Reactome | CSNK2B [secretory granule lumen]

CSNK2B [secretory granule lumen]

Stable Identifier

R-HSA-6801319

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Casein kinase II beta subunit

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P67870 CSNK2B

Gene Names

CSNK2B, CK2N, G5A

Chain

initiator methionine:, chain:2-215

Reference Genes

BioGPS Gene:1460 CSNK2B

COSMIC (genes):CSNK2B CSNK2B

CTD Gene:1460 CSNK2B

dbSNP Gene:1460 CSNK2B

ENSEMBL:ENSG00000204435 CSNK2B

HGNC:2460 CSNK2B

KEGG:hsa:1460 CSNK2B

Monarch:1460 CSNK2B

NCBI Gene:1460 CSNK2B

OMIM:115441 CSNK2B

UCSC:P67870 CSNK2B

Reference Transcript

Other Identifiers

11723718_a_at

11737947_s_at

11745786_a_at

11747530_a_at

11757576_x_at

11760180_at

11760181_a_at

1460

17006763

17027898

17030721

17033428

17035519

17038221

17040816

201390_PM_s_at

201390_s_at

231777_PM_at

231777_at

2902560

2902561

2902562

2902563

2902564

2902565

2902566

2902567

2902568

2902569

2902570

2902571

2902572

2902573

2902575

2902576

2902577

2902578

2902579

2902581

2902582

2902583

2902584

410_s_at

55988_at

8118218

8118228

8178050

8178059

8179298

A_14_P200179

A_23_P59130

A_24_P804263

A_24_P97931

A_33_P3318027

GE59734

GE82605

GO:0000785

GO:0003682

GO:0003824

GO:0004674

GO:0005102

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005956

GO:0007165

GO:0008285

GO:0016055

GO:0016301

GO:0016605

GO:0016740

GO:0018107

GO:0019887

GO:0019904

GO:0030674

GO:0031519

GO:0032435

GO:0032927

GO:0033211

GO:0034774

GO:0042802

GO:0043226

GO:0043537

GO:0046872

GO:0051101

GO:0060090

GO:0060391

GO:0061154

GO:0061629

GO:0065003

GO:0070062

GO:0075342

GO:0098772

GO:0140096

GO:1903901

GO:1904813

HMNXSV003021467

HMNXSV003049073

Hs.73527.0.S2_3p_at

ILMN_1785527

ILMN_1800461

PH_hs_0022181

TC06004074.hg

TC6_cox_hap2000242.hg

TC6_cox_hap2000243.hg

TC6_dbb_hap3000219.hg

TC6_dbb_hap3000220.hg

TC6_mann_hap4000193.hg

TC6_mann_hap4000194.hg

TC6_mcf_hap5000210.hg

TC6_mcf_hap5000211.hg

TC6_qbl_hap6000222.hg

TC6_qbl_hap6000223.hg

TC6_ssto_hap7000196.hg

TC6_ssto_hap7000197.hg

X57152_rna1_s_at

g10334850_3p_s_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

CSNK2B [cytosol]

CSNK2B [nucleoplasm]

CSNK2B [extracellular region]

CSNK2B [ficolin-1-rich granule lumen]

Inferred To

CSNK2B [secretory granule lumen] (Bos taurus)

CSNK2B [secretory granule lumen] (Canis familiaris)

CSNK2B [secretory granule lumen] (Danio rerio)

CSNK2B [secretory granule lumen] (Mus musculus)

CSNK2B [secretory granule lumen] (Plasmodium falciparum)

CSNK2B [secretory granule lumen] (Rattus norvegicus)

CSNK2B [secretory granule lumen] (Sus scrofa)

CkIIbeta [secretory granule lumen] (Drosophila melanogaster)

kin-10 [secretory granule lumen] (Caenorhabditis elegans)

csnk2b [secretory granule lumen] (Dictyostelium discoideum)

csnk2b [secretory granule lumen] (Xenopus tropicalis)

ckb1 [secretory granule lumen] (Schizosaccharomyces pombe)

CKB2 [secretory granule lumen] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001311.3, NP_001269314.1

Guide to Pharmacology - Targets

1551

OpenTargets

ENSG00000204435

ENSEMBL

ENSP00000407018, ENSP00000407379, ENSP00000415237, ENSP00000409510, ENSP00000394855, ENST00000412802, ENSP00000400188, ENST00000454382, ENST00000400110, ENST00000448596, ENST00000429633, ENST00000452985, ENST00000383427, ENSP00000382980, ENST00000453234, ENST00000422567, ENSP00000410802, ENST00000458330, ENST00000455161, ENST00000383433, ENSP00000412520, ENSP00000372925, ENST00000418230, ENSP00000413469, ENSP00000365026, ENSP00000393756, ENSP00000415303, ENSP00000365025, ENSP00000365042, ENSP00000391038, ENST00000451917, ENST00000375882, ENST00000431476, ENST00000454511, ENST00000436169, ENSP00000372919, ENST00000443673, ENSP00000390900, ENST00000375865, ENST00000375866, ENSP00000411322, ENSP00000395275

HPA

ENSG00000204435-CSNK2B

PRO

P67870

Pharos - Targets

P67870

GlyGen

P67870

Orphanet

CSNK2B

HMDB Protein

HMDBP10475

PDB

4MD8, 4DGL, 4MD7, 6Q38, 4NH1, 3EED, 1JWH, 1DS5, 4MD9, 1QF8

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15418 RPS6KA1	7	p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) RPS6KA1 [cytosol] (R-HSA-444256) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860)	0.725	5
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.666	4
UniProt:O75582 RPS6KA5	3	p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (R-HSA-198683) RPS6KA5 [nucleoplasm] (R-HSA-198657) RPS6KA5 [cytosol] (R-HSA-772525)	0.659	3
UniProt:Q9WTL8 Arntl	4	Arntl [nucleoplasm] (R-MMU-9769624) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [cytosol] (R-MMU-508660) p-S-Arntl [nucleoplasm] (R-MMU-508690)	0.646	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	3
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.643	5
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.626	5
UniProt:Q6VY07 PACS1	1	PACS1 [cytosol] (R-HSA-167634)	0.593	3
UniProt:P97784 Cry1	4	ub-p-Cry1 [nucleoplasm] (R-MMU-517961) p-Cry1 [nucleoplasm] (R-MMU-508662) p-Cry1 [cytosol] (R-MMU-508644) Cry1 [cytosol] (R-MMU-508637)	0.592	2
UniProt:Q9UBS0 RPS6KB2	2	p-S15,S356-RPS6KB2 [nucleoplasm] (R-HSA-199844) RPS6KB2 [nucleoplasm] (R-HSA-199877)	0.589	3
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.547	2
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.527	2
UniProt:Q92794 KAT6A	3	KAT6A [nucleoplasm] (R-HSA-480310) p-T369-KAT6A [nucleoplasm] (R-HSA-6805633) KAT6A (1-1118) [nucleoplasm] (R-HSA-5603260)	0.527	2
UniProt:Q8WUQ7 CACTIN	1	CACTIN [nucleoplasm] (R-HSA-9769591)	0.527	3
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.527	3
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.527	2
UniProt:Q01831 XPC	5	monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub-XPC [nucleoplasm] (R-HSA-6782944) XPC [nucleoplasm] (R-HSA-67441)	0.527	2
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.527	3
UniProt:Q86US8 SMG6	1	SMG6 [cytosol] (R-HSA-927851)	0.527	2
UniProt:O08785 Clock	2	p-S-Clock [nucleoplasm] (R-MMU-508670) Clock [cytosol] (R-MMU-508720)	0.508	2

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