Reactome | APAF1:CYCS binds APIP

APAF1:CYCS binds APIP

Stable Identifier

R-HSA-6804596

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - Cytochrome c-mediated apoptotic response (Homo sapiens)
        
        Formation of apoptosome (Homo sapiens)
        
        Regulation of the apoptosome activity (Homo sapiens)
        
        APAF1:CYCS binds APIP (Homo sapiens)

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The APAF1 interacting protein (APIP) is an endogenous regulators of the apoptosome apparatus. APIP is thought to bind to the CARD domain of APAF1 preventing procaspase-9 recruitment to the apoptosome (Cho DH et al., 2004; Cao G et al., 2004; Kang W et al. 2014). Moreover, during hypoxic conditions, APIP may also induce sustained activation of AKT and ERK1/2 kinases, which directly phosphorylate procaspase-9 to inhibit its activation in the apoptosome (Cho DH et al., 2007).

Literature References

PubMed ID	Title	Journal	Year
24367089	Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme Kim, TY, Yang, JK, Kim, HC, Ashida, H, Yokota, A, Le, le TM, Jung, YK, Lee, HM, Chun, KH, Hong, SH, Hah, SS, Lim, YC, Lim, B, Kim, NY, Kang, W	Proc. Natl. Acad. Sci. U.S.A.	2014