Reactome | ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol]

ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol]

Stable Identifier

R-HSA-6802506

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
25204415	The landscape of kinase fusions in cancer Kim, JL, Schalm, S, Stransky, N, Lengauer, C, Cerami, E	Nat Commun	2014

External Reference Information

External Reference

UniProt:Q7Z2W4 ZC3HAV1

Gene Names

ZC3HAV1, ZC3HDC2, PRO1677

Chain

initiator methionine:, chain:2-902

Reference Genes

BioGPS Gene:56829 ZC3HAV1

COSMIC (genes):ZC3HAV1 ZC3HAV1

CTD Gene:56829 ZC3HAV1

dbSNP Gene:56829 ZC3HAV1

ENSEMBL:ENSG00000105939 ZC3HAV1

HGNC:23721 ZC3HAV1

KEGG:hsa:56829 ZC3HAV1

Monarch:56829 ZC3HAV1

NCBI Gene:56829 ZC3HAV1

OMIM:607312 ZC3HAV1

UCSC:Q7Z2W4 ZC3HAV1

Reference Transcript

Participates

as a component of

ZC3HAV1-BRAF fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol]

Modified Residues

Name

Insertion of residues 439 to 766 at 625 from UniProt:P15056 BRAF

Coordinate

625

Name

O-phospho-L-serine at 446

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
thyroid carcinoma	DOID:3963	head and neck cancer, Thyroid
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

ENSEMBL

ENST00000242351, ENSP00000242351, ENST00000471652, ENSG00000105939, ENSP00000419855

OpenTargets

ENSG00000105939

GeneCards

ZC3HAV1

HPA

ENSG00000105939-ZC3HAV1

PRO

Q7Z2W4

Pharos - Targets

Q7Z2W4

GlyGen

Q7Z2W4

PDB

6UEJ, 6UEI, 2X5Y, 7TGQ, 7KZH, 4X52

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.564	4
UniProt:Q9NQT4 EXOSC5	3	EXOSC5 [cytosol] (R-HSA-429889) EXOSC5 [nucleoplasm] (R-HSA-6791550) EXOSC5 [nucleolus] (R-HSA-9935829)	0.536	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q15646 OASL	1	OASL [cytosol] (R-HSA-1015678)	0.527	2
UniProt:O95786 RIGI	4	DDX58 [cytosol] (R-HSA-168917) K63polyUb-DDX58 [cytosol] (R-HSA-918191) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) PolyUb-DDX58 [cytosol] (R-HSA-6782770)	0.524	3
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	4
UniProt:Q8WYQ5 DGCR8	1	DGCR8 [nucleoplasm] (R-HSA-1482509)	0.483	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.483	2

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