Reactome | PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA

Stable Identifier

R-HSA-6803523

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA

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Repression of FGFR2 exon IIIb splicing in mesenchymal cells depends on intronic splicing silencer (ISS) sequences upstream of exon IIIb as well as an exonic splicing element (ESE) within exon IIIb. These elements are bound by PTB1 and hnRNPA1, respectively, as part of a larger splicing complex, promoting the formation and expression of mature FGFR2c mRNA in mesenchymal cells (Carstens et al, 2000; Gil et al, 1991; Del Gatto et al, 1997; Del Gatto et al, 1999). For more detailed information on splicing and pre-mRNA maturation, please see the mRNA splicing pathway.

Literature References

PubMed ID	Title	Journal	Year
9858549	hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer Olive, M, Del Gatto-Konczak, F, Gesnel, MC, Breathnach, R	Mol. Cell. Biol.	1999
10982855	An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein Garcia-Blanco, MA, Carstens, RP, Wagner, EJ	Mol. Cell. Biol.	2000
1906035	Characterization of cDNAs encoding the polypyrimidine tract-binding protein Garcia-Blanco, MA, Jamison, SF, Sharp, PA, Gil, A	Genes Dev.	1991
9271388	Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon Fort, C, Del Gatto, F, Gesnel, MC, Breathnach, R, Plet, A	Mol. Cell. Biol.	1997