Reactome | TP53RK phosphorylates TP53

TP53RK phosphorylates TP53

Stable Identifier

R-HSA-6805479

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        TP53RK phosphorylates TP53 (Homo sapiens)

General

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The atypical protein serine/threonine kinase TP53RK (TP53-regulating kinase), also known as PRPK (p53-related protein kinase), phosphorylates TP53 (p53) on serine residue S15 (Abe et al. 2001, Facchin et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11546806	Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes Nikawa, J, Abe, Y, Enomoto, Y, Matsumoto, S, Nezu, K, Wei, S, Ueda, N, Shigemoto, K, Miyoshi, A, Hitsumoto, Y, Kito, K	J. Biol. Chem.	2001
12914926	Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency Montenarh, M, Carignani, G, Ruzzene, M, Götz, C, Facchin, S, Sartori, G, Pinna, LA, Lopreiato, R, Marin, O	FEBS Lett.	2003