Reactome | p-S4-NPM1 [cytosol]

p-S4-NPM1 [cytosol]

Stable Identifier

R-HSA-6801679

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser for interactor UniProt:Q01780 EXOSC10

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        PLK2 phosphorylates NPM1 (Homo sapiens)
        
        p-S4-NPM1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06748 NPM1

Gene Names

NPM1, NPM

Chain

chain:1-294

Reference Genes

COSMIC (genes):NPM1 NPM1

dbSNP Gene:4869 NPM1

ENSEMBL:ENSG00000181163 NPM1

Participates

as an output of

PLK2 phosphorylates NPM1 (Homo sapiens)

Other forms of this molecule

NPM1 [cytosol]

NPM1 [nucleoplasm]

NPM1 [granular component]

NPM1(1-117)-ALK(1058-1620) fusion [cytosol]

NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]

NPM1(1-117)-ALK(1068-1620) fusion [cytosol]

NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]

NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]

polySUMO2,3-K263-NPM1 [nucleoplasm]

monoSUMO1-K263-NPM1 [nucleoplasm]

Inferred To

phospho-p-S4-NPM1 [cytosol] (Bos taurus)

phospho-p-S4-NPM1 [cytosol] (Gallus gallus)

phospho-Nph [cytosol] (Drosophila melanogaster)

phospho-CG12644 [cytosol] (Drosophila melanogaster)

phospho-LOC511386 [cytosol] (Bos taurus)

phospho-NPM1 [cytosol] (Bos taurus)

phospho-NPM1 [cytosol] (Canis familiaris)

phospho-NPM1 [cytosol] (Sus scrofa)

phospho-Nlp [cytosol] (Drosophila melanogaster)

phospho-npm1 [cytosol] (Xenopus tropicalis)

Homologues of p-S4-NPM1 [cytosol] (Bos taurus)

Homologues of p-S4-NPM1 [cytosol] (Drosophila melanogaster)

phospho-Npm1 [cytosol] (Mus musculus)

phospho-Npm1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 4

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Interactors (209)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BK5 PINX1			0.81	13
UniProt:Q9H4L4 SENP3	1	SENP3 [nucleoplasm] (R-HSA-2984296)	0.78	7
UniProt:Q86SE8 NPM2	1	NPM2 [nucleoplasm] (R-HSA-9821980)	0.743	8
UniProt:O75607 NPM3			0.725	6
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.712	4
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.712	6
UniProt:Q14137 BOP1	1	BOP1 [nucleoplasm] (R-HSA-6791206)	0.706	4
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.706	4
UniProt:Q14684 RRP1B			0.706	5
UniProt:Q13823 NOG2			0.706	4
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.697	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.676	6
UniProt:Q71RC2 LARP4			0.669	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.664	4
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.65	3
UniProt:Q96CT7 CC124			0.649	8
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.643	3
UniProt:Q9BZE4 GTPB4			0.643	4
UniProt:P61313 RPL15	1	RPL15 [cytosol] (R-HSA-72416)	0.643	3
UniProt:Q15397 PUM3			0.643	4
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.643	3
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.64	3
UniProt:B1Q2W9 B1Q2W9			0.639	8
UniProt:P24938 CORE5			0.623	4
UniProt:Q6UPD4 Q6UPD4			0.619	4
UniProt:Q14692 BMS1	1	BMS1 [nucleoplasm] (R-HSA-6790720)	0.615	3
UniProt:Q9ULW3 ABT1			0.615	3
UniProt:P05386 RPLP1	1	RPLP1 [cytosol] (R-HSA-72398)	0.615	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.615	3
UniProt:Q9GZL7 WDR12	1	WDR12 [nucleoplasm] (R-HSA-6791215)	0.615	3
UniProt:P42696 RBM34			0.615	4
UniProt:O15226 NKRF			0.615	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	15
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.615	3
UniProt:Q9H6F5 CCD86			0.615	3
UniProt:Q9Y3C1 NOP16			0.615	4
UniProt:Q15050 RRS1			0.615	4
UniProt:O00566 MPHOSPH10	1	MPHOSPH10 [nucleoplasm] (R-HSA-6790661)	0.615	3
UniProt:O15381 NVL			0.615	3
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.615	3
UniProt:Q12788 TBL3	1	TBL3 [nucleoplasm] (R-HSA-6790620)	0.615	3
UniProt:Q9Y3B9 RRP15			0.615	3
UniProt:Q6PK04 CC137			0.615	3
UniProt:Q96GQ7 DDX27			0.615	4
UniProt:Q9BYG3 MK67I			0.615	3
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.615	4
UniProt:Q9BQ39 DDX50			0.615	3
UniProt:Q01780 EXOSC10	1	EXOSC10 [nucleoplasm] (R-HSA-6791547)	0.615	3
UniProt:Q9NRX1 PNO1	2	PNO1 [nucleoplasm] (R-HSA-6791540) PNO1 [cytosol] (R-HSA-6791509)	0.615	3
UniProt:P19525 EIF2AK2	5	EIF2AK2 [cytosol] (R-HSA-168699) p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) p-EIF2AK2 [cytosol] (R-HSA-9833834) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829)	0.602	4
UniProt:Q9BZQ8 NIBA1			0.602	7
UniProt:Q9BXL5 HEMGN			0.599	7
UniProt:P49450 CENPA	2	CENPA [nucleoplasm] (R-HSA-606322) CENPA [cytosol] (R-HSA-375317)	0.597	4
UniProt:P68951 NP			0.591	5
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.591	6
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.59	2
UniProt:P0DOE7 M	5	p-S95,T205-M [cytosol] (R-RSY-9831678) p-S95,T205-M [nucleoplasm] (R-RSY-9831706) M [nucleoplasm] (R-RSY-9831711) Nascent M [cytosol] (R-RSY-9828672) p-S95,T205-M [viral tegument] (R-RSY-9836531)	0.576	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.576	5
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.571	2
UniProt:Q9NX58 LYAR			0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.564	2
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.564	2
UniProt:P49207 RPL34	1	RPL34 [cytosol] (R-HSA-72458)	0.564	2
UniProt:Q92876 KLK6			0.556	3
UniProt:P10176 COX8A	1	COX8A [mitochondrial inner membrane] (R-HSA-164313)	0.556	3
UniProt:Q86SE8-2 NPM2			0.556	5
UniProt:P03427 PB2			0.547	3
UniProt:Q8N3Z6 ZCHC7			0.536	2
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.536	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.532	3
UniProt:O76021 RL1D1			0.527	2
UniProt:Q92522 H1X			0.527	2
UniProt:Q6PGP7 SKIC3	1	TTC37 [cytosol] (R-HSA-8931541)	0.527	2
UniProt:P62263 RPS14	2	RPS14 [cytosol] (R-HSA-72333) RPS14 [nucleoplasm] (R-HSA-6790669)	0.527	2
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:Q9HCM4 EPB41L5	1	EPB41L5 [cytosol] (R-HSA-6797564)	0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	3
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.527	2
UniProt:P63220 RPS21	2	RPS21 [cytosol] (R-HSA-72351) RPS21 [nucleoplasm] (R-HSA-6798732)	0.527	2
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:P60866 RPS20	2	RPS20 [cytosol] (R-HSA-72349) RPS20 [nucleoplasm] (R-HSA-6798727)	0.527	2
UniProt:Q5JTH9 RRP12			0.527	2
UniProt:Q6P158 DHX57			0.527	2
UniProt:Q49A26 GLYR1			0.527	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.527	2
UniProt:Q71UM5 RPS27L	2	RPS27L [nucleoplasm] (R-HSA-6791197) RPS27L [cytosol] (R-HSA-8868849)	0.527	2
UniProt:Q14694 USP10	3	USP10 [cytosol] (R-HSA-6782974) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [nucleoplasm] (R-HSA-3222218)	0.527	2
UniProt:P62861 FAU	2	FAU [cytosol] (R-HSA-72371) FAU [nucleoplasm] (R-HSA-6798717)	0.527	2
UniProt:Q969S3 ZN622			0.527	2
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	3
UniProt:Q9GZR2 REXO4			0.527	3
UniProt:P46013 KI67			0.527	2
UniProt:O75818 RPP40	1	RPP40 [nucleoplasm] (R-HSA-5696801)	0.527	3
UniProt:P35251 RFC1	1	RFC1 [nucleoplasm] (R-HSA-68435)	0.527	2
UniProt:Q9P287 BCCIP			0.527	2
UniProt:P62857 RPS28	2	RPS28 [cytosol] (R-HSA-72365) RPS28 [nucleoplasm] (R-HSA-6791202)	0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:Q99613 EIF3C	1	EIF3C [cytosol] (R-HSA-72550)	0.527	2
UniProt:Q9NXF1 TEX10	1	TEX10 [nucleoplasm] (R-HSA-3826589)	0.527	3
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.527	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.527	2
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:Q7Z478 DHX29			0.527	2
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.527	2
UniProt:Q06787 FMR1			0.527	3
UniProt:O75683 SURF6			0.527	3
UniProt:P62750 RPL23A	1	RPL23A [cytosol] (R-HSA-72432)	0.527	3
UniProt:O76094 SRP72	1	SRP72 [cytosol] (R-HSA-265069)	0.527	2
UniProt:Q8TDN6 BRX1			0.527	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:Q14152 EIF3A	1	EIF3A [cytosol] (R-HSA-72546)	0.527	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	2
UniProt:O95707 POP4	1	POP4 [nucleoplasm] (R-HSA-5696789)	0.527	3
UniProt:Q15477 SKIC2	1	SKIV2L [cytosol] (R-HSA-391294)	0.527	2
UniProt:Q9UNX4 WDR3	1	WDR3 [nucleoplasm] (R-HSA-6790724)	0.527	2
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.527	2
UniProt:Q96HI0 SENP5	1	SENP5 [nucleoplasm] (R-HSA-2984297)	0.527	3
UniProt:Q8TDD1 DDX54			0.527	3
UniProt:P46783 RPS10	2	RPS10 [cytosol] (R-HSA-72325) RPS10 [nucleoplasm] (R-HSA-6798733)	0.527	2
UniProt:P46782 RPS5	2	RPS5 [cytosol] (R-HSA-72379) RPS5 [nucleoplasm] (R-HSA-6791188)	0.527	2
UniProt:Q9H7B2 RPF2			0.527	2
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:Q99575 POP1	1	POP1 [nucleoplasm] (R-HSA-5696802)	0.527	2
UniProt:P78346 RPP30	1	RPP30 [nucleoplasm] (R-HSA-5696779)	0.527	2
UniProt:Q7KZF4 SND1	2	SND1(1-593)-BRAF(381-766) fusion [cytosol] (R-HSA-6802469) SND1(1-593)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802552)	0.527	2
UniProt:Q6NW34 NEPRO			0.527	3
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.527	2
UniProt:Q6DKI1 RL7L			0.527	3
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:Q9Y4W2 LAS1L	1	LAS1L [nucleoplasm] (R-HSA-6791521)	0.527	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.524	2
UniProt:Q98147 Q98147			0.524	2
UniProt:Q14684-1 RRP1B			0.512	4
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.499	2
UniProt:Q9UQ80 PA2G4	2	PA2G4 [extracellular region] (R-HSA-6806200) PA2G4 [azurophil granule lumen] (R-HSA-6799205)	0.491	3
UniProt:O14965 AURKA	6	p-T288-AURKA [cytosol] (R-HSA-2574832) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)	0.489	3
UniProt:Q8N8A6 DDX51			0.483	2
UniProt:Q8NHQ9 DDX55			0.483	3
UniProt:Q9BXY0 MAK16			0.483	3
UniProt:Q68D10 SPT2			0.483	2
UniProt:Q8N9T8 KRI1			0.483	2
UniProt:P48634 PRC2A			0.483	2
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.483	2
UniProt:Q08J23 NSUN2	1	NSUN2 [nucleoplasm] (R-HSA-6782382)	0.483	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.483	2
UniProt:Q9BRJ6 CG050			0.483	2
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.483	2
UniProt:O95793 STAU1			0.483	2
UniProt:Q9H501 ESF1			0.483	2
UniProt:Q6MZP7 LIN54	1	LIN54 [nucleoplasm] (R-HSA-389103)	0.483	2
UniProt:Q8NEJ9 NGDN			0.483	2
UniProt:Q9NZM5 NOP53			0.483	3
UniProt:Q9NVU7 SDA1			0.483	2
UniProt:P35250 RFC2	1	RFC2 [nucleoplasm] (R-HSA-68433)	0.483	2
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.483	2
UniProt:Q9H6Y2 WDR55			0.483	2
UniProt:Q9BSC4 NOL10			0.483	2
UniProt:Q5QJE6 TDIF2			0.483	2
UniProt:Q9ULJ3 ZBT21			0.483	2
UniProt:Q96B26 EXOSC8	2	EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.483	2
UniProt:Q8IY37 DHX37	1	DHX37 [nucleoplasm] (R-HSA-6790668)	0.483	2
UniProt:Q14781 CBX2	1	CBX2 [nucleoplasm] (R-HSA-389110)	0.483	2
UniProt:Q2TB10 ZN800			0.483	3
UniProt:Q96L73 NSD1	1	NSD1 [nucleoplasm] (R-HSA-1183232)	0.483	2
UniProt:Q13206 DDX10			0.483	2
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.483	2
UniProt:Q9H9L3 ISG20L2	1	ISG20L2 [nucleoplasm] (R-HSA-6799476)	0.483	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.483	2
UniProt:O95625 ZBT11			0.483	2
UniProt:Q9BRD0 BUD13	1	BUD13 [nucleoplasm] (R-HSA-9769522)	0.483	3
UniProt:Q86U86 PBRM1	1	PBRM1 [nucleoplasm] (R-HSA-389254)	0.483	2
UniProt:Q8WYP5 AHCTF1	1	AHCTF1 [cytosol] (R-HSA-376244)	0.483	2
UniProt:Q03188 CENPC	2	CENPC [nucleoplasm] (R-HSA-5633512) CENPC1 [cytosol] (R-HSA-375292)	0.483	2
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.483	2
UniProt:Q9Y2R4 DDX52	1	DDX52 [nucleoplasm] (R-HSA-6790703)	0.483	2
UniProt:Q9Y4C8 RBM19			0.483	2
UniProt:Q86VM9 ZCH18			0.483	3
UniProt:Q14966 ZNF638	1	ZNF638 [nucleoplasm] (R-HSA-8939429)	0.483	2
UniProt:Q12789 GTF3C1	1	GTF3C1 [nucleoplasm] (R-HSA-83697)	0.483	2
UniProt:Q9BVJ6 UTP14A	1	UTP14A [nucleoplasm] (R-HSA-6790695)	0.483	2
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.483	2
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.483	2
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.483	2
UniProt:Q9NUL3 STAU2			0.483	2
UniProt:Q03701 CEBPZ			0.483	2
UniProt:Q9NQT5 EXOSC3	2	EXOSC3 [nucleoplasm] (R-HSA-6791572) EXOSC3 [cytosol] (R-HSA-430017)	0.483	2
UniProt:Q8NDF8 PAPD5			0.483	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.483	2
UniProt:Q8NFW8 CMAS	1	CMAS [nucleoplasm] (R-HSA-4085417)	0.483	2
UniProt:P78344 EIF4G2	1	EIF4G2 [cytosol] (R-HSA-1678826)	0.483	2
UniProt:P78345 RPP38	1	RPP38 [nucleoplasm] (R-HSA-5696791)	0.483	3
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.483	2
UniProt:Q9UIG0 BAZ1B	1	BAZ1B [nucleoplasm] (R-HSA-417153)	0.483	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.483	2
UniProt:Q02880 TOP2B	2	monoSUMO1-K-TOP2B [nucleoplasm] (R-HSA-4641297) TOP2B [nucleoplasm] (R-HSA-4641359)	0.483	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.483	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.483	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:P11388 TOP2A	3	TOP2A [nucleoplasm] (R-HSA-1362276) polySUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) monoSUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.483	2
UniProt:Q8IUH3 RBM45			0.462	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	3