Reactome | PLK2 phosphorylates NPM1

PLK2 phosphorylates NPM1

Stable Identifier

R-HSA-6801675

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        PLK2 phosphorylates NPM1 (Homo sapiens)

General

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PLK2 phosphorylates NPM1 (nucleophosmin) on serine residue S4, which may be necessary to trigger centrosome duplication (Krause and Hoffmann 2010).

Literature References