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MAPK14 [secretory granule lumen]
Stable Identifier
R-HSA-6803300
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
MAP kinase p38 alpha, Mitogen-activated protein kinase 14, MK14_HUMAN, p38 alpha
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
MAPK14 [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16539 MAPK14
Gene Names
MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A
Chain
initiator methionine:, chain:2-360
Reference Genes
COSMIC (genes):MAPK14 MAPK14
dbSNP Gene:1432 MAPK14
ENSEMBL:ENSG00000112062 MAPK14
Participates
as a member of
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
Other forms of this molecule
MAPK14 [ficolin-1-rich granule lumen]
MAPK14 [extracellular region]
MAPK14 [nucleoplasm]
MAPK14 [cytosol]
p-T180,Y182-MAPK14 [cytosol]
p-T180,Y182-MAPK14 [nucleoplasm]
Inferred To
gskl-2 [secretory granule lumen]
(Caenorhabditis elegans)
Homologues of MAPK14 [secretory granule lumen]
(Caenorhabditis elegans)
Homologues of MAPK14 [secretory granule lumen]
(Dictyostelium discoideum)
Homologues of MAPK14 [secretory granule lumen]
(Drosophila melanogaster)
MAPK14 [secretory granule lumen]
(Bos taurus)
MAPK14 [secretory granule lumen]
(Caenorhabditis elegans)
MAPK14 [secretory granule lumen]
(Canis familiaris)
MAPK14 [secretory granule lumen]
(Danio rerio)
MAPK14 [secretory granule lumen]
(Dictyostelium discoideum)
MAPK14 [secretory granule lumen]
(Drosophila melanogaster)
MAPK14 [secretory granule lumen]
(Gallus gallus)
MAPK14 [secretory granule lumen]
(Mus musculus)
MAPK14 [secretory granule lumen]
(Rattus norvegicus)
MAPK14 [secretory granule lumen]
(Saccharomyces cerevisiae)
MAPK14 [secretory granule lumen]
(Schizosaccharomyces pombe)
MAPK14 [secretory granule lumen]
(Sus scrofa)
MAPK14 [secretory granule lumen]
(Xenopus tropicalis)
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.93
15
UniProt:Q16644 MAPKAPK3
4
MAPKAPK3 [nucleoplasm]
(R-HSA-450218)
p-S,2T-MAPKAPK3 [nucleoplasm]
(R-HSA-450359)
p-S,2T-MAPKAPK3 [cytosol]
(R-HSA-187723)
MAPKAPK3 [cytosol]
(R-HSA-187764)
0.914
15
UniProt:O75676 RPS6KA4
1
RPS6KA4 [cytosol]
(R-HSA-772527)
0.829
9
UniProt:P46734 MAP2K3
3
MAP2K3 [cytosol]
(R-HSA-168051)
p-S218,T222-MAP2K3 [cytosol]
(R-HSA-167955)
p-S218,T222-MAP2K3 [nucleoplasm]
(R-HSA-450229)
0.802
7
UniProt:Q9BUB5 MKNK1
1
p-T250,T255,T385,S437-MKNK1 [cytosol]
(R-HSA-947860)
0.798
7
UniProt:Q9HBH9 MKNK2
0.788
5
UniProt:Q99956 DUSP9
1
DUSP9 [cytosol]
(R-HSA-5675351)
0.779
6
UniProt:P28562 DUSP1
1
DUSP1 [nucleoplasm]
(R-HSA-203796)
0.767
4
UniProt:Q8NEM7 SUPT20H
1
SUPT20H [nucleoplasm]
(R-HSA-3662286)
0.756
5
UniProt:O75147 OBSL1
1
OBSL1 [cytosol]
(R-HSA-8955929)
0.725
4
UniProt:O43257 ZNHI1
0.72
7
UniProt:Q15750 TAB1
6
TAB1 [cytosol]
(R-HSA-167923)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(445-504) [cytosol]
(R-HSA-9729691)
0.713
4
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.691
5
UniProt:Q15256 PTPRR
0.664
4
UniProt:Q9BY84 DUSP16
3
Ac-55-DUSP16 [cytosol]
(R-HSA-9636576)
DUSP16 [nucleoplasm]
(R-HSA-5675337)
DUSP16 [cytosol]
(R-HSA-5675336)
0.659
3
UniProt:Q9H0W5 CCDC8
1
CCDC8 [cytosol]
(R-HSA-8955915)
0.643
3
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.643
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.623
4
UniProt:Q16829 DUSP7
2
DUSP7 [cytosol]
(R-HSA-5675346)
DUSP7 [nucleoplasm]
(R-HSA-203791)
0.59
2
UniProt:P52564 MAP2K6
3
MAP2K6 [cytosol]
(R-HSA-167998)
p-S207,T211-MAP2K6 [cytosol]
(R-HSA-206255)
p-S207,T211-MAP2K6 [nucleoplasm]
(R-HSA-450258)
0.564
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:Q9H869 YYAP1
0.553
2
UniProt:Q15759 MAPK11
4
p-T180,Y182-MAPK11 [cytosol]
(R-HSA-171009)
MAPK11 [cytosol]
(R-HSA-170989)
MAPK11 [nucleoplasm]
(R-HSA-203790)
p-T180,Y182-MAPK11 [nucleoplasm]
(R-HSA-198741)
0.547
2
UniProt:Q6PJG2 MDEAS
0.547
2
UniProt:O75582 RPS6KA5
3
p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
(R-HSA-198683)
RPS6KA5 [nucleoplasm]
(R-HSA-198657)
RPS6KA5 [cytosol]
(R-HSA-772525)
0.547
3
UniProt:Q14814 MEF2D
1
MEF2D [nucleoplasm]
(R-HSA-445328)
0.547
2
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.547
3
UniProt:P51784 USP11
1
USP11 [cytosol]
(R-HSA-391303)
0.527
2
UniProt:P13639 EEF2
10
EEF2 [secretory granule lumen]
(R-HSA-6801504)
EEF2 [extracellular region]
(R-HSA-6806499)
EEF2 [ficolin-1-rich granule lumen]
(R-HSA-6801513)
EEF2 [cytosol]
(R-HSA-156901)
aminocarboxypropyl EEF2 [cytosol]
(R-HSA-5358478)
Me-diphthine EEF2 [cytosol]
(R-HSA-5367025)
nascent EEF2 [cytosol]
(R-HSA-5358472)
diphthine EEF2 [cytosol]
(R-HSA-5358501)
ADP-ribo-EEF2 [cytosol]
(R-HSA-5334764)
Me3K525-EEF2 [cytosol]
(R-HSA-8932237)
0.527
2
UniProt:Q96RR4 CAMKK2
4
p-CAMKK2 [nucleoplasm]
(R-HSA-9618968)
CAMKK2 [nucleoplasm]
(R-HSA-5336483)
p-CAMKK2 [cytosol]
(R-HSA-9619358)
CAMKK2 [cytosol]
(R-HSA-9619231)
0.527
2
UniProt:Q14999 CUL7
1
CUL7 [cytosol]
(R-HSA-535534)
0.527
2
UniProt:Q92574 TSC1
2
TSC1 [cytosol]
(R-HSA-5672338)
TSC1 [plasma membrane]
(R-HSA-165169)
0.508
2
UniProt:Q07352 ZFP36L1
3
p-S54,S92,S203-p-ZFP36L1 [cytosol]
(R-HSA-450384)
ZFP36L1 [cytosol]
(R-HSA-450547)
p-S92,S203-ZFP36L1 [cytosol]
(R-HSA-450618)
0.508
2
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