AKT phosphorylates KAT6A

Stable Identifier
R-HSA-6805640
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AKT phosphorylates KAT6A
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Activated AKT phosphorylates the histone acetyltransferase KAT6A on threonine residue T369, preventing association of PML with the KAT6A complex and repressing KAT6A-mediated acetylation of TP53 (p53) (Rokudai et al. 2013).

Literature References
PubMed ID Title Journal Year
23431171 MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Taya, Y, Rokudai, S, Prives, C, Arnal, SM, Laptenko, O, Kitabayashi, I

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]

Physical Entity
p-T,p-S-AKT [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT phosphorylates KAT6A (Canis familiaris)
AKT phosphorylates KAT6A (Danio rerio)
AKT phosphorylates KAT6A (Dictyostelium discoideum)
AKT phosphorylates KAT6A (Drosophila melanogaster)
AKT phosphorylates KAT6A (Gallus gallus)
AKT phosphorylates KAT6A (Mus musculus)
AKT phosphorylates KAT6A (Rattus norvegicus)
AKT phosphorylates KAT6A (Schizosaccharomyces pombe)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-20)
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