AP3B1(1-859)-BRAF(381-766) fusion [cytosol]

Stable Identifier
R-HSA-6802269
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
25204415 The landscape of kinase fusions in cancer

Kim, JL, Schalm, S, Stransky, N, Lengauer, C, Cerami, E

Nat Commun 2014
External Reference Information
External Reference
UniProt:O00203 AP3B1
Gene Names
AP3B1, ADTB3A
Chain
chain:1-1094
Reference Genes
COSMIC (genes):AP3B1 AP3B1
dbSNP Gene:8546 AP3B1
ENSEMBL:ENSG00000132842 AP3B1
Participates
as a component of
Other forms of this molecule
AP3B1 [Golgi membrane]
AP3B1 [cytoplasmic vesicle membrane]
AP3B1(1-859)-p-BRAF(381-766) fusion [cytosol]
Modified Residues
Name
Insertion of residues 381 to 766 at 860 from UniProt:P15056 BRAF
Coordinate
860
Name
O-phospho-L-serine at 446
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
thyroid carcinoma DOID:3963 head and neck cancer, Thyroid
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Interactors (6)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q5S007 LRRK2  1 0.564 2
 UniProt:P42858 HTT  1 0.556 6
 UniProt:Q96CV9 OPTN  6 0.556 3
 UniProt:P37840 SNCA  5 0.556 3
 UniProt:P0DTC4 E  9 0.527 2
 UniProt:Q96BA8 CREB3L1  7 0.527 2
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