ATM phosphorylates TTC5

Stable Identifier
R-HSA-6804276
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ATM phosphorylates TTC5
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ATM phosphorylates TTC5 (Strap), a cofactor of TP53 (p53), on serine residue S203. Phosphorylation of S203 induces nuclear accumulation of TTC5, probably by interfering with the nuclear export signal at the N-terminus of TTC5 (Demonacos et al. 2004, Adams et al. 2008).
Literature References
PubMed ID Title Journal Year
15448695 A new effector pathway links ATM kinase with the DNA damage response

Smith, L, Xu, D, Jansson, M, La Thangue, NB, Krstic-Demonacos, M, O'Connor, DP, Demonacos, C

Nat. Cell Biol. 2004
18833288 ATM and Chk2 kinase target the p53 cofactor Strap

Coutts, AS, Smith, L, Adams, CJ, Edelmann, M, Jansson, M, La Thangue, NB, Kessler, B, Graham, AL

EMBO Rep. 2008
Participants
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Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]

Physical Entity
p-S1981,Ac-K3016-ATM [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
ATM phosphorylates TTC5 (Bos taurus)
ATM phosphorylates TTC5 (Canis familiaris)
ATM phosphorylates TTC5 (Dictyostelium discoideum)
ATM phosphorylates TTC5 (Mus musculus)
ATM phosphorylates TTC5 (Rattus norvegicus)
ATM phosphorylates TTC5 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-09)
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