Reactome | FXR1(2-784)-BRAF(381-766) fusion [cytosol]

FXR1(2-784)-BRAF(381-766) fusion [cytosol]

Stable Identifier

R-HSA-6802326

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
23583981	Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas Zhang, J, Wu, G, Miller, CP, Tatevossian, RG, Dalton, JD, Tang, B, Orisme, W, Punchihewa, C, Parker, M, Qaddoumi, I, Boop, FA, Lu, C, Kandoth, C, Ding, L, Lee, R, Huether, R, Chen, X, Hedlund, E, Nagahawatte, P, Rusch, M, Boggs, K, Cheng, J, Becksfort, J, Ma, J, Song, G, Li, Y, Wei, L, Wang, J, Shurtleff, S, Easton, J, Zhao, D, Fulton, RS, Fulton, LL, Dooling, DJ, Vadodaria, B, Mulder, HL, Tang, C, Ochoa, K, Mullighan, CG, Gajjar, A, Kriwacki, R, Sheer, D, Gilbertson, RJ, Mardis, ER, Wilson, RK, Downing, JR, Baker, SJ, Ellison, DW	Nat. Genet.	2013

External Reference Information

External Reference

UniProt:P51114 FXR1

Gene Names

FXR1

Chain

initiator methionine:1, chain:2-621

Reference Genes

BioGPS Gene:8087 FXR1

COSMIC (genes):FXR1 FXR1

CTD Gene:8087 FXR1

dbSNP Gene:8087 FXR1

ENSEMBL:ENSG00000114416 FXR1

HGNC:4023 FXR1

KEGG:hsa:8087 FXR1

Monarch:8087 FXR1

NCBI Gene:8087 FXR1

OMIM:600819 FXR1

UCSC:P51114 FXR1

Reference Transcript

Participates

as a component of

FXR1-BRAF fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

FXR1(2-784)-p-BRAF(381-766) fusion [cytosol]

Modified Residues

Name

Insertion of residues 381 to 766 at 785 from UniProt:P15056 BRAF

Coordinate

785

Name

O-phospho-L-serine at 446

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
astrocytoma	DOID:3069	astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
pilocytic astrocytoma	DOID:4851	Piloid astrocytoma, grade I Astrocytic tumor

Cross References

RefSeq

NP_001013456.1, NP_001013457.1, NP_005078.2

ENSEMBL

ENST00000357559, ENST00000305586, ENST00000445140, ENSG00000114416, ENSP00000350170, ENSP00000307633, ENSP00000388828

OpenTargets

ENSG00000114416

Mondo

0021636

GeneCards

FXR1

HPA

ENSG00000114416-FXR1

PRO

P51114

Pharos - Targets

P51114

GlyGen

P51114

PDB

2CPQ, 3O8V, 3KUF

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.553	2
UniProt:P23246 SFPQ	3	SFPQ [nucleoplasm] (R-HSA-3900138) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [cytosol] (R-HSA-9635505)	0.547	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.528	3
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	2
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.508	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.508	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.508	2
UniProt:Q674X7 KAZN	1	KAZN [cytosol] (R-HSA-6814378)	0.508	2
UniProt:P21333 FLNA	3	FLNA [cytosol] (R-HSA-210019) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [extracellular region] (R-HSA-350712)	0.508	2
UniProt:Q86UR5 RIMS1	1	RIMS1 [cytosol] (R-HSA-210407)	0.499	2

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