PLK2 phosphorylates NPM1

Stable Identifier
R-HSA-6801675
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PLK2 phosphorylates NPM1
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PLK2 phosphorylates NPM1 (nucleophosmin) on serine residue S4, which may be necessary to trigger centrosome duplication (Krause and Hoffmann 2010).
Literature References
PubMed ID Title Journal Year
20352051 Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication

Hoffmann, I, Krause, A

PLoS ONE 2010
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of PLK2 [cytosol]

Physical Entity
PLK2 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PLK2 phosphorylates NPM1 (Bos taurus)
PLK2 phosphorylates NPM1 (Canis familiaris)
PLK2 phosphorylates NPM1 (Gallus gallus)
PLK2 phosphorylates NPM1 (Mus musculus)
PLK2 phosphorylates NPM1 (Rattus norvegicus)
PLK2 phosphorylates NPM1 (Sus scrofa)
PLK2 phosphorylates NPM1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-02)
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