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PPIA [secretory granule lumen]
Stable Identifier
R-HSA-6801400
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Cyp A protein
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
PPIA [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62937 PPIA
Gene Names
PPIA, CYPA
Chain
chain:1-165, initiator methionine:, chain:2-165
Reference Genes
BioGPS Gene:5478 P629372
COSMIC (genes):PPIA PPIA
CTD Gene:5478 P629372
dbSNP Gene:5478 P629372
ENSEMBL:ENSG00000196262 PPIA
HGNC:9253 P629372
KEGG:hsa:5478 P629372
Monarch:5478 P629372
NCBI Gene:5478 P629372
OMIM:123840 P629372
UCSC:P62937 P629372
Reference Transcript
RefSeq:NM_001300981.1 P629372
RefSeq:NM_021130.4 P629372
Participates
as a member of
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
Other forms of this molecule
PPIA [cytosol]
PPIA [ficolin-1-rich granule lumen]
PPIA [extracellular region]
PPIA [extracellular exosome]
Inferred To
PPIA [secretory granule lumen]
(Bos taurus)
PPIA [secretory granule lumen]
(Caenorhabditis elegans)
PPIA [secretory granule lumen]
(Canis familiaris)
PPIA [secretory granule lumen]
(Gallus gallus)
PPIA [secretory granule lumen]
(Sus scrofa)
Ppia [secretory granule lumen]
(Mus musculus)
Ppia [secretory granule lumen]
(Rattus norvegicus)
ppiab [secretory granule lumen]
(Danio rerio)
Cyp1 [secretory granule lumen]
(Drosophila melanogaster)
ppia [secretory granule lumen]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2751
ENSEMBL
ENSP00000503804
,
ENST00000678789
,
ENST00000489459
,
ENSP00000502945
,
ENST00000677107
,
ENSP00000419425
,
ENST00000355968
,
ENST00000678805
,
ENST00000468812
,
ENSP00000430817
,
ENSP00000427976
,
ENSG00000196262
,
ENSP00000504216
,
ENST00000677022
,
ENSP00000504735
OpenTargets
ENSG00000196262
ZINC - Substances
PPIA_HUMAN
ZINC target
P62937
PRO
P62937
GlyGen
P62937
PDB
7PCJ
,
4N1Q
,
6GJL
,
5FJB
,
1M9F
,
6X4M
,
5NOS
,
1VBT
,
6GJY
,
5KV0
,
8TBL
,
6ZDJ
,
8G9Q
,
4YUH
,
7N9X
,
8TBI
,
2MZU
,
5KV1
,
6Y9X
,
7UXM
,
1AWS
,
5NOV
,
2ALF
,
1CWI
,
1AWU
,
3K0M
,
3K0Q
,
1CWL
,
9BG1
,
1CWO
,
1M9D
,
1OCA
,
6U5D
,
2X2D
,
7TA8
,
6X4Q
,
5T9W
,
6X4O
,
4N1N
,
2X2C
,
1W8M
,
6U5C
,
5NOT
,
9BFY
,
6GS6
,
1W8L
,
4YUG
,
4YUI
,
5NOQ
,
5KV5
,
5NOR
,
6GJI
,
2X25
,
8TBJ
,
5KUW
,
4N1O
,
6X3Y
,
8TBG
,
2RMA
,
7UPN
,
5T9Z
,
6GJJ
,
1RMH
,
1M9C
,
3K0O
,
1CWB
,
1AK4
,
5NOZ
,
6Y9V
,
1AWR
,
1CWH
,
1CWK
,
3K0N
,
3K0R
,
3RDD
,
1M63
,
1CWM
,
5TA4
,
1ZKF
,
5KUV
,
3ODI
,
4YUO
,
7QBW
,
8TBF
,
1MIK
,
5KUU
,
2MS4
,
5KUS
,
4YUM
,
6BTA
,
5KUQ
,
1M9E
,
4N1R
,
1VBS
,
4YUK
,
1M9X
,
6U5G
,
1W8V
,
2RMB
,
8G9P
,
5KUZ
,
5KUR
,
7UXN
,
1NMK
,
2XGY
,
7UXJ
,
5WC7
,
6Y9Y
,
3CYH
,
6Y9Z
,
9AX6
,
5NOW
,
5LUD
,
1CWF
,
1AWT
,
1CWJ
,
5NOY
,
1AWV
,
7ABT
,
1MF8
,
6X4P
,
8TBH
,
5T9U
,
5KV7
,
5KUN
,
5KV6
,
1BCK
,
3ODL
,
6GJN
,
5KV4
,
5NOU
,
8HZ8
,
5F66
,
6X4N
,
4CYH
,
4YUJ
,
5KV2
,
4N1S
,
4N1M
,
1M9Y
,
6X3R
,
6GJR
,
5KUO
,
8TBM
,
5KV3
,
4N1P
,
2CYH
,
8TBK
,
6I42
,
1CWA
,
5NOX
,
1CWC
,
3CYS
,
2CPL
,
3K0P
,
6Y9W
,
1AWQ
,
2N0T
,
6U5E
,
1FGL
,
6GJP
,
1YND
,
4YUP
,
5CYH
,
8TBN
,
5TA2
,
4YUL
,
5KUL
,
4IPZ
,
6GJM
,
4YUN
,
2X2A
HPA
ENSG00000196262-PPIA
GeneCards
PPIA
Pharos - Targets
P62937
ZINC - Predictions - Purchasable
PPIA_HUMAN
HMDB Protein
HMDBP10691
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.713
3
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.676
4
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.666
4
UniProt:Q72497 Q72497
0.623
7
UniProt:P46108-1 CRK
0.595
4
UniProt:Q99IB8-PRO_0000045602
0.59
2
UniProt:P35613 BSG
2
BSG [plasma membrane]
(R-HSA-197673)
BSG [Golgi membrane]
(R-HSA-204478)
0.589
2
UniProt:O14686 KMT2D
1
KMT2D [nucleoplasm]
(R-HSA-1183219)
0.558
2
UniProt:Q00535 CDK5
4
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [nucleoplasm]
(R-HSA-8863586)
0.556
3
UniProt:O75376 NCOR1
2
NCOR1 [nucleoplasm]
(R-HSA-442501)
NCOR1 [cytosol]
(R-HSA-1253310)
0.556
3
UniProt:O43614 HCRTR2
1
HCRTR2 [plasma membrane]
(R-HSA-389421)
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:P62841 RPS15
2
RPS15 [cytosol]
(R-HSA-72335)
RPS15 [nucleoplasm]
(R-HSA-6798706)
0.556
3
UniProt:O00429 DNM1L
2
DNM1L [cytosol]
(R-HSA-351943)
DNM1L [mitochondrial outer membrane]
(R-HSA-351942)
0.527
5
UniProt:Q13618 CUL3
3
CUL3 [cytosol]
(R-HSA-975979)
CUL3 [nucleoplasm]
(R-HSA-5635033)
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.508
2
UniProt:P0C6X7-PRO_0000037309 REP
0.508
4
UniProt:Q16849 PTPRN
0.508
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
UniProt:O95831 AIFM1
0.463
2
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