Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CSNK2A2 [nucleoplasm]
Stable Identifier
R-HSA-6805065
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Casein kinase alpha' subunit
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Maturation of hRSV A proteins (Homo sapiens)
M dimer is phosphorylated (Homo sapiens)
CSN2KA dimer [nucleoplasm] (Homo sapiens)
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
Casein kinase II [nucleoplasm] (Homo sapiens)
CSN2KA dimer [nucleoplasm] (Homo sapiens)
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
CK2 binds FACT (Homo sapiens)
CK2:FACT [nucleoplasm] (Homo sapiens)
Casein kinase II [nucleoplasm] (Homo sapiens)
CSN2KA dimer [nucleoplasm] (Homo sapiens)
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
Casein kinase II [nucleoplasm] (Homo sapiens)
CSN2KA dimer [nucleoplasm] (Homo sapiens)
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CK2:FACT phosphorylates TP53 (Homo sapiens)
CK2:FACT [nucleoplasm] (Homo sapiens)
Casein kinase II [nucleoplasm] (Homo sapiens)
CSN2KA dimer [nucleoplasm] (Homo sapiens)
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
Casein kinase II [nucleoplasm] (Homo sapiens)
CSN2KA dimer [nucleoplasm] (Homo sapiens)
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
Casein kinase II [nucleoplasm] (Homo sapiens)
CSN2KA dimer [nucleoplasm] (Homo sapiens)
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
Casein kinase II [nucleoplasm] (Homo sapiens)
CSN2KA dimer [nucleoplasm] (Homo sapiens)
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
CSNK2A2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19784 CSNK2A2
Gene Names
CSNK2A2, CK2A2
Chain
chain:1-350
Reference Genes
BioGPS Gene:1459 CSNK2A2
COSMIC (genes):CSNK2A2 CSNK2A2
CTD Gene:1459 CSNK2A2
dbSNP Gene:1459 CSNK2A2
ENSEMBL:ENSG00000070770 CSNK2A2
HGNC:2459 CSNK2A2
KEGG:hsa:1459 CSNK2A2
Monarch:1459 CSNK2A2
NCBI Gene:1459 CSNK2A2
OMIM:115442 CSNK2A2
UCSC:P19784 CSNK2A2
Reference Transcript
RefSeq:NM_001896.2 CSNK2A2
Other Identifiers
11716807_a_at
11763321_at
11763322_s_at
1459
16826879
16826892
203575_PM_at
203575_at
224922_PM_at
224922_at
3693534
3693535
3693536
3693537
3693538
3693539
3693540
3693541
3693542
3693543
3693544
3693545
3693546
3693547
3693549
3693550
3693552
3693553
3693554
3693555
3693556
3693557
3693558
3693560
3693561
3693564
3693567
3693569
3693570
3693571
3693572
3693573
37629_at
42076_at
48065_at
50900_at
50902_g_at
64241_r_at
8001666
ADDON000315.hg
ADDON002190.hg
A_21_P0014329
A_23_P14915
A_24_P934809
GE57970
GO:0000785
GO:0001669
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005956
GO:0006281
GO:0006302
GO:0006468
GO:0006915
GO:0007283
GO:0012501
GO:0016055
GO:0016740
GO:0021987
GO:0022414
GO:0031410
GO:0031519
GO:0032435
GO:0043226
GO:0048856
GO:0051726
GO:0097421
GO:0106310
GO:0140096
GO:1901524
GO:1903955
GO:1905818
GO:2001234
HMNXSV003020620
HMNXSV003037668
Hs.237955.6.S1_3p_at
ILMN_1696468
ILMN_1723843
M55268_at
PH_hs_0039556
TC16001148.hg
TC16001149.hg
g4503096_3p_at
p25966
Participates
as a component of
CSNK2A1:CSNK2A2 [nucleoplasm] (Homo sapiens)
CSNK2A2 dimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CSNK2A2 [cytosol]
Inferred To
Homologues of CSNK2A2 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of CSNK2A2 [nucleoplasm]
(Plasmodium falciparum)
Homologues of CSNK2A2 [nucleoplasm]
(Saccharomyces cerevisiae)
CSNK2A2 [nucleoplasm]
(Bos taurus)
CSNK2A2 [nucleoplasm]
(Caenorhabditis elegans)
CSNK2A2 [nucleoplasm]
(Canis familiaris)
CSNK2A2 [nucleoplasm]
(Dictyostelium discoideum)
CSNK2A2 [nucleoplasm]
(Drosophila melanogaster)
CSNK2A2 [nucleoplasm]
(Gallus gallus)
CSNK2A2 [nucleoplasm]
(Mus musculus)
CSNK2A2 [nucleoplasm]
(Plasmodium falciparum)
CSNK2A2 [nucleoplasm]
(Rattus norvegicus)
CSNK2A2 [nucleoplasm]
(Saccharomyces cerevisiae)
CSNK2A2 [nucleoplasm]
(Schizosaccharomyces pombe)
CSNK2A2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001887.1
ZINC - World Drugs
CSK22_HUMAN
Guide to Pharmacology - Targets
1550
OpenTargets
ENSG00000070770
ENSEMBL
ENST00000262506
,
ENSP00000262506
ZINC - FDA approved
CSK22_HUMAN
ZINC - Substances
CSK22_HUMAN
ZINC - Biogenic
CSK22_HUMAN
ZINC target
P19784
PRO
P19784
GlyGen
P19784
PDB
7A22
,
6TE2
,
6HMB
,
7A1Z
,
7ATV
,
6HMC
,
6HMD
,
3E3B
,
6TGU
,
7XYH
,
3OFM
,
8QCG
,
6TEW
,
8QF1
,
6HMQ
,
7A2H
,
5Y9M
,
8QBU
,
8Q77
,
8QCD
,
5YF9
,
3U87
,
7A1B
,
5M56
,
5M4U
,
6QY8
,
8Q9S
,
6L20
,
7AT9
,
5YWM
,
6QY9
,
5OOI
ZINC - Investigational
CSK22_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000070770-CSNK2A2
Pharos - Targets
P19784
ZINC - Predictions - Purchasable
CSK22_HUMAN
HMDB Protein
HMDBP01476
Interactors (25)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.725
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.725
4
UniProt:Q8N5F7 NKAP
1
NKAP [nucleoplasm]
(R-HSA-9769602)
0.725
7
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.725
5
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.725
4
UniProt:P35659 DEK
1
DEK [nucleoplasm]
(R-HSA-5250643)
0.643
3
UniProt:Q9UJV9 DDX41
4
DDX41 [nucleoplasm]
(R-HSA-9769601)
DDX41 [cytosol]
(R-HSA-3134807)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134942)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134941)
0.643
3
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.643
3
UniProt:Q9H2G4 TSPYL2
1
TSPYL2 [nucleoplasm]
(R-HSA-535540)
0.643
4
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.643
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
5
UniProt:Q99873 PRMT1
2
PRMT1 [nucleoplasm]
(R-HSA-3215140)
PRMT1 [cytosol]
(R-HSA-9632173)
0.527
2
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.527
2
UniProt:O15541 RNF113A
1
RNF113A [nucleoplasm]
(R-HSA-9769563)
0.527
2
UniProt:P16383 GCFC2
1
GCFC2 [nucleoplasm]
(R-HSA-8869311)
0.527
2
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.527
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.527
2
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.527
2
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.527
2
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.527
2
UniProt:O15160 POLR1C
2
POLR1C [cytosol]
(R-HSA-1964454)
POLR1C [nucleoplasm]
(R-HSA-63498)
0.527
2
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.527
2
UniProt:Q2NL82 TSR1
2
TSR1 [nucleoplasm]
(R-HSA-6791574)
TSR1 [cytosol]
(R-HSA-6791570)
0.527
2
UniProt:P46100 ATRX
20
ATRX E288* [nucleoplasm]
(R-HSA-9670958)
ATRX K329Ifs*3 [nucleoplasm]
(R-HSA-9672232)
ATRX Q176* [nucleoplasm]
(R-HSA-9671592)
ATRX C268Qfs*18 [nucleoplasm]
(R-HSA-9672233)
ATRX Q177* [nucleoplasm]
(R-HSA-9671589)
ATRX K330Nfs*2 [nucleoplasm]
(R-HSA-9672231)
ATRX G161* [nucleoplasm]
(R-HSA-9671266)
ATRX Q176Hfs*13 [nucleoplasm]
(R-HSA-9671806)
ATRX R160Pfs*29 [nucleoplasm]
(R-HSA-9671801)
ATRX K319* [nucleoplasm]
(R-HSA-9671669)
ATRX W222* [nucleoplasm]
(R-HSA-9671670)
ATRX E63* [nucleoplasm]
(R-HSA-9670961)
ATRX S79* [nucleoplasm]
(R-HSA-9671244)
ATRX H166Mfs*4 [nucleoplasm]
(R-HSA-9672205)
ATRX Y266* [nucleoplasm]
(R-HSA-9671624)
ATRX L253* [nucleoplasm]
(R-HSA-9671688)
ATRX W263* [nucleoplasm]
(R-HSA-9671685)
ATRX Y187* [nucleoplasm]
(R-HSA-9671622)
ATRX Y204* [nucleoplasm]
(R-HSA-9671619)
ATRX Q292* [nucleoplasm]
(R-HSA-9671581)
0.527
2
UniProt:P06748 NPM1
11
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [granular component]
(R-HSA-9017702)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
