Reactome | RAP1B [azurophil granule membrane]

RAP1B [azurophil granule membrane]

Stable Identifier

R-HSA-6804972

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule membrane

Synonyms

Ras-related protein Rap-1B

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Locations in the PathwayBrowser for interactor UniProt:Q8TBJ4 PLPPR1

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of Ras-related protein Rap-1b (Homo sapiens)
        
        RAP1B [azurophil granule membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61224 RAP1B

Gene Names

RAP1B, OK/SW-cl.11

Chain

chain:1-181, propeptide:182-184

Reference Genes

BioGPS Gene:5908 RAP1B

COSMIC (genes):RAP1B RAP1B

CTD Gene:5908 RAP1B

dbSNP Gene:5908 RAP1B

ENSEMBL:ENSG00000127314 RAP1B

HGNC:9857 RAP1B

KEGG:hsa:5908 RAP1B

Monarch:5908 RAP1B

NCBI Gene:5908 RAP1B

OMIM:179530 RAP1B

UCSC:P61224 RAP1B

Reference Transcript

Other Identifiers

11716883_s_at

11747247_x_at

11753055_s_at

11753623_s_at

11762914_at

1903_at

200833_PM_s_at

200833_s_at

2863204

2863205

2863206

2863207

2863208

2863209

2863211

3421119

3421124

3421133

3421134

3421135

3421136

3421137

3421138

3421140

3421141

3421142

3421143

3421144

3421145

3421146

3421147

3421148

3421149

3421150

3421151

3421152

3421153

3421154

3421155

3421156

3421157

3421168

3421170

3421172

40146_at

5908

7956937

8112728

A_14_P109280

A_23_P2661

A_33_P3211604

GE56363

GE86861

GO:0000166

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005737

GO:0005811

GO:0005829

GO:0005886

GO:0005911

GO:0007165

GO:0007264

GO:0008283

GO:0016020

GO:0016192

GO:0016787

GO:0017156

GO:0019003

GO:0032486

GO:0033625

GO:0034330

GO:0035577

GO:0043226

GO:0044877

GO:0045955

GO:0048856

GO:0051649

GO:0061028

GO:0070062

GO:0070161

GO:0070374

GO:0071320

GO:0098772

GO:0098978

GO:0099010

GO:1901888

GO:2000114

GO:2000301

HMNXSV003030700

ILMN_1701434

ILMN_2398474

PH_hs_0027411

TC05001498.hg

TC05003091.hg

TC12000601.hg

g7661677_3p_a_at

Participates

as an output of

Expression of Ras-related protein Rap-1b (Homo sapiens)

as a member of

Azurophil granule membrane proteins [azurophil granule membrane] (Homo sapiens)

Other forms of this molecule

RAP1B [plasma membrane]

Inferred To

RAP1B [azurophil granule membrane] (Bos taurus)

RAP1B [azurophil granule membrane] (Caenorhabditis elegans)

RAP1B [azurophil granule membrane] (Canis familiaris)

RAP1B [azurophil granule membrane] (Danio rerio)

RAP1B [azurophil granule membrane] (Dictyostelium discoideum)

RAP1B [azurophil granule membrane] (Drosophila melanogaster)

RAP1B [azurophil granule membrane] (Gallus gallus)

RAP1B [azurophil granule membrane] (Mus musculus)

RAP1B [azurophil granule membrane] (Rattus norvegicus)

RAP1B [azurophil granule membrane] (Saccharomyces cerevisiae)

RAP1B [azurophil granule membrane] (Sus scrofa)

RAP1B [azurophil granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001238847.1, NP_001238846.1, NP_056461.1, NP_001238851.1, NP_001238850.1, NP_001010942.1

OpenTargets

ENSG00000127314

ENSEMBL

ENSP00000439966, ENST00000341355, ENSP00000440014, ENST00000540209, ENSP00000441275, ENSP00000377085, ENST00000539091, ENSP00000250559, ENST00000537460, ENST00000393436, ENSP00000399986, ENST00000542145, ENSP00000446318, ENSP00000444830, ENST00000450214, ENST00000250559

IntEnz

3.6.5.2

HPA

ENSG00000127314-RAP1B

PRO

P61224

Pharos - Targets

P61224

GlyGen

P61224

HMDB Protein

HMDBP08162

PDB

4MGZ, 4DXA, 4MGY, 6AXF, 4HDQ, 4MH0, 5KHO, 3BRW, 6OQ3, 4MGI, 4M8N, 8T7V, 6UZK, 8T09, 6KYK, 4HDO, 7C7J, 8SU8, 6OQ4, 7C7I, 4MGK, 3CF6, 6BA6

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9EQZ6-3 RAPGEF4			0.663	3
UniProt:Q12967 RALGDS	1	RALGDS [cytosol] (R-HSA-171001)	0.573	2
UniProt:Q12967-6 RALGDS			0.556	3
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:Q8TDX7 NEK7	2	NEK7 [cytosol] (R-HSA-2530599) p-S195-NEK7 [cytosol] (R-HSA-2984246)	0.556	3
UniProt:Q8WWW0 RASF5			0.556	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.527	2
UniProt:Q8TBJ4 PLPPR1	1	LPPR1 [plasma membrane] (R-HSA-6797625)	0.527	2
UniProt:Q9H813 PACC1			0.527	2
UniProt:P30550 GRPR	1	GRPR [plasma membrane] (R-HSA-375363)	0.527	2
UniProt:P47736 RAP1GAP	1	RAP1GAP [cytosol] (R-HSA-392493)	0.524	3

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