PAPSS1(1-223)-p-BRAF(381-766) fusion [cytosol]

Stable Identifier
R-HSA-6802543
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
24345920 BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition

Hutchinson, KE, Lyle, PL, Puzanov, I, Sosman, JA, Pietenpol, JA, Lehmann, BD, Ross, JS, Lipson, D, Vnencak-Jones, CL, Stephens, PJ, Miller, VA, Otto, G, Pao, W

Clin. Cancer Res. 2013
External Reference Information
External Reference
UniProt:O43252 PAPSS1
Gene Names
PAPSS1, ATPSK1, PAPSS
Chain
chain:1-624
Reference Genes
BioGPS Gene:9061 PAPSS1
COSMIC (genes):PAPSS1 PAPSS1
CTD Gene:9061 PAPSS1
dbSNP Gene:9061 PAPSS1
ENSEMBL:ENSG00000138801 PAPSS1
ENSEMBL_homo_sapiens_GENE:ENSG00000138801.9 PAPSS1
HGNC:8603 PAPSS1
KEGG Gene (Homo sapiens):9061 PAPSS1
Monarch:9061 PAPSS1
NCBI Gene:9061 PAPSS1
OMIM:603262 PAPSS1
UCSC:O43252 PAPSS1
Reference Transcript
Other Identifiers
11727372_at
11727373_s_at
11751595_a_at
16978793
209043_PM_at
209043_at
2781002
2781003
2781004
2781005
2781019
2781020
2781022
2781026
2781027
2781028
2781029
2781030
2781031
2781032
2781033
2781034
2781035
2781041
2781042
34411_at
8102214
9061
A_23_P144465
GE54804
GO:0000103
GO:0000166
GO:0001501
GO:0003824
GO:0004020
GO:0004781
GO:0005524
GO:0005829
GO:0006790
GO:0008152
GO:0009152
GO:0016301
GO:0016310
GO:0016740
GO:0016779
GO:0034030
GO:0034033
GO:0042803
GO:0048856
GO:0050428
GO:0055086
GO:1901135
HMNXSV003000466
ILMN_1781819
ILMN_2224103
PH_hs_0027050
TC04001455.hg
g3378100_3p_at
Participates
as a component of
Other forms of this molecule
PAPSS1 [cytosol]
PAPSS1(1-223)-BRAF(381-766) fusion [cytosol]
Modified Residues
Name
Insertion of residues 381 to 766 at 224 from UniProt:P15056 BRAF
Coordinate
224
Name
O-phospho-L-serine at 446
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
HMDB Protein
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