Reactome | CD53 [specific granule membrane]

CD53 [specific granule membrane]

Stable Identifier

R-HSA-6804793

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule membrane

Synonyms

Leukocyte surface antigen CD53, CD53_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P19397 CD53

Gene Names

CD53, MOX44, TSPAN25

Chain

chain:1-219

Reference Genes

BioGPS Gene:963 CD53

COSMIC (genes):CD53 CD53

CTD Gene:963 CD53

dbSNP Gene:963 CD53

ENSEMBL:ENSG00000143119 CD53

HGNC:1686 CD53

KEGG:hsa:963 CD53

Monarch:963 CD53

NCBI Gene:963 CD53

OMIM:151525 CD53

UCSC:P19397 CD53

Reference Transcript

Other Identifiers

11716842_a_at

11753555_a_at

16668582

203416_PM_at

203416_at

2351573

2351574

2351575

2351578

2351579

2351581

2351582

2351583

2351584

2351585

2351587

2351589

2351590

2351593

2351594

242946_PM_at

242946_at

38378_at

59847_at

7903893

963

A_14_P103836

GE57954

GO:0001772

GO:0005515

GO:0005886

GO:0005911

GO:0007165

GO:0009986

GO:0016020

GO:0035579

GO:0042802

GO:0043113

GO:0043226

GO:0043495

GO:0045202

GO:0060090

GO:0070062

GO:0070161

GO:0070821

GO:1901741

HMNXSV003015941

ILMN_1662843

ILMN_2413808

M37033_at

PH_hs_0025876

TC01000968.hg

g10834971_3p_at

Participates

as a member of

Specific granule membrane proteins [specific granule membrane] (Homo sapiens)

Other forms of this molecule

CD53 [tertiary granule membrane]

CD53 [plasma membrane]

Inferred To

Cd53 [specific granule membrane] (Mus musculus)

Cd53 [specific granule membrane] (Rattus norvegicus)

tspan9 [specific granule membrane] (Danio rerio)

Tsp42Eo [specific granule membrane] (Drosophila melanogaster)

tsp-6 [specific granule membrane] (Caenorhabditis elegans)

tsp-4 [specific granule membrane] (Caenorhabditis elegans)

Tsp2A [specific granule membrane] (Drosophila melanogaster)

Homologues of CD53 [specific granule membrane] (Caenorhabditis elegans)

Homologues of CD53 [specific granule membrane] (Drosophila melanogaster)

lbm [specific granule membrane] (Drosophila melanogaster)

tsp-15 [specific granule membrane] (Caenorhabditis elegans)

Tsp68C [specific granule membrane] (Drosophila melanogaster)

Tsp5D [specific granule membrane] (Drosophila melanogaster)

tsp-20 [specific granule membrane] (Caenorhabditis elegans)

CD53 [specific granule membrane] (Bos taurus)

CD53 [specific granule membrane] (Canis familiaris)

CD53 [specific granule membrane] (Sus scrofa)

tsp-5 [specific granule membrane] (Caenorhabditis elegans)

cd53 [specific granule membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000271324, ENST00000648608, ENST00000271324, ENSP00000497382

OpenTargets

ENSG00000143119

HPA

ENSG00000143119-CD53

PRO

P19397

Pharos - Targets

P19397

GlyGen

P19397

PDB

6WVG

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:Q01628 IFITM3	1	IFITM3 [plasma membrane] (R-HSA-1015688)	0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	5
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3
UniProt:P78382 SLC35A1	2	SLC35A1 [Golgi membrane] (R-HSA-727812) SLC35A1 V93Cfs*17 [Golgi membrane] (R-HSA-5651957)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:O43561-2 LAT	2	p-5Y-LAT-2 [plasma membrane] (R-HSA-2396597) LAT-2 [plasma membrane] (R-HSA-2396548)	0.556	3
UniProt:O95406 CNIH1	3	CNIH1 [endoplasmic reticulum membrane] (R-HSA-5689439) CNIH1 [ER to Golgi transport vesicle membrane] (R-HSA-5689776) CNIH1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689778)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3

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