Reactome | TP53 binds the PCBP4 gene

TP53 binds the PCBP4 gene

Stable Identifier

R-HSA-6803391

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        TP53 binds the PCBP4 gene (Homo sapiens)

General

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TP53 (p53) binds two p53 response elements in the promoter of the PCBP4 (MCG10) gene (Zhu and Chen 2000).

Literature References

PubMed ID	Title	Journal	Year
10891498	MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M Zhu, J, Chen, X	Mol. Cell. Biol.	2000

Participants

Input

Output

p-S15,S20-TP53 Tetramer:PCBP4 Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-06)

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