Reactome | PPIA [secretory granule lumen]

PPIA [secretory granule lumen]

Stable Identifier

R-HSA-6801400

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Cyp A protein

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P62937 PPIA

Gene Names

PPIA, CYPA

Chain

initiator methionine:1, chain:1-165, chain:2-165

Reference Genes

BioGPS Gene:5478 PPIA

COSMIC (genes):PPIA PPIA

CTD Gene:5478 PPIA

dbSNP Gene:5478 PPIA

ENSEMBL:ENSG00000196262 PPIA

ENSEMBL:ENSG00000196262.15 PPIA

HGNC:9253 PPIA

KEGG Gene (Homo sapiens):5478 PPIA

Monarch:5478 PPIA

NCBI Gene:5478 PPIA

OMIM:123840 PPIA

UCSC:P62937 PPIA

Reference Transcript

Other Identifiers

11725710_a_at

11725711_x_at

11725712_s_at

11752928_x_at

11758017_x_at

11758067_x_at

17045738

201293_3p_x_at

201293_PM_x_at

201293_x_at

211378_3p_x_at

211378_PM_x_at

211378_x_at

211765_3p_x_at

211765_PM_x_at

211765_x_at

211978_3p_x_at

211978_PM_x_at

211978_x_at

212661_3p_x_at

212661_PM_x_at

212661_x_at

226336_PM_at

226336_at

2567594

2567597

2675551

2898671

2898673

2898675

2949035

2949036

3000074

3000075

3000076

3000077

3000078

3000079

3000080

3000081

3000083

3000085

3000087

3000091

3000092

3000093

3000094

3000095

3000096

3000097

3062970

3295264

33667_at

3374006

3569637

3602437

3915708

5478

7919436

8067978

8132642

A_14_P113087

A_23_P258340

A_24_P920125

A_24_P95038

A_32_P68459

GE79899

GO:0000413

GO:0001933

GO:0001934

GO:0002376

GO:0003723

GO:0003755

GO:0003824

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005925

GO:0006351

GO:0006355

GO:0006457

GO:0006469

GO:0006807

GO:0006915

GO:0007155

GO:0012501

GO:0016018

GO:0016020

GO:0016853

GO:0019076

GO:0023052

GO:0030168

GO:0030593

GO:0030595

GO:0031410

GO:0031982

GO:0032148

GO:0032873

GO:0032991

GO:0034389

GO:0034599

GO:0034774

GO:0035307

GO:0036211

GO:0042060

GO:0042118

GO:0043170

GO:0043226

GO:0043410

GO:0044238

GO:0045069

GO:0045070

GO:0046790

GO:0048870

GO:0050714

GO:0051082

GO:0051092

GO:0060352

GO:0061944

GO:0070062

GO:0070527

GO:0140096

GO:1902176

GO:1903901

GO:1904399

GO:1904813

GO:2001233

HMNXSV003009370

HMNXSV003058305

Hs.182937.2.S1_3p_s_at

Hs.182937.3.A1_3p_at

Hs.267690.2.S1_3p_s_at

ILMN_1704529

PH_hs_0032846

TC07000278.hg

X52851_rna1_at

g10863926_3p_s_at

g12654762_3p_s_at

g13543665_3p_s_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

PPIA [extracellular exosome]

PPIA [extracellular region]

PPIA [ficolin-1-rich granule lumen]

PPIA [cytosol]

Inferred To

ppi1 [secretory granule lumen] (Schizosaccharomyces pombe)

CPR1 [secretory granule lumen] (Saccharomyces cerevisiae)

PPIA [secretory granule lumen] (Bos taurus)

PPIA [secretory granule lumen] (Caenorhabditis elegans)

PPIA [secretory granule lumen] (Canis familiaris)

PPIA [secretory granule lumen] (Danio rerio)

PPIA [secretory granule lumen] (Gallus gallus)

PPIA [secretory granule lumen] (Sus scrofa)

Ppia [secretory granule lumen] (Mus musculus)

Ppia [secretory granule lumen] (Rattus norvegicus)

BcDNA:AT31683 [secretory granule lumen] (Drosophila melanogaster)

CPR3 [secretory granule lumen] (Saccharomyces cerevisiae)

Homologues of PPIA [secretory granule lumen] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001287910.1, NP_066953.1

Guide to Pharmacology - Targets

2751

OpenTargets

ENSG00000196262

ZINC - Substances

PPIA_HUMAN

ZINC target

P62937

PRO

P62937

PDB

6GJM, 5NOU, 4N1Q, 1NMK, 6ZDJ, 6X3R, 4YUL, 5KUN, 1CWM, 5NOV, 7UXM, 5KUO, 1M9D, 6GJN, 5KV7, 1W8V, 4YUN, 2N0T, 4CYH, 6U5C, 4IPZ, 4N1N, 1CWB, 5NOR, 6X4O, 6U5G, 6X4N, 6GJI, 3RDD, 1AWS, 1MIK, 3K0P, 5KUZ, 5KV2, 5KV3, 5T9Z, 1CWL, 4N1S, 3CYH, 1ZKF, 1CWJ, 5FJB, 4YUM, 5NOY, 6BTA, 2CPL, 6GJY, 5KUS, 3CYS, 2RMA, 5TA2, 2XGY, 1W8M, 5NOQ, 2X2A, 5KUW, 6Y9W, 5WC7, 1AWT, 1M9X, 1VBS, 4YUH, 1RMH, 1OCA, 2X2C, 1YND, 3K0O, 4YUI, 6X4Q, 3ODL, 5NOT, 1AWQ, 6X4P, 5KUL, 7UXN, 6GJL, 1CWK, 4YUK, 6Y9Z, 3K0R, 7TA8, 1M9E, 7PCJ, 5NOW, 6GJR, 4YUO, 5KUQ, 1AK4, 5KV6, 1CWH, 6GJP, 6X3Y, 6U5D, 5CYH, 5NOZ, 7ABT, 5F66, 5KUR, 6Y9V, 1W8L, 6GS6, 4N1M, 1M9Y, 1CWC, 1FGL, 3ODI, 1CWA, 2CYH, 6U5E, 6X4M, 1MF8, 6GJJ, 7UXJ, 4N1P, 5NOS, 5T9W, 7QBW, 1AWR, 4YUJ, 1CWO, 5KV1, 7UPN, 4N1R, 3K0Q, 5KV4, 1M9F, 1M63, 6Y9Y, 5LUD, 1CWI, 2ALF, 1M9C, 5NOX, 5KV5, 1CWF, 1BCK, 2X25, 4YUP, 2RMB, 1AWV, 6I42, 5KUU, 7N9X, 5TA4, 3K0M, 4YUG, 6Y9X, 5KV0, 1VBT, 1AWU, 5KUV, 2MS4, 4N1O, 3K0N, 2MZU, 5T9U, 2X2D

GeneCards

P62937

HPA

ENSG00000196262-PPIA

Ensembl

ENSG00000196262, ENST00000678789, ENST00000355968, ENST00000468812, ENSP00000430817, ENSP00000427976, ENSP00000419425, ENSP00000504216, ENST00000677107, ENSP00000504735, ENSP00000502945, ENSP00000503804, ENST00000678805, ENST00000489459, ENST00000677022

Pharos - Targets

P62937

ZINC - Predictions - Purchasable

PPIA_HUMAN

HMDB Protein

HMDBP10691

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.713	3
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.676	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.666	4
UniProt:Q72497 Q72497			0.623	7
UniProt:P46108-1 CRK			0.595	4
UniProt:Q99IB8-PRO_0000045602			0.59	2
UniProt:P35613 BSG	2	BSG [Golgi membrane] (R-HSA-204478) BSG [plasma membrane] (R-HSA-197673)	0.589	2
UniProt:P62841 RPS15	2	RPS15 [nucleoplasm] (R-HSA-6798706) RPS15 [cytosol] (R-HSA-72335)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064)	0.556	3
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.556	3
UniProt:O43614 HCRTR2	1	HCRTR2 [plasma membrane] (R-HSA-389421)	0.556	3
UniProt:O00429 DNM1L	2	DNM1L [mitochondrial outer membrane] (R-HSA-351942) DNM1L [cytosol] (R-HSA-351943)	0.527	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:Q16849 PTPRN			0.508	3
UniProt:P0C6X7-PRO_0000037309 REP			0.508	4
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:O95831 AIFM1			0.463	2

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