Reactome | FIP1L1 [nucleoplasm]

FIP1L1 [nucleoplasm]

Stable Identifier

R-HSA-6805150

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Pre-mRNA 3'-end-processing factor FIP1, FIP1_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        FIP1L1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6UN15 FIP1L1

Gene Names

FIP1L1, FIP1, RHE

Chain

chain:1-594

Reference Genes

BioGPS Gene:81608 FIP1L1

COSMIC (genes):FIP1L1 FIP1L1

CTD Gene:81608 FIP1L1

dbSNP Gene:81608 FIP1L1

ENSEMBL:ENSG00000145216 FIP1L1

HGNC:19124 FIP1L1

KEGG:hsa:81608 FIP1L1

Monarch:81608 FIP1L1

NCBI Gene:81608 FIP1L1

OMIM:607686 FIP1L1

UCSC:Q6UN15 FIP1L1

Reference Transcript

Participates

as an input of

Formation of the CPSF complex (Homo sapiens)

as a component of

This entity regulates

Positively

CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS (Homo sapiens)

Other forms of this molecule

FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]

FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol]

FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]

FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]

p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]

p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]

p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]

p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]

Inferred To

fipp-1 [nucleoplasm] (Caenorhabditis elegans)

Fip1 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of FIP1L1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of FIP1L1 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of FIP1L1 [nucleoplasm] (Danio rerio)

Fip1l1 [nucleoplasm] (Mus musculus)

Fip1l1 [nucleoplasm] (Rattus norvegicus)

fip1l1a [nucleoplasm] (Danio rerio)

fip1l1 [nucleoplasm] (Danio rerio)

fip1l1 [nucleoplasm] (Dictyostelium discoideum)

fip1l1 [nucleoplasm] (Xenopus tropicalis)

FIP1L1 [nucleoplasm] (Bos taurus)

FIP1L1 [nucleoplasm] (Canis familiaris)

FIP1L1 [nucleoplasm] (Gallus gallus)

FIP1L1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001128410.1, NP_112179.2, NP_001128409.1

OpenTargets

ENSG00000145216

ENSEMBL

ENSP00000336752, ENST00000306932, ENSG00000145216, ENSP00000351383, ENST00000703489, ENSP00000302993, ENSP00000425456, ENST00000507922, ENST00000337488, ENSP00000515339, ENST00000358575

HPA

ENSG00000145216-FIP1L1

GeneCards

FIP1L1

PRO

Q6UN15

Pharos - Targets

Q6UN15

GlyGen

Q6UN15

Orphanet

FIP1L1

PDB

7ZYH, 7K95, 7ZY4

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.659	5
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.564	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q06102	1	YTH1 [nucleoplasm] (R-SCE-169104)	0.556	3
UniProt:Q96E35 ZMY19			0.556	3
UniProt:P41227 NAA10			0.556	3
UniProt:Q9C0J8 WDR33	1	WDR33 [nucleoplasm] (R-HSA-8938784)	0.527	2
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.527	2
UniProt:Q9H0L4 CSTF2T	1	CSTF2T [nucleoplasm] (R-HSA-8938786)	0.527	2
UniProt:Q9P2I0 CPSF2	1	CPSF2 [nucleoplasm] (R-HSA-71991)	0.527	2
UniProt:Q9UKF6 CPSF3	2	Ub-K63-CPSF3 [nucleoplasm] (R-HSA-9970273) CPSF3 [nucleoplasm] (R-HSA-71993)	0.527	3
UniProt:P13674 P4HA1	1	P4HA1 [endoplasmic reticulum lumen] (R-HSA-2980917)	0.527	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2
UniProt:P0DTD1-PRO_0000449623 REP			0.482	2

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