AURKB phosphorylates TP53

Stable Identifier
R-HSA-6805126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AURKB phosphorylates TP53
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AURKB (Aurora kinase B) phosphorylates TP53 (p53) at serine residue S269 and threonine residue T284, which inhibits TP53 transcriptional activity (Wu et al. 2011).

Literature References
PubMed ID Title Journal Year
20959462 Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression

Wu, L, Zhao, Y, Jain, A, Ma, CA

J. Biol. Chem. 2011
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Catalyst Activity

protein serine/threonine kinase activity of AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm]

Physical Entity
AURKB:NOC2L:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AURKB phosphorylates TP53 (Bos taurus)
AURKB phosphorylates TP53 (Canis familiaris)
AURKB phosphorylates TP53 (Danio rerio)
AURKB phosphorylates TP53 (Drosophila melanogaster)
AURKB phosphorylates TP53 (Mus musculus)
AURKB phosphorylates TP53 (Rattus norvegicus)
AURKB phosphorylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-18)
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