Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
polySUMO2-K551-SP3 [nucleoplasm]
Stable Identifier
R-HSA-6804456
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor Sp3, SP3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)
polySUMO2-K551-SP3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02447 SP3
Gene Names
SP3
Chain
chain:1-781
Reference Genes
BioGPS Gene:6670 SP3
COSMIC (genes):SP3 SP3
CTD Gene:6670 SP3
dbSNP Gene:6670 SP3
ENSEMBL:ENSG00000172845 SP3
ENSEMBL_homo_sapiens_GENE:ENSG00000172845.18 SP3
HGNC:11208 SP3
KEGG Gene (Homo sapiens):6670 SP3
Monarch:6670 SP3
NCBI Gene:6670 SP3
OMIM:601804 SP3
UCSC:Q02447 SP3
Reference Transcript
RefSeq:NM_001172712.1 SP3
RefSeq:NM_003111.4 SP3
RefSeq:NM_001017371.4 SP3
Other Identifiers
11723294_x_at
11731618_a_at
11731619_x_at
11758883_at
11759066_at
11761980_a_at
16905163
213168_PM_at
213168_at
229217_PM_at
229217_at
232709_PM_at
232709_at
238035_PM_at
238035_at
2587523
2587524
2587525
2587526
2587527
2587530
2587531
2587533
2587534
2587548
2587553
2587554
2587555
2587556
2587557
2587558
2587591
2587592
2587608
2587610
2587612
3520184
41573_at
42046_at
6670
8056798
81493_at
90572_at
A_23_P347198
A_24_P58283
A_32_P20240
GE59947
GE903009
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001227
GO:0001503
GO:0001701
GO:0001779
GO:0001829
GO:0001889
GO:0001892
GO:0002318
GO:0002376
GO:0003677
GO:0003682
GO:0003690
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0016605
GO:0017053
GO:0022414
GO:0030154
GO:0030183
GO:0030217
GO:0030218
GO:0030219
GO:0030224
GO:0030324
GO:0030851
GO:0032993
GO:0043226
GO:0043353
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0048596
GO:0048706
GO:0048856
GO:0060136
GO:0060216
GO:0061629
GO:0140110
GO:1990837
HMNXSV003054035
Hs.120770.0.A1_3p_at
Hs.154295.0.A1_3p_at
Hs.154295.0.A1_3p_x_at
Hs.44450.1.A1_3p_at
Hs.88605.0.S1_3p_at
ILMN_1662168
ILMN_1691171
ILMN_1756942
ILMN_2389844
PH_hs_0004957
TC02002535.hg
TC02004696.hg
X68560_at
Participates
as an output of
PIAS1 SUMOylates SP3 with SUMO2 (Homo sapiens)
Other forms of this molecule
monoSUMO1-K551-SP3 [nucleoplasm]
SP3 [nucleoplasm]
Inferred To
Sp3 [nucleoplasm]
(Mus musculus)
Sp3 [nucleoplasm]
(Rattus norvegicus)
Spps [nucleoplasm]
(Drosophila melanogaster)
SP3 [nucleoplasm]
(Bos taurus)
SP3 [nucleoplasm]
(Gallus gallus)
SP3 [nucleoplasm]
(Sus scrofa)
sp4 [nucleoplasm]
(Danio rerio)
Modified Residues
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 551
Coordinate
551
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001017371.3
,
NP_003102.1
,
NP_001166183.1
OpenTargets
ENSG00000172845
GeneCards
Q02447
HPA
ENSG00000172845-SP3
Ensembl
ENSP00000310301
,
ENST00000310015
,
ENSG00000172845
,
ENSP00000406140
,
ENST00000418194
PRO
Q02447
Pharos - Targets
Q02447
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.667
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q6MZP7 LIN54
1
LIN54 [nucleoplasm]
(R-HSA-389103)
0.556
3
UniProt:Q96BD5 PHF21A
1
PHF21A [nucleoplasm]
(R-HSA-996754)
0.556
3
UniProt:P14678-2 SNRPB
0.556
3
UniProt:Q7Z3K3 POGZ
0.556
3
UniProt:Q96Q77 CIB3
0.556
3
UniProt:Q5MJ10 SPXN2
0.556
3
UniProt:Q06546 GABPA
1
GABPA [nucleoplasm]
(R-HSA-1592206)
0.544
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text