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PLK2 [cytosol]
Stable Identifier
R-HSA-6801636
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein kinase PLK2, Polo-like kinase 2, Serine/threonine-protein kinase SNK, SNK
Locations in the PathwayBrowser for interactor UniProt:Q8NEX9 SDR9C7
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by NPAS4 (Homo sapiens)
NPAS4 regulates expression of target genes (Homo sapiens)
NPAS4 stimulates PLK2 gene expression (Homo sapiens)
PLK2 [cytosol] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
PLK2 phosphorylates CENPJ (Homo sapiens)
PLK2 [cytosol] (Homo sapiens)
PLK2 phosphorylates NPM1 (Homo sapiens)
PLK2 [cytosol] (Homo sapiens)
TP53 stimulates PLK2 expression (Homo sapiens)
PLK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYY3 PLK2
Gene Names
PLK2, SNK
Chain
chain:1-685
Reference Genes
BioGPS Gene:10769 PLK2
COSMIC (genes):PLK2 PLK2
CTD Gene:10769 PLK2
dbSNP Gene:10769 PLK2
ENSEMBL:ENSG00000145632 PLK2
ENSEMBL_homo_sapiens_GENE:ENSG00000145632.15 PLK2
HGNC:19699 PLK2
KEGG Gene (Homo sapiens):10769 PLK2
Monarch:10769 PLK2
NCBI Gene:10769 PLK2
OMIM:607023 PLK2
UCSC:Q9NYY3 PLK2
Reference Transcript
RefSeq:NM_006622.3 PLK2
RefSeq:NM_001252226.1 PLK2
Other Identifiers
10769
11722162_a_at
11722163_x_at
11746837_a_at
11755161_s_at
16996433
201939_PM_at
201939_at
2858022
2858024
2858025
2858026
2858028
2858030
2858031
2858032
2858034
2858036
2858037
2858038
2858040
2858042
2858044
2858046
2858048
2858050
2858052
2858053
41544_at
8112202
A_23_P30254
GE54551
GO:0000082
GO:0000166
GO:0000278
GO:0000776
GO:0000785
GO:0000922
GO:0002376
GO:0002862
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005694
GO:0005737
GO:0005813
GO:0005814
GO:0005815
GO:0005829
GO:0005856
GO:0006468
GO:0006914
GO:0006954
GO:0006977
GO:0007010
GO:0007052
GO:0007265
GO:0007613
GO:0010508
GO:0012501
GO:0016301
GO:0016310
GO:0016525
GO:0016740
GO:0018105
GO:0023052
GO:0030163
GO:0030425
GO:0032486
GO:0036211
GO:0042995
GO:0043008
GO:0043066
GO:0043123
GO:0043226
GO:0045732
GO:0046599
GO:0048167
GO:0048856
GO:0048870
GO:0050877
GO:0060291
GO:0060292
GO:0071866
GO:0090050
GO:0106310
GO:0140096
GO:2000773
HMNXSV003048616
ILMN_1717706
PH_hs_0024593
TC05001385.hg
g5730054_3p_at
Participates
as a member of
PLK2, MAPK14 [cytosol] (Homo sapiens)
as an output of
NPAS4 stimulates PLK2 gene expression (Homo sapiens)
TP53 stimulates PLK2 expression (Homo sapiens)
Inferred To
PLK2 [cytosol]
(Bos taurus)
PLK2 [cytosol]
(Canis familiaris)
PLK2 [cytosol]
(Danio rerio)
PLK2 [cytosol]
(Gallus gallus)
PLK2 [cytosol]
(Mus musculus)
PLK2 [cytosol]
(Rattus norvegicus)
PLK2 [cytosol]
(Sus scrofa)
PLK2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001239155.1
,
NP_006613.2
ZINC - World Drugs
PLK2_HUMAN
Guide to Pharmacology - Targets
2169
OpenTargets
ENSG00000145632
ZINC - FDA approved
PLK2_HUMAN
ZINC - Substances
PLK2_HUMAN
ZINC - Biogenic
PLK2_HUMAN
ZINC target
Q9NYY3
PRO
Q9NYY3
PDB
4XB0
,
4I5P
,
4I6F
,
4RS6
,
4I6H
,
4I5M
,
4I6B
ZINC - Investigational
PLK2_HUMAN
HPA
ENSG00000145632-PLK2
GeneCards
Q9NYY3
Ensembl
ENST00000274289
,
ENSG00000145632
,
ENSP00000274289
Pharos - Targets
Q9NYY3
ZINC - Predictions - Purchasable
PLK2_HUMAN
HMDB Protein
HMDBP01434
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86Y33 CD20B
0.556
3
UniProt:Q8IW75 SPA12
0.527
2
UniProt:Q9H1E1 RNASE7
1
RNASE7 [extracellular region]
(R-HSA-6803118)
0.527
2
UniProt:O60911 CTSV
4
CTSL2 [lysosomal lumen]
(R-HSA-1181232)
CTSL2 [early endosome lumen]
(R-HSA-4127471)
CTSL2 [extracellular region]
(R-HSA-2228669)
CTSL2 [endolysosome lumen]
(R-HSA-4127477)
0.527
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.527
2
UniProt:Q8IWZ8 SUGP1
1
SUGP1 [nucleoplasm]
(R-HSA-72043)
0.527
2
UniProt:Q8NEX9 SDR9C7
1
SDR9C7 [endoplasmic reticulum membrane]
(R-HSA-4084690)
0.527
2
UniProt:O75635 SPB7
0.527
2
UniProt:Q9UI42 CBPA4
0.527
2
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