PLK3 phosphorylates TP53

Stable Identifier
R-HSA-6805285
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PLK3 phosphorylates TP53
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PLK3 contributes to stabilizing phosphorylation of TP53 on serine residue S20 (Xie, Wang et al. 2001, Xie, Wu et al. 2001).

Literature References
PubMed ID Title Journal Year
11551930 Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

Husain, I, Wang, Q, Stambrook, P, Dai, W, Wu, H, Xie, S, Conn, C, Cogswell, JP, Jhanwar-Uniyal, M

J. Biol. Chem. 2001
11447225 Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

Wang, Q, Dai, W, Wu, H, Lu, L, Xie, S, Cogswell, J, Jhanwar-Uniyal, M

J. Biol. Chem. 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of PLK3 [nucleoplasm]

Physical Entity
PLK3 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PLK3 phosphorylates TP53 (Bos taurus)
PLK3 phosphorylates TP53 (Canis familiaris)
PLK3 phosphorylates TP53 (Danio rerio)
PLK3 phosphorylates TP53 (Mus musculus)
PLK3 phosphorylates TP53 (Rattus norvegicus)
PLK3 phosphorylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-19)
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