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PKM [ficolin-1-rich granule lumen]
Stable Identifier
R-HSA-6801387
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule lumen
Synonyms
Pyruvate kinase PKM ecNumber2.7.1.40/ecNumber, KPYM_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
PKM [ficolin-1-rich granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14618 PKM
Gene Names
PKM, OIP3, PK2, PK3, PKM2
Chain
initiator methionine:1, chain:2-531
Reference Genes
COSMIC (genes):PKM PKM
dbSNP Gene:5315 PKM
ENSEMBL:ENSG00000067225 PKM
Participates
as a member of
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
Other forms of this molecule
PKM [extracellular region]
PKM [secretory granule lumen]
PKM [nucleoplasm]
Inferred To
Dmel\CG11249 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
pyk-1 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Dmel\CG7362 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
pkma [ficolin-1-rich granule lumen]
(Danio rerio)
PKM [ficolin-1-rich granule lumen]
(Bos taurus)
PKM [ficolin-1-rich granule lumen]
(Dictyostelium discoideum)
PKM [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
PKM [ficolin-1-rich granule lumen]
(Gallus gallus)
PKM [ficolin-1-rich granule lumen]
(Mus musculus)
PKM [ficolin-1-rich granule lumen]
(Plasmodium falciparum)
PKM [ficolin-1-rich granule lumen]
(Saccharomyces cerevisiae)
PKM [ficolin-1-rich granule lumen]
(Schizosaccharomyces pombe)
PKM [ficolin-1-rich granule lumen]
(Sus scrofa)
Dmel\CG12229 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
pkm [ficolin-1-rich granule lumen]
(Xenopus tropicalis)
Pkml1 [ficolin-1-rich granule lumen]
(Rattus norvegicus)
pyk-2 [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Dmel\CG7069 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Dmel\CG2964 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Homologues of PKM [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
Homologues of PKM [ficolin-1-rich granule lumen]
(Danio rerio)
Homologues of PKM [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Homologues of PKM [ficolin-1-rich granule lumen]
(Plasmodium falciparum)
Homologues of PKM [ficolin-1-rich granule lumen]
(Saccharomyces cerevisiae)
pklr [ficolin-1-rich granule lumen]
(Danio rerio)
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
9
UniProt:P03129 VE7
0.646
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
20
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
p-6Y-FGFR3 A391E [plasma membrane]
(R-HSA-2065835)
p-6Y-FGFR3 K650T [plasma membrane]
(R-HSA-2032966)
p-6Y-FGFR3 G382D [plasma membrane]
(R-HSA-2032950)
p-6Y-FGFR3 G380R [plasma membrane]
(R-HSA-2032946)
p-6Y-FGFR3 K650M [plasma membrane]
(R-HSA-2032959)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q9WMX2 POLG
0.556
4
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:Q96IK1-2 Q96IK12
0.556
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.556
3
UniProt:P04020 VE7
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:P53355 DAPK1
1
DAPK1 [cytosol]
(R-HSA-418262)
0.524
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
0.524
4
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.519
2
UniProt:Q9BSI4 TINF2
1
TINF2 [nucleoplasm]
(R-HSA-174883)
0.508
2
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.499
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
3
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