TRIM24(1-510)-BRAF(381-766) fusion [cytosol]

Stable Identifier
R-HSA-6802477
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
24345920 BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition

Hutchinson, KE, Lipson, D, Stephens, PJ, Otto, G, Lehmann, BD, Lyle, PL, Vnencak-Jones, CL, Ross, JS, Pietenpol, JA, Sosman, JA, Puzanov, I, Miller, VA, Pao, W

Clin. Cancer Res. 2013
External Reference Information
External Reference
UniProt:O15164 TRIM24
Gene Names
TRIM24, RNF82, TIF1, TIF1A
Chain
chain:1-1050
Reference Genes
BioGPS Gene:8805 TRIM24
COSMIC (genes):TRIM24 TRIM24
CTD Gene:8805 TRIM24
dbSNP Gene:8805 TRIM24
ENSEMBL:ENSG00000122779 TRIM24
HGNC:11812 TRIM24
KEGG:hsa:8805 TRIM24
Monarch:8805 TRIM24
NCBI Gene:8805 TRIM24
OMIM:603406 TRIM24
UCSC:O15164 TRIM24
Reference Transcript
Other Identifiers
11729816_x_at
11749468_a_at
11758692_s_at
1569316_PM_at
1569316_at
17052115
204391_PM_x_at
204391_x_at
213301_PM_x_at
213301_x_at
3026603
3026604
3026605
3026606
3026607
3026608
3026609
3026622
3026626
3026628
3026633
3026634
3026636
3026637
3026642
3026643
3026644
3026645
3026647
3026648
3026649
3026650
3026651
3026653
3026654
3026656
3026657
3026658
3026660
3026661
3026662
3026663
3026664
3026665
3026666
3026667
3026668
3026670
3026672
39292_r_at
66615_at
8136473
83662_at
8805
A_14_P122921
A_14_P124392
A_14_P131860
A_14_P138691
A_23_P93629
A_33_P3259028
GE62625
GE863285
GO:0000785
GO:0000791
GO:0001673
GO:0002039
GO:0003677
GO:0003682
GO:0003713
GO:0003824
GO:0004672
GO:0004842
GO:0005102
GO:0005515
GO:0005634
GO:0005654
GO:0005726
GO:0005737
GO:0005739
GO:0005829
GO:0006325
GO:0006351
GO:0006355
GO:0006366
GO:0008270
GO:0010628
GO:0016567
GO:0016740
GO:0016922
GO:0030163
GO:0031647
GO:0031981
GO:0034056
GO:0042981
GO:0043434
GO:0043565
GO:0045892
GO:0045893
GO:0046872
GO:0050673
GO:0050680
GO:0055074
GO:0061630
GO:0070562
GO:0071391
GO:0140096
GO:0140118
GO:1901796
HMNXSV003048357
HMNXSV003050282
Hs2.125798.1.S1_3p_at
ILMN_1711247
ILMN_1799642
ILMN_2405031
PH_hs_0010837
TC07000868.hg
g7706233_3p_a_at
Participates
as a component of
Other forms of this molecule
TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol]
TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol]
TRIM24(1-626)-FGFR1(429-822) fusion [cytosol]
Modified Residues
Name
Insertion of residues 381 to 766 at 511 from UniProt:P15056 BRAF
Coordinate
511
Name
O-phospho-L-serine at 446
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
Mondo
ZINC - Substances
ZINC target
PRO
GlyGen
PDB
HPA
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (4)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9UPN9 TRIM33  1 0.794 6
 UniProt:P03372 ESR1  10 0.641 3
 UniProt:Q13263 TRIM28  3 0.597 3
 UniProt:P04637 TP53  20 0.524 3
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