Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS

Stable Identifier
R-HSA-6802922
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAPK proteins are phosphorylated downstream of oncogenic RAS mutants; somewhat surprisingly, however, steady state levels of phospho-MAP2K and phospho-MAPKs are not always elevated in cancer cells (reviewed in Ramos, 2008; Neuzillet et al, 2014; Stephen et al, 2014).

Literature References
PubMed ID Title Journal Year
24121058 MEK in cancer and cancer therapy

Neuzillet, C, Tijeras-Raballand, A, de Mestier, L, Cros, J, Faivre, S, Raymond, E

Pharmacol. Ther. 2014
18562239 The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

Ramos, JW

Int. J. Biochem. Cell Biol. 2008
24651010 Dragging ras back in the ring

Stephen, AG, Esposito, D, Bagni, RK, McCormick, F

Cancer Cell 2014
Participants
Participates
Catalyst Activity

protein serine/threonine/tyrosine kinase activity of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]

Normal reaction
Functional status

Gain of function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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