ATM phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S203. Phosphorylation of S203 induces nuclear accumulation of TTC5, probably by interfering with the nuclear export signal at the N-terminus of TTC5 (Demonacos et al. 2004, Adams et al. 2008).
Smith, L, Xu, D, Jansson, M, La Thangue, NB, Krstic-Demonacos, M, O'Connor, DP, Demonacos, C
Coutts, AS, Smith, L, Adams, CJ, Edelmann, M, Jansson, M, La Thangue, NB, Kessler, B, Graham, AL
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
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