Reactome | HUWE1 [ficolin-1-rich granule lumen]

HUWE1 [ficolin-1-rich granule lumen]

Stable Identifier

R-HSA-6801467

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule lumen

Synonyms

E3 ubiquitin-protein ligase HUWE1, HUWE1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q7Z6Z7 HUWE1

Gene Names

HUWE1, KIAA0312, KIAA1578, UREB1, HSPC272

Chain

chain:1-4374

Reference Genes

BioGPS Gene:10075 HUWE1

COSMIC (genes):HUWE1 HUWE1

CTD Gene:10075 HUWE1

dbSNP Gene:10075 HUWE1

ENSEMBL:ENSG00000086758 HUWE1

HGNC:30892 HUWE1

KEGG:hsa:10075 HUWE1

Monarch:10075 HUWE1

NCBI Gene:10075 HUWE1

OMIM:300697 HUWE1

UCSC:Q7Z6Z7 HUWE1

Reference Transcript

Participates

as a member of

Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)

Other forms of this molecule

HUWE1 [cytosol]

HUWE1 [secretory granule lumen]

HUWE1 [extracellular region]

Inferred To

HUWE1 [ficolin-1-rich granule lumen] (Bos taurus)

HUWE1 [ficolin-1-rich granule lumen] (Canis familiaris)

HUWE1 [ficolin-1-rich granule lumen] (Dictyostelium discoideum)

HUWE1 [ficolin-1-rich granule lumen] (Drosophila melanogaster)

HUWE1 [ficolin-1-rich granule lumen] (Plasmodium falciparum)

HUWE1 [ficolin-1-rich granule lumen] (Sus scrofa)

eel-1 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

ptr1 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

Huwe1 [ficolin-1-rich granule lumen] (Mus musculus)

Huwe1 [ficolin-1-rich granule lumen] (Rattus norvegicus)

TOM1 [ficolin-1-rich granule lumen] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_113584.3, XP_054182281.1, XP_005262022.1, XP_047297688.1, XP_054182282.1, XP_047297689.1, XP_047297687.1, XP_054182284.1, XP_054182283.1

OpenTargets

ENSG00000086758

ENSEMBL

ENSP00000340648, ENST00000612484, ENSP00000479451, ENST00000262854, ENSG00000086758, ENST00000342160, ENSP00000262854

IntEnz

2.3.2.26

HPA

ENSG00000086758-HUWE1

GeneCards

HUWE1

PRO

Q7Z6Z7

Pharos - Targets

Q7Z6Z7

Orphanet

HUWE1

GlyGen

Q7Z6Z7

HMDB Protein

HMDBP09257

PDB

7JQ9, 3G1N, 2MUL, 2EKK, 3H1D, 6PFL, 7MOP, 6FYH, 7MWD, 7AZX, 6MIW, 5LP8, 7MWE, 8RD0, 8RD7, 8RD1, 7MWF, 5C6H, 8R7O

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.878	12
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.677	5
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.527	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	3
UniProt:P20393 NR1D1	1	NR1D1 [nucleoplasm] (R-HSA-375499)	0.499	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	9

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