CHEK2 phosphorylates TTC5

Stable Identifier
R-HSA-6804266
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CHEK2 phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S221, resulting in TTC5 stabilization through an unknown mechanism (Adams et al. 2008).

Literature References
PubMed ID Title Journal Year
18833288 ATM and Chk2 kinase target the p53 cofactor Strap

Adams, CJ, Graham, AL, Jansson, M, Coutts, AS, Edelmann, M, Smith, L, Kessler, B, La Thangue, NB

EMBO Rep. 2008
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]

Orthologous Events
Authored
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Created
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