Reactome | POU4F2 [nucleoplasm]

POU4F2 [nucleoplasm]

Stable Identifier

R-HSA-6804414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

POU domain, class 4, transcription factor 2, Brain-specific homeobox/POU domain protein 3B, BRN3B, Brn-3B, Brain-3B

Icon

Locations in the PathwayBrowser for interactor UniProt:Q9C004 SPY4

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        TP53 binds POU4F2 (Homo sapiens)
        
        POU4F2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12837 POU4F2

Gene Names

POU4F2, BRN3B

Chain

chain:1-409

Reference Genes

BioGPS Gene:5458 POU4F2

COSMIC (genes):POU4F2 POU4F2

CTD Gene:5458 POU4F2

dbSNP Gene:5458 POU4F2

ENSEMBL:ENSG00000151615 POU4F2

ENSEMBL_homo_sapiens_GENE:ENSG00000151615.3 POU4F2

HGNC:9219 POU4F2

KEGG Gene (Homo sapiens):5458 POU4F2

Monarch:5458 POU4F2

NCBI Gene:5458 POU4F2

OMIM:113725 POU4F2

UCSC:Q12837 POU4F2

Reference Transcript

RefSeq:NM_004575.2 POU4F2

Other Identifiers

11734376_at

11734377_at

16971256

207725_PM_at

207725_at

2746423

2746424

2746425

2746428

2746429

2746430

2746431

2746432

2746433

2746434

34551_at

5458

8097687

A_14_P136639

A_14_P202446

A_23_P302038

GE81413

GO:0000122

GO:0000165

GO:0000785

GO:0000791

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0002039

GO:0002376

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0006915

GO:0007283

GO:0007409

GO:0007411

GO:0007507

GO:0007605

GO:0010468

GO:0010666

GO:0012501

GO:0016607

GO:0022414

GO:0023052

GO:0030154

GO:0030182

GO:0030520

GO:0031290

GO:0032869

GO:0043068

GO:0043226

GO:0043433

GO:0043565

GO:0045596

GO:0045597

GO:0045672

GO:0045773

GO:0045944

GO:0046326

GO:0048675

GO:0048856

GO:0050877

GO:0050885

GO:0051090

GO:0055085

GO:0060041

GO:0071345

GO:0071392

GO:0071453

GO:0072332

GO:0090259

GO:0140110

GO:1902870

GO:1904178

GO:1990791

GO:1990841

GO:2000679

HMNXSV003000910

ILMN_1740035

PH_hs_0030849

TC04000724.hg

U06233_at

g4758947_3p_at

Participates

as a component of

p-S15,S20-TP53 Tetramer:POU4F2 [nucleoplasm] (Homo sapiens)

as an input of

TP53 binds POU4F2 (Homo sapiens)

Inferred To

Pou4f2 [nucleoplasm] (Mus musculus)

Pou4f2 [nucleoplasm] (Rattus norvegicus)

Homologues of POU4F2 [nucleoplasm] (Caenorhabditis elegans)

POU4F2 [nucleoplasm] (Bos taurus)

POU4F2 [nucleoplasm] (Canis familiaris)

POU4F2 [nucleoplasm] (Gallus gallus)

POU4F2 [nucleoplasm] (Sus scrofa)

pou4f2 [nucleoplasm] (Danio rerio)

pou4f2 [nucleoplasm] (Xenopus tropicalis)

acj6 [nucleoplasm] (Drosophila melanogaster)

unc-86 [nucleoplasm] (Caenorhabditis elegans)

ceh-18 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004566.2

OpenTargets

ENSG00000151615

GeneCards

Q12837

HPA

ENSG00000151615-POU4F2

Ensembl

ENSG00000151615, ENST00000281321, ENSP00000281321

PRO

Q12837

Pharos - Targets

Q12837

Interactors (74)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:O60479 DLX3			0.556	3
UniProt:Q9BQ66 KR412			0.556	3
UniProt:P10745 RBP3	1	RBP3 [extracellular region] (R-HSA-2984190)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	5
UniProt:Q9BYR2 KRTAP4-5	1	KRTAP4-5 [cytosol] (R-HSA-6809950)	0.556	3
UniProt:Q9BYR3 KRTAP4-4	1	KRTAP4-4 [cytosol] (R-HSA-6809966)	0.556	3
UniProt:P27658 COL8A1	20	3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173246) GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173055) 3x4Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173183) 3x4Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173195) 3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173270) GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173122) COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172239) 3x4Hyp-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172948) 3x4Hyp-3Hyp-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2172976) 3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173143) 3x4Hyp-3Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173217) 5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen] (R-HSA-2173023) 3x4Hyp-3Hyp-COL8A1(28-?) [extracellular region] (R-HSA-2470362) GalHyl-COL8A1(?-744) [extracellular region] (R-HSA-2470331) 3x4Hyp-3Hyp-COL8A1(?-744) [extracellular region] (R-HSA-2470328) 3x4Hyp-3Hyp-GalHyl-COL8A1(?-744) [extracellular region] (R-HSA-2470329) 3x4Hyp-5Hyl-COL8A1(?-744) [extracellular region] (R-HSA-2470366) GalHyl-COL8A1(28-?) [extracellular region] (R-HSA-2470364) 5Hyl-COL8A1(?-744) [extracellular region] (R-HSA-2470333) COL8A1(?-744) [extracellular region] (R-HSA-2470355)	0.556	5
UniProt:Q8IWZ5 TRI42			0.556	5
UniProt:Q9NRY7 PLS2			0.556	5
UniProt:Q9BYR7 KRTAP3-2	1	KRTAP3-2 [cytosol] (R-HSA-6809857)	0.556	5
UniProt:Q9UKJ5 CHIC2			0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q3LI70 KRTAP19-6	1	KRTAP19-6 [cytosol] (R-HSA-6810286)	0.556	3
UniProt:P60329 KRTAP12-4	1	KRTAP12-4 [cytosol] (R-HSA-6810278)	0.556	3
UniProt:Q9H2X0 CHRD			0.556	3
UniProt:Q3SYF9 KRTAP19-7	1	KRTAP19-7 [cytosol] (R-HSA-6810305)	0.556	3
UniProt:P15529-3 CD46			0.556	3
UniProt:Q8NI38 IKBD			0.556	3
UniProt:Q3LHN2 KRTAP19-2	1	KRTAP19-2 [cytosol] (R-HSA-6810262)	0.556	3
UniProt:P80188 LCN2	2	LCN2 [specific granule lumen] (R-HSA-6799614) LCN2 [extracellular region] (R-HSA-5215934)	0.556	3
UniProt:Q6UXB3 LYPD2	2	cleaved GPI-LYPD2 [extracellular region] (R-HSA-8941044) GPI-LYPD2 [plasma membrane] (R-HSA-8940734)	0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q5T4B2 GT253			0.556	3
UniProt:Q6UW32 IGFL1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:P59991 KRTAP12-2	1	KRTAP12-2 [cytosol] (R-HSA-6810271)	0.556	3
UniProt:Q4VC39 HIG2B			0.556	3
UniProt:Q9H3L0 MMADHC	8	MMADHC [cytosol] (R-HSA-3149529) MMADHC R250* [cytosol] (R-HSA-3318608) MMADHC T182N [cytosol] (R-HSA-3318599) MMADHC L259P [cytosol] (R-HSA-3318587) MMADHC Y249C [cytosol] (R-HSA-3318584) MMADHC Y140* [cytosol] (R-HSA-3318633) MMADHC R54* [cytosol] (R-HSA-3318620) MMADHC S20* [cytosol] (R-HSA-3318573)	0.556	3
UniProt:Q9C004 SPY4			0.556	3
UniProt:Q08AG9 Q08AG9			0.556	3
UniProt:P50458 LHX2	1	LHX2 [nucleoplasm] (R-HSA-9011100)	0.556	3
UniProt:Q92824-2 PCSK5			0.556	6
UniProt:Q9BSH5 HDHD3			0.556	3
UniProt:Q9UHV8 PP13			0.556	3
UniProt:P78385 KRT83	1	KRT83 [cytosol] (R-HSA-6809636)	0.556	3
UniProt:Q5TCM9 LCE5A	1	LCE5A [cytosol] (R-HSA-6814260)	0.556	3
UniProt:Q3LI59 KRTAP21-2	1	KRTAP21-2 [cytosol] (R-HSA-6810245)	0.556	3
UniProt:Q5T751 LCE1C	1	LCE1C [cytosol] (R-HSA-6814267)	0.556	3
UniProt:P60412 KRTAP10-11	1	KRTAP10-11 [cytosol] (R-HSA-6810243)	0.556	3
UniProt:P05187 ALPP	1	ALPP [transport vesicle] (R-HSA-8847823)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	6
UniProt:Q3SY46 KRTAP13-3	1	KRTAP13-3 [cytosol] (R-HSA-6810267)	0.556	3
UniProt:A8MTQ0 NOTO	1	NOTO [nucleoplasm] (R-HSA-9796216)	0.556	3
UniProt:P59990 KRTAP12-1	1	KRTAP12-1 [cytosol] (R-HSA-6810248)	0.556	3
UniProt:Q93062-3 RBPMS			0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	6
UniProt:Q9BYQ3 KRTAP9-3	1	KRTAP9-3 [cytosol] (R-HSA-6809954)	0.556	3
IntAct:EBI-16435576 CCSB ORF ID			0.556	3
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.556	3
UniProt:P48745 CCN3			0.556	3
UniProt:Q9NVL1-2 FAM86C1P			0.556	5
UniProt:Q6WN34-2 CHRDL2			0.556	3
UniProt:P49795 RGS19	1	RGS19 [plasma membrane] (R-HSA-921129)	0.556	3
UniProt:Q9BYQ0 KRTAP9-8	1	KRTAP9-8 [cytosol] (R-HSA-6809953)	0.556	3
UniProt:Q6L8H2 KRTAP5-3	1	KRTAP5-3 [cytosol] (R-HSA-6810259)	0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	6
UniProt:Q6L8H1 KRTAP5-4	1	KRTAP5-4 [cytosol] (R-HSA-6810264)	0.556	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.556	3
IntAct:EBI-16436789 CCSB ORF ID			0.556	5
UniProt:P60370 KRTAP10-5	1	KRTAP10-5 [cytosol] (R-HSA-6810260)	0.556	3
UniProt:O76015 KRT38	1	KRT38 [cytosol] (R-HSA-6809615)	0.556	3
UniProt:Q6L8G4 KRTAP5-11	1	KRTAP5-11 [cytosol] (R-HSA-6810303)	0.556	3
UniProt:Q2TAL6 VWC2			0.556	3
UniProt:Q5T754 LCE1F	1	LCE1F [cytosol] (R-HSA-6814270)	0.556	3
UniProt:Q6L8G9 KRTAP5-6	1	KRTAP5-6 [cytosol] (R-HSA-6810276)	0.556	3

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