CHEK2 phosphorylates TTC5

Stable Identifier
R-HSA-6804266
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CHEK2 phosphorylates TTC5
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CHEK2 phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S221, resulting in TTC5 stabilization through an unknown mechanism (Adams et al. 2008).

Literature References
PubMed ID Title Journal Year
18833288 ATM and Chk2 kinase target the p53 cofactor Strap

Coutts, AS, Smith, L, Adams, CJ, Edelmann, M, Jansson, M, La Thangue, NB, Kessler, B, Graham, AL

EMBO Rep. 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]

Physical Entity
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CHEK2 phosphorylates TTC5 (Bos taurus)
CHEK2 phosphorylates TTC5 (Caenorhabditis elegans)
CHEK2 phosphorylates TTC5 (Danio rerio)
CHEK2 phosphorylates TTC5 (Dictyostelium discoideum)
CHEK2 phosphorylates TTC5 (Mus musculus)
CHEK2 phosphorylates TTC5 (Rattus norvegicus)
CHEK2 phosphorylates TTC5 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-09)
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