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HSPA1A [ficolin-1-rich granule lumen]
Stable Identifier
R-HSA-6801496
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule lumen
Synonyms
HSP70-1, Heat shock 70 kDa protein 1A, Heat shock 70 kDa protein 1, HSP70
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
HSPA1A [ficolin-1-rich granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P0DMV8 HSPA1A
Gene Names
HSPA1A, HSPA1, HSX70, HSP72
Chain
initiator methionine:1, chain:2-641
Reference Genes
BioGPS Gene:3303 HSPA1A
BioGPS Gene:3304 HSPA1A
COSMIC (genes):HSPA1A HSPA1A
CTD Gene:3303 HSPA1A
CTD Gene:3304 HSPA1A
dbSNP Gene:3303 HSPA1A
dbSNP Gene:3304 HSPA1A
ENSEMBL:ENSG00000204389 HSPA1A
ENSEMBL:ENSG00000204389.10 HSPA1A
ENSEMBL:ENSG00000215328 HSPA1A
ENSEMBL:ENSG00000215328.6 HSPA1A
ENSEMBL:ENSG00000234475 HSPA1A
ENSEMBL:ENSG00000234475.5 HSPA1A
ENSEMBL:ENSG00000235941 HSPA1A
ENSEMBL:ENSG00000235941.5 HSPA1A
ENSEMBL:ENSG00000237724 HSPA1A
ENSEMBL:ENSG00000237724.5 HSPA1A
HGNC:5232 HSPA1A
KEGG Gene (Homo sapiens):3303 HSPA1A
KEGG Gene (Homo sapiens):3304 HSPA1A
Monarch:3303 HSPA1A
Monarch:3304 HSPA1A
NCBI Gene:3303 HSPA1A
NCBI Gene:3304 HSPA1A
OMIM:140550 HSPA1A
OMIM:603012 HSPA1A
Reference Transcript
RefSeq:NM_005346.4 HSPA1A
RefSeq:NM_005345.5 HSPA1A
Other Identifiers
0006290288
1104_s_at
11744413_x_at
11757907_x_at
17006863
17006881
17026318
17026331
17027994
17028007
17030820
17030833
17038297
17038309
200799_PM_at
200799_at
200800_PM_s_at
200800_s_at
2902708
2902709
2902710
2902711
2902712
2902713
2902714
2902715
2902716
2902728
2902729
31692_at
3303
8118310
8118314
8178086
8179322
8179324
A_14_P121486
A_14_P200184
A_23_P111132
A_24_P123616
A_24_P682285
GE81493
GO:0000122
GO:0000166
GO:0000278
GO:0001618
GO:0001664
GO:0002376
GO:0003714
GO:0003723
GO:0005102
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005783
GO:0005813
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006402
GO:0006457
GO:0006986
GO:0007005
GO:0007010
GO:0007041
GO:0008180
GO:0008285
GO:0010628
GO:0012501
GO:0016071
GO:0016192
GO:0016234
GO:0016235
GO:0016607
GO:0016787
GO:0016887
GO:0019899
GO:0023052
GO:0030154
GO:0030163
GO:0030308
GO:0030512
GO:0031072
GO:0031249
GO:0031396
GO:0031397
GO:0031410
GO:0031625
GO:0031982
GO:0032436
GO:0032757
GO:0032991
GO:0033120
GO:0034599
GO:0034605
GO:0034620
GO:0036211
GO:0042026
GO:0042826
GO:0043066
GO:0043226
GO:0044183
GO:0045296
GO:0045648
GO:0046034
GO:0046718
GO:0047485
GO:0048471
GO:0048856
GO:0050821
GO:0051082
GO:0051085
GO:0051092
GO:0051131
GO:0051787
GO:0055131
GO:0060548
GO:0061024
GO:0065003
GO:0070062
GO:0070370
GO:0070434
GO:0071383
GO:0072562
GO:0090063
GO:0090084
GO:0097718
GO:0098772
GO:0140014
GO:0140416
GO:0140545
GO:0140657
GO:0140662
GO:1901029
GO:1901673
GO:1902236
GO:1902380
GO:1903265
GO:1904813
GO:1990904
GO:2001240
HMNXSV003042623
ILMN_1789074
M11717_rna1_at
PH_hs_0028967
PH_hs_0031321
TC06000384.hg
TC06000385.hg
TC6_apd_hap1000039.hg
TC6_cox_hap2000078.hg
TC6_dbb_hap3000069.hg
TC6_qbl_hap6000069.hg
g5579469_3p_at
Participates
as a member of
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
Other forms of this molecule
HSPA1A [cytosol]
HSPA1A [nucleoplasm]
HSPA1A [extracellular region]
Inferred To
HSPA1A [ficolin-1-rich granule lumen]
(Bos taurus)
HSPA1A [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
HSPA1A [ficolin-1-rich granule lumen]
(Canis familiaris)
HSPA1A [ficolin-1-rich granule lumen]
(Danio rerio)
HSPA1A [ficolin-1-rich granule lumen]
(Mus musculus)
HSPA1A [ficolin-1-rich granule lumen]
(Plasmodium falciparum)
HSPA1A [ficolin-1-rich granule lumen]
(Rattus norvegicus)
HSPA1A [ficolin-1-rich granule lumen]
(Sus scrofa)
HSPA1A [ficolin-1-rich granule lumen]
(Xenopus tropicalis)
Hsp70Ab [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Hsp70Bbb [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Hsp70Bb [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
DKEY-49H9.7 [ficolin-1-rich granule lumen]
(Danio rerio)
Homologues of HSPA1A [ficolin-1-rich granule lumen]
(Danio rerio)
Homologues of HSPA1A [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Homologues of HSPA1A [ficolin-1-rich granule lumen]
(Mus musculus)
Homologues of HSPA1A [ficolin-1-rich granule lumen]
(Plasmodium falciparum)
Homologues of HSPA1A [ficolin-1-rich granule lumen]
(Rattus norvegicus)
Homologues of HSPA1A [ficolin-1-rich granule lumen]
(Sus scrofa)
Hsp68 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Hsp70Aa [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Hsc70-2 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
si:ch211-199o1.2 [ficolin-1-rich granule lumen]
(Danio rerio)
Hsp70Bc [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
hsp70 [ficolin-1-rich granule lumen]
(Danio rerio)
Hsp70Ba [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Cross References
RefSeq
NP_005336.3
,
NP_005337.2
Guide to Pharmacology - Targets
2539
OpenTargets
ENSG00000204389
HPA
ENSG00000204389-HSPA1A
GeneCards
P0DMV8
Ensembl
ENST00000375651
,
ENSG00000235941
,
ENSG00000215328
,
ENSG00000237724
,
ENST00000433487
,
ENST00000400040
,
ENSG00000234475
,
ENSP00000364802
,
ENSP00000404524
,
ENSP00000406359
,
ENSP00000382915
,
ENST00000430065
,
ENST00000441618
,
ENSP00000408907
,
ENSG00000204389
PRO
P0DMV8
Pharos - Targets
P0DMV8
Orphanet
24606
HMDB Protein
HMDBP14535
PDB
1XQS
,
5GJJ
,
3A8Y
,
5BN9
,
2E8A
,
4IO8
,
5MKS
,
4WV7
,
4WV5
,
5BPN
,
5XI9
,
5BN8
,
3AY9
,
2E88
,
3ATV
,
5BPM
,
5AQZ
,
3ATU
,
6FHK
,
2LMG
,
7Q4R
,
5AQY
,
3Q49
,
3LOF
,
6G3R
,
5AR0
,
5BPL
,
5AQX
,
1S3X
,
6K39
,
5AQW
,
6ZYI
,
3D2F
,
5XIR
,
6G3S
,
4J8F
,
4PO2
,
3D2E
,
1HJO
,
5MKR
,
3JXU
,
6JPV
,
7KW7
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260-5 PRKN
0.556
6
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:P43405-2 P434052
0.556
3
UniProt:P54253 ATX1
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.556
3
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.556
3
UniProt:O75832 PSMD10
2
PSMD10 [nucleoplasm]
(R-HSA-174322)
PSMD10 [cytosol]
(R-HSA-68788)
0.544
2
UniProt:P0DTD2 9b
3
p-S53-9b [cytosol]
(R-COV-9758478)
9b [cytosol]
(R-COV-9694649)
9b [mitochondrial outer membrane]
(R-COV-9709803)
0.527
2
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.508
2
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