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RABGGTA binds RABGGTB
Stable Identifier
R-HSA-6801101
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
RABGGTA binds RABGGTB (Homo sapiens)
General
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RABGGTA associates with RABGGTB to form RAB geranylgeranyl transferase (RGGT or RAB GGTase). This was initially shown using proteins purified from rat brain (Seabra et al. 1992), but the complex is evolutionarily conserved in human cells (Baron and Seabra 2008).
Literature References
PubMed ID
Title
Journal
Year
1321151
Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys
Brown, MS
,
Goldstein, JL
,
Sudhof, TC
,
Seabra, MC
J. Biol. Chem.
1992
18532927
Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate
Seabra, MC
,
Baron, RA
Biochem. J.
2008
Participants
Input
RABGGTA [plasma membrane]
(Homo sapiens)
RABGGTB [plasma membrane]
(Homo sapiens)
Output
RGGT [plasma membrane]
(Homo sapiens)
Participates
as an event of
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
Orthologous Events
RABGGTA binds RABGGTB (Bos taurus)
RABGGTA binds RABGGTB (Caenorhabditis elegans)
RABGGTA binds RABGGTB (Canis familiaris)
RABGGTA binds RABGGTB (Danio rerio)
RABGGTA binds RABGGTB (Dictyostelium discoideum)
RABGGTA binds RABGGTB (Drosophila melanogaster)
RABGGTA binds RABGGTB (Mus musculus)
RABGGTA binds RABGGTB (Plasmodium falciparum)
RABGGTA binds RABGGTB (Rattus norvegicus)
RABGGTA binds RABGGTB (Saccharomyces cerevisiae)
RABGGTA binds RABGGTB (Schizosaccharomyces pombe)
Authored
Orlic-Milacic, M (2015-10-14)
Reviewed
Zaccara, S (2016-02-04)
Inga, A (2016-02-04)
Created
Orlic-Milacic, M (2015-09-30)
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