Reactome | SETD9 methylates TP53

SETD9 methylates TP53

Stable Identifier

R-HSA-6805730

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        SETD9 methylates TP53 (Homo sapiens)

General

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The lysine methyltransferase SETD9 methylates TP53 (p53) on lysine residue K372. Methylation at K372 increases stability of TP53 and promotes transcription of TP53 target genes CDKN1A (p21), BAX and MDM2 (Chuikov et al. 2004, Couture et al. 2006). SETD9 may both mono- and dimethylate TP53 (Bai et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
16415881	Structural basis for the methylation site specificity of SET7/9 Couture, JF, Hauk, G, Trievel, RC, Collazo, E	Nat. Struct. Mol. Biol.	2006
15525938	Regulation of p53 activity through lysine methylation Kurash, JK, Reinberg, D, Gamblin, SJ, Wilson, JR, Prives, C, Xiao, B, Chuikov, S, Barlev, NA, Tempst, P, McKinney, K, Ivanov, GS, Justin, N	Nature	2004
21625555	Modeling a new water channel that allows SET9 to dimethylate p53 Yang, J, Wang, Q, Hai, J, Bai, Q, Du, Y, Jin, N, Hu, T, Wang, F, Yao, X, Shen, Y	PLoS ONE	2011