Reactome | CK2:FACT phosphorylates TP53

CK2:FACT phosphorylates TP53

Stable Identifier

R-HSA-6805059

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CK2:FACT phosphorylates TP53 (Homo sapiens)

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Casein kinase II (CK2), associated with the FACT2 complex, phosphorylates TP53 (p53) at serine residue S392, enhancing transcriptional activity of TP53 in response to UV irradiation (Keller et al. 2001, Keller and Lu 2002).

Literature References

PubMed ID	Title	Journal	Year
12393879	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex Lu, H, Keller, DM	J. Biol. Chem.	2002
11239457	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1 Goodman, R, Shu, H, Lu, H, Zhao, Y, Kapoor, M, Zhang, QH, Keller, DM, Lozano, G, Wang, Y, Zeng, X	Mol. Cell	2001