Reactome | CDK5 phosphorylates TP53

CDK5 phosphorylates TP53

Stable Identifier

R-HSA-6805276

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CDK5 phosphorylates TP53 (Homo sapiens)

General

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CDK5, in complex with cleaved CDK5R1 (p25), which ensures nuclear localization (Patrick et al. 1999, Lee et al. 2008), phosphorylates TP53 (p53) on serine residues S15, S33 and S46. CDK5-mediated phosphorylation of TP53 promotes transcription of pro-apoptotic genes and neuronal cell death (Zhang et al. 2002, Lee et al. 2007, Lee et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
10604467	Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration Dikkes, P, Patrick, GN, Nikolic, M, Zukerberg, L, Tsai, LH, de la Monte, S	Nature	1999
17591690	Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death Kim, HS, Lee, SJ, Lee, JH, Kim, KT	J. Cell. Sci.	2007
12064478	Cdk5 phosphorylates p53 and regulates its activity Krishnamurthy, PK, Johnson, GV, Zhang, J	J. Neurochem.	2002
10500146	Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation Albers, RW, Sharma, M, Sharma, P, Pant, HC, Amin, ND	Proc. Natl. Acad. Sci. U.S.A.	1999
18490454	Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress Choi, YH, Lee, JH, Kim, KT, Kim, W, Jeong, MW	J. Biol. Chem.	2008