Reactome | CSNK2A1 [nucleoplasm]

CSNK2A1 [nucleoplasm]

Stable Identifier

R-HSA-6805057

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Casein kinase alpha subunit

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        M dimer is phosphorylated (Homo sapiens)
        
        CSN2KA dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSN2KA dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CK2 binds FACT (Homo sapiens)
        
        CK2:FACT [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSN2KA dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSN2KA dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CK2:FACT phosphorylates TP53 (Homo sapiens)
        
        CK2:FACT [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSN2KA dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSN2KA dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSN2KA dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSN2KA dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 dimer [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
        
        CSNK2A1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68400 CSNK2A1

Gene Names

CSNK2A1, CK2A1

Chain

chain:1-391

Reference Genes

BioGPS Gene:1457 CSNK2A1

COSMIC (genes):CSNK2A1 CSNK2A1

CTD Gene:1457 CSNK2A1

dbSNP Gene:1457 CSNK2A1

ENSEMBL:ENSG00000101266 CSNK2A1

HGNC:2457 CSNK2A1

KEGG:hsa:1457 CSNK2A1

Monarch:1457 CSNK2A1

NCBI Gene:1457 CSNK2A1

OMIM:115440 CSNK2A1

UCSC:P68400 CSNK2A1

Reference Transcript

Other Identifiers

11733783_a_at

11740086_a_at

11740087_s_at

11762083_at

1457

1567014_PM_s_at

1567014_s_at

16916328

206075_PM_s_at

206075_s_at

212072_PM_s_at

212072_s_at

212073_PM_at

212073_at

212075_PM_s_at

212075_s_at

239228_PM_at

239228_at

3363201

3363202

3363203

3363204

3363205

36235_at

3894222

3894223

3894225

3894227

3894229

3894230

3894231

3894232

3894233

3894234

3894235

3894236

3894237

3894238

3894239

3894240

3894241

3894242

3894243

3894244

3894245

3894247

3894248

3894249

3894250

3894251

3894252

3894253

3894254

3894255

3894256

3894257

3894258

3894259

3894260

3894261

3894262

3894263

3894264

3894265

3894266

3894267

3894268

3894269

3894273

3894277

3894278

3894280

3894281

3894282

3894284

3894285

40258_at

594_s_at

60425_at

74832_at

79137_at

7946655

8064351

A_21_P0009995

A_23_P502575

A_24_P57324

GE56193

GE611140

GE63191

GE744884

GE85926

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0005956

GO:0006281

GO:0006302

GO:0006457

GO:0006468

GO:0006915

GO:0006974

GO:0007165

GO:0008284

GO:0012501

GO:0016055

GO:0016301

GO:0016605

GO:0016740

GO:0017148

GO:0018105

GO:0018107

GO:0030177

GO:0030307

GO:0031519

GO:0032435

GO:0042802

GO:0043154

GO:0043226

GO:0043231

GO:0045732

GO:0048511

GO:0050821

GO:0051726

GO:0051879

GO:0061077

GO:0070822

GO:0075342

GO:0106310

GO:0140096

GO:1905337

GO:1905818

GO:2000042

GO:2001234

HMNXSV003000295

HMNXSV003025661

HMNXSV003055623

Hs.155140.3.S1_3p_a_at

Hs.155140.3.S2_3p_at

Hs.155140.3.S3_3p_at

Hs.292385.0.A1_3p_at

Hs2.406403.1.A1_3p_s_at

ILMN_1679501

ILMN_2386354

ILMN_2386355

M55265_at

PH_hs_0015168

PH_hs_0026100

TC11001423.hg

TC11003057.hg

TC20000542.hg

TC20001368.hg

TC20001369.hg

g4503094_3p_a_at

p21354

Participates

as a component of

Other forms of this molecule

CSNK2A1 [cytosol]

Inferred To

Homologues of CSNK2A1 [nucleoplasm] (Saccharomyces cerevisiae)

CSNK2A1 [nucleoplasm] (Bos taurus)

CSNK2A1 [nucleoplasm] (Caenorhabditis elegans)

CSNK2A1 [nucleoplasm] (Canis familiaris)

CSNK2A1 [nucleoplasm] (Dictyostelium discoideum)

CSNK2A1 [nucleoplasm] (Drosophila melanogaster)

CSNK2A1 [nucleoplasm] (Gallus gallus)

CSNK2A1 [nucleoplasm] (Mus musculus)

CSNK2A1 [nucleoplasm] (Plasmodium falciparum)

CSNK2A1 [nucleoplasm] (Rattus norvegicus)

CSNK2A1 [nucleoplasm] (Saccharomyces cerevisiae)

CSNK2A1 [nucleoplasm] (Schizosaccharomyces pombe)

CSNK2A1 [nucleoplasm] (Sus scrofa)

CSNK2A1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001886.1, NP_808227.1, NP_808228.1

ZINC - World Drugs

CSK21_HUMAN

Guide to Pharmacology - Targets

1549

OpenTargets

ENSG00000101266

ENSEMBL

ENST00000644003, ENST00000646477, ENST00000349736, ENST00000646305, ENST00000646561, ENST00000645623, ENST00000643660, ENSP00000495422, ENSP00000339247, ENSP00000495998, ENSP00000496569, ENSP00000495248, ENSP00000495902, ENSP00000495439, ENSP00000495912, ENSP00000217244, ENST00000646814, ENSP00000495387, ENST00000400217, ENSP00000383076, ENST00000217244, ENST00000647348

ZINC - FDA approved

CSK21_HUMAN

ZINC - Substances

CSK21_HUMAN

ZINC - Biogenic

CSK21_HUMAN

ZINC target

P68400

PRO

P68400

GlyGen

P68400

PDB

5OUE, 1PJK, 7AYA, 7L1X, 7A4B, 7PSU, 5VIE, 6L23, 5MO6, 6RFF, 3NGA, 7A4Q, 4GUB, 6TLO, 7ZY0, 6YPJ, 3QA0, 8QWY, 5CVG, 5CLP, 5N9K, 6SPW, 5ZN0, 9EPV, 3NSZ, 9EPY, 8AE7, 7ZYD, 5MO7, 7Z39, 5ZN1, 7QGD, 3W8L, 3WIK, 6TEI, 5H8B, 8AEM, 5MMR, 4MD7, 5ONI, 6L1Z, 6L22, 5OS8, 6Z84, 5OWL, 6EHU, 8QWZ, 1NA7, 4RLL, 4UB7, 5MPJ, 5CVF, 3AT3, 5ZN4, 5OTS, 9EPW, 5CTP, 5OQU, 6HOU, 6GMD, 5M44, 7QGE, 5OSR, 5KWH, 7QGB, 6Q38, 5OTI, 3WIL, 4DGL, 5OUU, 4MD8, 5VIF, 4GYW, 3R0T, 8P07, 5MO5, 4IB5, 3U87, 6HME, 5CU4, 6YPK, 7B8H, 5OSP, 5MOV, 3AT4, 5OTL, 5ZN3, 6Z83, 9EQ0, 4KWP, 5OTR, 6RCB, 6HOP, 7ZYO, 3AMY, 5OTH, 7X4H, 8PVP, 3OWK, 4MD9, 7AY9, 5HGV, 3AXW, 4GYY, 5OS7, 7QUX, 6EHK, 5CSV, 5CSP, 5NQC, 5OT5, 5H8E, 5CU3, 7B8I, 6HBN, 6Q4Q, 6TLL, 3Q9W, 6GIH, 3U9C, 3MB6, 5OTO, 7ZYK, 6HOR, 7ZYR, 5MMF, 8PVO, 7ZY8, 3BQC, 4UBA, 3WOW, 6TLW, 6TLP, 8P05, 7ZY5, 6HNW, 2ZJW, 3Q04, 5MOD, 5CT0, 6RFE, 5N9L, 3H30, 6JWA, 5ORH, 5CVH, 5ZN5, 5OSZ, 5OTQ, 6RB1, 5M4C, 6YUM, 6EII, 9EPZ, 6A1C, 3OWL, 6YZH, 5OTZ, 8AEK, 3JUH, 5OUL, 3PE1, 5ORK, 6TLV, 5B0X, 6TLS, 3FWQ, 6YPH, 5MOT, 4NH1, 5OMY, 7ZWG, 5MOH, 6Z19, 3WAR, 5CU6, 7ZY2, 6FVG, 5MOW, 5OTP, 5OYF, 8C6M, 6YUL, 9EQ1, 6HOQ, 3Q9X, 3OWJ, 3PE2, 3RPS, 5M4F, 5CQU, 5OUM, 4GZ3, 8BGC, 5CS6, 5ORJ, 6L21, 6TLR, 5MOE, 5CX9, 6YPG, 5OSU, 5H8G, 7ZWE, 5OTY, 3C13, 5T1H, 5N9N, 6FVF, 5CU0, 7BU4, 3AT2, 5MP8, 3MB7, 3Q9Y, 7QGC, 6HOT, 8C6N, 7AT5, 3PE4, 6E37, 1JWH, 7A49, 6TLU, 8AEC, 7A4C, 3TAX, 6RCM, 2PVR, 5OWH, 5CSH, 5OSL, 8C5Q, 5OT6, 6QY7, 6L24, 5N1V, 5KU8, 6HNY, 4FBX, 5CU2, 3U4U, 5OTD, 6SPX, 6YPN, 5CQW, 5M4I, 3Q9Z, 5MO8, 9EPX, 4GRB, 5ZN2, 8C6L

ZINC - Investigational

CSK21_HUMAN

ZINC - Metabolites

CSK21_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000101266-CSNK2A1

Pharos - Targets

P68400

Orphanet

CSNK2A1

ZINC - Predictions - Purchasable

CSK21_HUMAN

HMDB Protein

HMDBP01433

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.848	7
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.77	5
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.759	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.759	4
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.742	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.688	3
UniProt:P35659 DEK	1	DEK [nucleoplasm] (R-HSA-5250643)	0.688	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.675	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.656	3
UniProt:P46100 ATRX	20	ATRX E288* [nucleoplasm] (R-HSA-9670958) ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX Q176 [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581)	0.643	3
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.643	3
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.643	5
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.643	4
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	3
UniProt:Q01105 SET	1	SET [nucleoplasm] (R-HSA-451201)	0.59	2
UniProt:O00170 AIP	2	AIP [nucleoplasm] (R-HSA-8937156) AIP [cytosol] (R-HSA-8936839)	0.59	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.59	2
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.59	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.59	2
UniProt:Q9H063 MAF1	3	p-S60,S68,S75-MAF1 [cytosol] (R-HSA-8944455) MAF1 [cytosol] (R-HSA-8944460) MAF1 [nucleoplasm] (R-HSA-8944422)	0.59	2
UniProt:Q96GA3 LTV1	2	LTV1 [cytosol] (R-HSA-6791520) LTV1 [nucleoplasm] (R-HSA-6791566)	0.59	2
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.59	3
UniProt:Q92504 SLC39A7	1	SLC39A7 [endoplasmic reticulum membrane] (R-HSA-442363)	0.589	4
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.564	2
UniProt:P78563 ADARB1	1	ADARB1 [nucleoplasm] (R-HSA-62915)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	5
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.556	3
UniProt:O43623 SNAI2	1	SNAI2 [nucleoplasm] (R-HSA-2980898)	0.556	3
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.544	2
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.527	2
UniProt:O15541 RNF113A	1	RNF113A [nucleoplasm] (R-HSA-9769563)	0.527	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.527	2
UniProt:P16383 GCFC2	1	GCFC2 [nucleoplasm] (R-HSA-8869311)	0.527	2
UniProt:Q9NYV4 CDK12	1	CDK12 [nucleoplasm] (R-HSA-6797012)	0.527	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.527	2
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	2
UniProt:Q03164 KMT2A	6	KMT2A [cytosol] (R-HSA-9818584) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593)	0.527	2
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.527	2
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	3
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.527	2

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