Reactome | CSTB [secretory granule lumen]

CSTB [secretory granule lumen]

Stable Identifier

R-HSA-6801394

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Cystatin-B, CYTB_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04080 CSTB

Gene Names

CSTB, CST6, STFB

Chain

chain:1-98

Reference Genes

BioGPS Gene:1476 CSTB

COSMIC (genes):CSTB CSTB

CTD Gene:1476 CSTB

dbSNP Gene:1476 CSTB

ENSEMBL:ENSG00000160213 CSTB

ENSEMBL_homo_sapiens_GENE:ENSG00000160213.10 CSTB

HGNC:2482 CSTB

KEGG Gene (Homo sapiens):1476 CSTB

Monarch:1476 CSTB

NCBI Gene:1476 CSTB

OMIM:601145 CSTB

Reference Transcript

RefSeq:NM_000100.3 CSTB

Other Identifiers

11728320_a_at

11754056_x_at

11757287_x_at

11758318_s_at

1476

16926253

201201_PM_at

201201_at

35816_at

3934249

3934250

3934251

3934252

3934254

3934257

8070701

A_23_P154894

GE54961

GO:0002020

GO:0003723

GO:0004866

GO:0004869

GO:0005576

GO:0005615

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0008344

GO:0010466

GO:0030312

GO:0030414

GO:0031012

GO:0031410

GO:0034774

GO:0043226

GO:0045861

GO:0062023

GO:0070062

GO:0098772

GO:1904724

GO:1904813

GO:1990000

HMNXSV003016324

ILMN_1761797

PH_hs_0000080

U46692_rna1_at

g4503116_3p_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

CSTB [ficolin-1-rich granule lumen]

CSTB [extracellular region]

CSTB [tertiary granule lumen]

Inferred To

CSTB [secretory granule lumen] (Bos taurus)

CSTB [secretory granule lumen] (Canis familiaris)

CSTB [secretory granule lumen] (Gallus gallus)

CSTB [secretory granule lumen] (Sus scrofa)

Cstb [secretory granule lumen] (Mus musculus)

Cstb [secretory granule lumen] (Rattus norvegicus)

cpiB [secretory granule lumen] (Dictyostelium discoideum)

cpiC [secretory granule lumen] (Dictyostelium discoideum)

cpiA [secretory granule lumen] (Dictyostelium discoideum)

Homologues of CSTB [secretory granule lumen] (Danio rerio)

Homologues of CSTB [secretory granule lumen] (Dictyostelium discoideum)

Homologues of CSTB [secretory granule lumen] (Xenopus tropicalis)

LOC116408737 [secretory granule lumen] (Xenopus tropicalis)

cst14b.1 [secretory granule lumen] (Danio rerio)

cstb [secretory granule lumen] (Xenopus tropicalis)

cst14a.1 [secretory granule lumen] (Danio rerio)

cst14a.2 [secretory granule lumen] (Danio rerio)

Cross References

RefSeq

NP_000091.1

OpenTargets

ENSG00000160213

GeneCards

P04080

HPA

ENSG00000160213-CSTB

Ensembl

ENSP00000291568, ENST00000291568, ENSG00000160213

PRO

P04080

Pharos - Targets

P04080

Orphanet

15815

PDB

1STF, 4N6V, 2OCT

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	12

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