Reactome | BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]

BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]

Stable Identifier

R-HSA-6802276

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
25204415	The landscape of kinase fusions in cancer Kim, JL, Schalm, S, Stransky, N, Lengauer, C, Cerami, E	Nat Commun	2014

External Reference Information

External Reference

UniProt:O43521 BCL2L11

Gene Names

BCL2L11, BIM

Chain

chain:1-198

Reference Genes

COSMIC (genes):BCL2L11 BCL2L11

dbSNP Gene:10018 BCL2L11

ENSEMBL:ENSG00000153094 BCL2L11

Participates

as a component of

BCL2L11-BRAF fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

BCL2L11 [mitochondrial outer membrane]

p-S69-BCL2L11 [cytosol]

BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]

p-BCL2L11 [mitochondrial outer membrane]

p-BCL2L11 [cytosol]

BCL2L11 [cytosol]

Modified Residues

Name

Insertion of residues 397 to 766 at 132 from UniProt:P15056 BRAF

Coordinate

132

Name

O-phospho-L-serine at 446

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
thyroid carcinoma	DOID:3963	head and neck cancer, Thyroid
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.948	19
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.943	22
UniProt:Q07817-1 BCL2L1			0.935	10
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.926	11
UniProt:Q92843 B2CL2			0.901	10
UniProt:Q9HD36 B2L10			0.832	11
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.826	11
UniProt:P97287 MCL1			0.796	7
UniProt:Q16548 BCL2A1	1	BCL2A1 [cytosol] (R-HSA-9725307)	0.683	4
UniProt:P68451 PG045			0.621	4
UniProt:Q07440 B2LA1			0.609	2
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.589	2
UniProt:Q07813-1 BAX			0.558	7
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:P03495 NS1			0.508	2
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.499	2

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