Mutant RAS:p-RAF complexes phosphorylate MAP2Ks

Stable Identifier
R-HSA-6802926
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Mutant RAS:p-RAF complexes phosphorylate MAP2Ks
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MAP2K proteins are phosphorylated downstream of oncogenic RAS mutants; somewhat surprisingly, however, steady state levels of phospho-MAP2K and phospho-MAPKs are not always elevated in cancer cells (reviewed in Ramos, 2008; Neuzillet et al, 2014; Stephen et al, 2014).

Literature References
PubMed ID Title Journal Year
18562239 The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

Ramos, JW

Int. J. Biochem. Cell Biol. 2008
24121058 MEK in cancer and cancer therapy

Tijeras-Raballand, A, Faivre, S, Neuzillet, C, Raymond, E, de Mestier, L, Cros, J

Pharmacol. Ther. 2014
24651010 Dragging ras back in the ring

McCormick, F, Stephen, AG, Bagni, RK, Esposito, D

Cancer Cell 2014
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane]

Physical Entity
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Normal reaction
RAF phosphorylates MAP2K dimer (Homo sapiens)
Functional status

Gain of function of mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2015-05-18)
Reviewed
Stephens, RM  (2016-08-05)
Created
Rothfels, K  (2015-10-02)
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