MTA2-NuRD complex deacetylates TP53

Stable Identifier
R-HSA-6805650
Type
Reaction
Species
Homo sapiens
Compartment
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MTA2 (PID), a component of the NuRD complex, binds TP53 (p53) and thus targets histone deacetylases of the NuRD complex to TP53. The NuRD complex deacetylates the C-terminus of TP53, including acetylated lysine K382, thus inhibiting TP53 transcriptional activity (Luo et al. 2000).

Literature References
PubMed ID Title Journal Year
11099047 Deacetylation of p53 modulates its effect on cell growth and apoptosis

Su, F, Shiloh, A, Gu, W, Chen, D, Luo, J

Nature 2000
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Catalyst Activity

histone deacetylase activity of MTA2-NuRD complex [nucleoplasm]

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