Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PNP [ficolin-1-rich granule lumen]
Stable Identifier
R-HSA-6803278
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule lumen
Synonyms
nucleoside phosphorylase, NP, Purine nucleoside phosphorylase (EC 2.4.2.1) (Inosine phosphorylase) (PNP), Inosine phosphorylase
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
PNP [ficolin-1-rich granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00491 PNP
Gene Names
PNP, NP
Chain
chain:1-289
Reference Genes
BioGPS Gene:4860 PNP
COSMIC (genes):PNP PNP
CTD Gene:4860 PNP
dbSNP Gene:4860 PNP
ENSEMBL:ENSG00000198805 PNP
ENSEMBL_homo_sapiens_GENE:ENSG00000198805.13 PNP
ENSEMBL_homo_sapiens_GENE:ENSG00000291814.1 PNP
HGNC:7892 PNP
KEGG Gene (Homo sapiens):4860 PNP
Monarch:4860 PNP
NCBI Gene:4860 PNP
OMIM:164050 PNP
Reference Transcript
RefSeq:NM_000270.3 PNP
Other Identifiers
11718400_a_at
16781536
201695_PM_s_at
201695_s_at
3527515
3527518
3527520
3527522
3527523
3527525
3527527
3527528
3527529
3527530
3527531
430_at
4860
7973067
A_23_P140256
GO:0000255
GO:0001882
GO:0002060
GO:0002376
GO:0003824
GO:0004731
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0006139
GO:0006148
GO:0006149
GO:0006157
GO:0006166
GO:0006204
GO:0006738
GO:0006955
GO:0007155
GO:0009116
GO:0009165
GO:0009410
GO:0016740
GO:0016757
GO:0016763
GO:0030154
GO:0031410
GO:0032743
GO:0034418
GO:0034774
GO:0042102
GO:0042301
GO:0042802
GO:0043101
GO:0043226
GO:0046059
GO:0046638
GO:0047975
GO:0048856
GO:0055086
GO:0070062
GO:1901135
GO:1904813
HMNXSV003001137
ILMN_2172174
K02574_at
PH_hs_0004336
TC14000056.hg
TC14001578.hg
g4557800_3p_a_at
Participates
as a member of
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
Other forms of this molecule
PNP R234P [cytosol]
PNP E89K [cytosol]
PNP D128G [cytosol]
PNP [secretory granule lumen]
PNP [extracellular region]
PNP [cytosol]
Inferred To
Homologues of PNP [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Homologues of PNP [ficolin-1-rich granule lumen]
(Mus musculus)
CG16760 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
PNP [ficolin-1-rich granule lumen]
(Bos taurus)
PNP [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
PNP [ficolin-1-rich granule lumen]
(Canis familiaris)
PNP [ficolin-1-rich granule lumen]
(Danio rerio)
PNP [ficolin-1-rich granule lumen]
(Mus musculus)
PNP [ficolin-1-rich granule lumen]
(Rattus norvegicus)
PNP [ficolin-1-rich granule lumen]
(Saccharomyces cerevisiae)
PNP [ficolin-1-rich granule lumen]
(Schizosaccharomyces pombe)
PNP [ficolin-1-rich granule lumen]
(Sus scrofa)
PNP [ficolin-1-rich granule lumen]
(Xenopus tropicalis)
Dmel\CG18128 [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
Cross References
RefSeq
NP_000261.2
Guide to Pharmacology - Targets
2841
OpenTargets
ENSG00000198805
ZINC - Substances
PNPH_HUMAN
ZINC target
P00491
ZINC - Biogenic
PNPH_HUMAN
PRO
P00491
PDB
3PHB
,
2OC9
,
1RCT
,
7ZSP
,
2A0Y
,
3BGS
,
1YRY
,
1ULA
,
3INY
,
1ULB
,
2Q7O
,
1PF7
,
7ZSO
,
1PWY
,
7ZSN
,
4EB8
,
1V45
,
2A0W
,
1V2H
,
1M73
,
2OC4
,
7ZSM
,
2A0X
,
1RFG
,
1V3Q
,
4EAR
,
3GB9
,
7ZSL
,
4ECE
,
4GKA
,
5ETJ
,
3K8Q
,
1RR6
,
5UGF
,
3D1V
,
1RT9
,
1RSZ
,
3K8O
,
2ON6
,
1V41
,
3GGS
ZINC - Investigational
PNPH_HUMAN
ZINC - Metabolites
PNPH_HUMAN
HPA
ENSG00000198805-PNP
GeneCards
P00491
Ensembl
ENSG00000198805
,
ENST00000361505
,
ENST00000697613
,
ENSP00000513359
,
ENSP00000354532
Pharos - Targets
P00491
ZINC - Predictions - Purchasable
PNPH_HUMAN
Orphanet
16560
HMDB Protein
HMDBP03752
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
9
UniProt:Q9BXM7 PINK1
5
p-S228,S402-PINK1 [mitochondrial outer membrane]
(R-HSA-9834051)
PINK1 [mitochondrial outer membrane]
(R-HSA-5205653)
PINK1 [mitochondrial intermembrane space]
(R-HSA-5205671)
PINK1 [cytosol]
(R-HSA-5205637)
PINK1(111-581) [mitochondrial intermembrane space]
(R-HSA-5205628)
0.556
3
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.556
3
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text