Reactome | ESRP1 [nucleoplasm]

ESRP1 [nucleoplasm]

Stable Identifier

R-HSA-6803472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q6ZRY4 RBPS2

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External Reference Information

External Reference

UniProt:Q6NXG1 ESRP1

Gene Names

ESRP1, RBM35A

Chain

chain:1-681

Reference Genes

BioGPS Gene:54845 Q6NXG13

COSMIC (genes):ESRP1 ESRP1

CTD Gene:54845 Q6NXG13

dbSNP Gene:54845 ESRP1

ENSEMBL:ENSG00000104413 ESRP1

HGNC:25966 Q6NXG13

KEGG:hsa:54845 Q6NXG13

Monarch:54845 Q6NXG13

NCBI Gene:54845 Q6NXG13

OMIM:612959 Q6NXG13

UCSC:Q6NXG1 Q6NXG13

Reference Transcript

Participates

as a component of

FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)

as an input of

ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)

Other forms of this molecule

ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]

ESRP1(1-606)-RAF1(227-648) fusion [cytosol]

Inferred To

Esrp1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_060167.2, NP_001030087.2, XP_054216705.1, NP_001116297.1, XP_005251048.1, NP_001116298.1, NP_001116299.1

OpenTargets

ENSG00000104413

ENSEMBL

ENST00000358397, ENST00000433389, ENST00000646773, ENSP00000407349, ENSP00000351168, ENSP00000405738, ENSP00000494213, ENSG00000104413, ENST00000423620

GeneCards

ESRP1

HPA

ENSG00000104413-ESRP1

PRO

Q6NXG1

Pharos - Targets

Q6NXG1

PDB

2RVJ, 2DHA, 7VKI, 7VKJ, 7WRN

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.805	12
UniProt:Q6ZRY4 RBPS2			0.742	5
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:P02766 TTR	2	TTR [extracellular region] (R-HSA-976883) TTR [azurophil granule lumen] (R-HSA-6799366)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:P00488 F13A1	4	F13A1(1-732) [platelet alpha granule lumen] (R-HSA-349759) F13A1(1-731) [extracellular region] (R-HSA-140600) F13A1(38-731) [extracellular region] (R-HSA-140788) F13A1(1-37) [extracellular region] (R-HSA-140790)	0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.556	3
UniProt:P86480 PR20D			0.556	3
UniProt:Q13393 PLD1	4	PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [tertiary granule membrane] (R-HSA-6800955)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) SDC2 [Golgi lumen] (R-HSA-2054101) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P08670 VIM	12	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) p39-VIM [cytosol] (R-HSA-9948102)	0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q15038 DAZP2			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q96G42 KLD7B			0.556	3
IntAct:EBI-25857482 CCSB			0.556	3
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:P13637 ATP1A3	1	ATP1A3 [plasma membrane] (R-HSA-936803)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q99666 RGPD5			0.527	2
UniProt:O14715 RGPD8			0.527	2