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CITED2 [nucleoplasm]
Stable Identifier
R-HSA-6804489
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cbp/p300-interacting transactivator 2, CITE2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Regulation of gene expression by Hypoxia-inducible Factor (Homo sapiens)
Formation of HIF:CBP:p300 complex at promoters (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
Activation of the TFAP2 (AP-2) family of transcription factors (Homo sapiens)
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP (Homo sapiens)
CITED2,CITED4,(CITED1) [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2 homo- and heterodimers:CITED2,CITED4,(CITED1):EP300:CREBBP [nucleoplasm] (Homo sapiens)
CITED2,CITED4,(CITED1) [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of other transcription factors (Homo sapiens)
PITX2 gene expression is stimulated by TFAP2A,TFAP2C homodimers:CITED2 (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2:PITX2 Gene [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2:PITX2 Gene [nucleoplasm] (Homo sapiens)
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
CITED2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
8901575
msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation
Shioda, T
,
Isselbacher, KJ
,
Fenner, MH
Proc. Natl. Acad. Sci. U.S.A.
1996
External Reference Information
External Reference
UniProt:Q99967 CITED2
Gene Names
CITED2, MRG1
Chain
chain:1-270
Reference Genes
BioGPS Gene:10370 CITED2
COSMIC (genes):CITED2 CITED2
CTD Gene:10370 CITED2
dbSNP Gene:10370 CITED2
ENSEMBL:ENSG00000164442 CITED2
HGNC:1987 CITED2
KEGG:hsa:10370 CITED2
Monarch:10370 CITED2
NCBI Gene:10370 CITED2
OMIM:602937 CITED2
UCSC:Q99967 CITED2
Reference Transcript
RefSeq:NM_001168388.2 CITED2
RefSeq:NM_001168389.2 CITED2
RefSeq:NM_006079.4 CITED2
Other Identifiers
10370
11716210_at
11753421_a_at
17024285
207980_PM_s_at
207980_s_at
209357_PM_at
209357_at
2976771
2976772
2976773
2976774
2976775
2976776
2976777
2976778
2976779
2976780
2976782
2976783
2976784
2976785
2976786
33113_at
8129937
A_23_P214969
A_33_P3213374
GE54814
GO:0000122
GO:0000785
GO:0001568
GO:0001570
GO:0001666
GO:0001701
GO:0001829
GO:0001841
GO:0001843
GO:0001889
GO:0001892
GO:0001944
GO:0001947
GO:0002089
GO:0002244
GO:0002521
GO:0003140
GO:0003151
GO:0003156
GO:0003197
GO:0003281
GO:0003682
GO:0003713
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0007179
GO:0007368
GO:0007417
GO:0007422
GO:0007507
GO:0007530
GO:0008283
GO:0008584
GO:0009612
GO:0010628
GO:0010629
GO:0019904
GO:0021602
GO:0022409
GO:0022414
GO:0030154
GO:0030325
GO:0030336
GO:0030511
GO:0030851
GO:0032991
GO:0034405
GO:0035035
GO:0035360
GO:0035802
GO:0035914
GO:0038092
GO:0043066
GO:0043226
GO:0043231
GO:0043627
GO:0045787
GO:0045892
GO:0045893
GO:0045944
GO:0046332
GO:0046697
GO:0048536
GO:0048538
GO:0048596
GO:0048821
GO:0048856
GO:0050693
GO:0060044
GO:0060065
GO:0060090
GO:0060136
GO:0060349
GO:0060411
GO:0060412
GO:0060971
GO:0060972
GO:0061156
GO:0061308
GO:0061371
GO:0061629
GO:0070986
GO:0071363
GO:0071456
GO:0090398
GO:0098772
GO:0140110
GO:0140677
GO:2000020
HMNXSV003057657
ILMN_1663092
PH_hs_0004690
PH_hs_0031364
TC06002168.hg
U65093_at
g4193945_3p_at
g5174416_3p_a_at
Participates
as an output of
CITED2 gene expression is stimulated by FOXO1,FOXO3 (Homo sapiens)
as a component of
TFAP2A,TFAP2C homodimers:CITED2 [nucleoplasm] (Homo sapiens)
as a member of
CITED2,CITED4,(CITED1) [nucleoplasm] (Homo sapiens)
This entity regulates
Negatively
Formation of HIF:CBP:p300 complex at promoters
(Homo sapiens)
Inferred To
cited2 [nucleoplasm]
(Danio rerio)
cited2 [nucleoplasm]
(Xenopus tropicalis)
CITED2 [nucleoplasm]
(Bos taurus)
CITED2 [nucleoplasm]
(Canis familiaris)
CITED2 [nucleoplasm]
(Gallus gallus)
CITED2 [nucleoplasm]
(Sus scrofa)
Cited2 [nucleoplasm]
(Mus musculus)
Cited2 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000442831
,
ENST00000536159
,
ENSP00000356623
,
ENST00000367651
OpenTargets
ENSG00000164442
HPA
ENSG00000164442-CITED2
PRO
Q99967
Pharos - Targets
Q99967
Orphanet
CITED2
HMDB Protein
HMDBP14508
PDB
1P4Q
,
1R8U
,
7LVS
,
7QGS
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P60891 PRPS1
1
PRPS1 [cytosol]
(R-HSA-73483)
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:P41235 HNF4A
1
HNF4A [nucleoplasm]
(R-HSA-446162)
0.543
3
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.508
3
UniProt:Q92754 TFAP2C
3
monoSUMO1-K10-TFAP2C [nucleoplasm]
(R-HSA-3234071)
TFAP2C [cytosol]
(R-HSA-8864579)
TFAP2C [nucleoplasm]
(R-HSA-3234058)
0.508
2
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