	3
UniProt:Q9UM47 NOTCH3	20	Ub-NICD3 [cytosol] (R-HSA-9021546) Ub-NEXT3 [plasma membrane] (R-HSA-9021545) p-Y-NICD3 [cytosol] (R-HSA-9018581) Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911429) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane] (R-HSA-1911419) NOTCH3(1572-2321) [Golgi membrane] (R-HSA-156995) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane] (R-HSA-1983672) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region] (R-HSA-1983675) NOTCH3(1572-2321) [plasma membrane] (R-HSA-157231) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane] (R-HSA-1472871) 14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467307) 10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane] (R-HSA-1467382) Pre-NOTCH3 [endoplasmic reticulum membrane] (R-HSA-157102) NICD3 [nucleoplasm] (R-HSA-157928) NICD3 [cytosol] (R-HSA-157647) NEXT3 [plasma membrane] (R-HSA-157203) NOTCH3(1629-1661) [plasma membrane] (R-HSA-157657) NOTCH3(40-1628) [extracellular region] (R-HSA-157639) FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane] (R-HSA-1911522) FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane] (R-HSA-1911517)	0.527	2
UniProt:O15498 YKT6	5	PalmC-YKT6 [Golgi membrane] (R-HSA-6808792) PalmC-YKT6 [transport vesicle] (R-HSA-6808794) PalmC-YKT6 [endoplasmic reticulum membrane] (R-HSA-5688145) PalmC-YKT6 [ER to Golgi transport vesicle membrane] (R-HSA-5688557) PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688558)	0.527	3
UniProt:Q12974 PTP4A2	1	FarC-PTP4A2 [cytosol] (R-HSA-8870421)	0.527	2
UniProt:P51151 RAB9A	5	RAB9A [transport vesicle] (R-HSA-6814618) RAB9A [trans-Golgi network membrane] (R-HSA-6814616) GGC-RAB9A [trans-Golgi network membrane] (R-HSA-8876087) GGC-RAB9A [cytosol] (R-HSA-8874069) RAB9A [cytosol] (R-HSA-6813904)	0.527	2
UniProt:Q6UWZ7 FAM175A	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.527	2
UniProt:Q96I34 PP16A			0.527	2
UniProt:Q96H79 ZCCHL			0.527	2
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) proHRAS [cytosol] (R-HSA-9647765) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS [plasma membrane] (R-HSA-62717) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.527	3
UniProt:Q9UKA4 AKA11			0.527	2
UniProt:A2A3N6 PIPSL			0.527	2
UniProt:P10114 RAP2A			0.527	3
UniProt:Q9UJC3 HOOK1			0.527	2
UniProt:Q6PGQ7 BORA	3	BORA [cytosol] (R-HSA-2562607) p-S252,S497,T501-BORA [cytosol] (R-HSA-3000330) p-S252-BORA [cytosol] (R-HSA-4086411)	0.527	2
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.527	3
UniProt:Q96QS6 PSKH2			0.527	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.527	2
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.527	2
UniProt:O60331 PIP5K1C	1	PIP5K1C [cytosol] (R-HSA-392427)	0.527	2
UniProt:Q8N414 PGBD5			0.527	2
UniProt:Q14642 INPP5A	1	INPP5A [plasma membrane] (R-HSA-1604583)	0.527	3
UniProt:Q9Y305 ACOT9	1	ACOT9 [mitochondrial matrix] (R-HSA-5690069)	0.527	2
UniProt:Q13636 RAB31	5	GGC-RAB31 [early endosome membrane] (R-HSA-8877278) GGC-RAB31 [cytosol] (R-HSA-8873974) RAB31 [cytosol] (R-HSA-8873690) RAB31 [plasma membrane] (R-HSA-6804813) RAB31 [secretory granule membrane] (R-HSA-6804797)	0.527	3
UniProt:Q9NRW1 RAB6B	6	RAB6B [endoplasmic reticulum membrane] (R-HSA-8849252) RAB6B [trans-Golgi network membrane] (R-HSA-6810985) RAB6B [Golgi membrane] (R-HSA-8849249) GGC-RAB6B [trans-Golgi network membrane] (R-HSA-8876081) GGC-RAB6B [cytosol] (R-HSA-8874055) RAB6B [cytosol] (R-HSA-6810983)	0.527	3
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.527	2
UniProt:Q93096 TP4A1			0.527	3
UniProt:Q12829 RAB40B	2	GGC-RAB40B [cytosol] (R-HSA-8874024) RAB40B [cytosol] (R-HSA-8873718)	0.527	3
UniProt:Q96AH8 RAB7B	4	RAB7B [late endosome membrane] (R-HSA-8854158) GGC-RAB7B [lysosomal membrane] (R-HSA-8877450) GGC-RAB7B [cytosol] (R-HSA-8874059) RAB7B [cytosol] (R-HSA-8873707)	0.527	2
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.527	3
UniProt:Q9BYB4 GNB1L			0.527	2
UniProt:Q96AX2 RAB37	5	GGC-RAB37 [cytosol] (R-HSA-8873996) RAB37 [cytosol] (R-HSA-8873678) RAB37 [specific granule membrane] (R-HSA-6799605) RAB37 [plasma membrane] (R-HSA-6799686) RAB37 [azurophil granule membrane] (R-HSA-6799607)	0.488	2

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