Reactome | p-S291-PHF20 [nucleoplasm]

p-S291-PHF20 [nucleoplasm]

Stable Identifier

R-HSA-6805776

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
        
        AKT phosphorylates PHF20 (Homo sapiens)
        
        p-S291-PHF20 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BVI0 PHF20

Gene Names

PHF20, C20orf104, GLEA2, HCA58, NZF, TZP

Chain

chain:1-1012

Reference Genes

BioGPS Gene:51230 PHF20

COSMIC (genes):PHF20 PHF20

CTD Gene:51230 PHF20

dbSNP Gene:51230 PHF20

ENSEMBL:ENSG00000025293 PHF20

ENSEMBL_homo_sapiens_GENE:ENSG00000025293.17 PHF20

HGNC:16098 PHF20

KEGG Gene (Homo sapiens):51230 PHF20

Monarch:51230 PHF20

NCBI Gene:51230 PHF20

OMIM:610335 PHF20

UCSC:Q9BVI0 PHF20

Reference Transcript

Other Identifiers

11736332_a_at

11736333_at

11755404_a_at

1569906_PM_s_at

1569906_s_at

16913206

206567_PM_s_at

206567_s_at

209422_PM_at

209422_at

209423_PM_s_at

209423_s_at

32884_at

35050_at

3883550

3883556

3883557

3883571

3883573

3883575

3883576

3883578

3883579

3883580

3883581

3883583

3883584

3883585

3883586

3883600

3883601

3883605

3883606

3883607

3883608

3883611

3883618

3883621

3883622

3883627

3883628

3883629

3883630

3883631

3883636

50384_s_at

51230

51684_at

59343_at

59345_at

59348_g_at

77574_at

8062213

A_14_P103587

A_23_P210969

A_23_P428835

A_24_P181944

A_24_P297098

GE62860

GE811791

GO:0000123

GO:0003677

GO:0005515

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005829

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0031965

GO:0036211

GO:0043226

GO:0044545

GO:0045893

GO:0046872

GO:0051571

GO:0071339

HMNXSV003006218

Hs.112594.0.S3_3p_at

Hs2.434248.1.S1_3p_s_at

ILMN_1813657

L09749_at

PH_hs_0015507

TC20000260.hg

g13195150_3p_a_at

g7705990_3p_s_at

Participates

as an output of

AKT phosphorylates PHF20 (Homo sapiens)

Other forms of this molecule

PHF20 [nucleoplasm]

Inferred To

phospho-MBD-R2 [nucleoplasm] (Drosophila melanogaster)

phospho-Phf20 [nucleoplasm] (Mus musculus)

phospho-Phf20 [nucleoplasm] (Rattus norvegicus)

phospho-PHF20 [nucleoplasm] (Bos taurus)

phospho-PHF20 [nucleoplasm] (Canis familiaris)

phospho-PHF20 [nucleoplasm] (Gallus gallus)

phospho-PHF20 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 291

Coordinate

291

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016883353.1, XP_016883355.1, NP_057520.2, XP_016883354.1, XP_016883356.1

OpenTargets

ENSG00000025293

GeneCards

Q9BVI0

HPA

ENSG00000025293-PHF20

Ensembl

ENSG00000025293, ENST00000374012, ENSP00000363124

PRO

Q9BVI0

Pharos - Targets

Q9BVI0

PDB

5TBN, 5TAB, 2LDM, 3P8D, 3QII, 3SD4, 3Q1J

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.655	6
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.643	3
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.618	3
UniProt:Q15678 PTPN14	1	PTPN14 [nucleoplasm] (R-HSA-9008917)	0.527	2
UniProt:Q7Z3B3 KANSL1	1	KANSL1 [nucleoplasm] (R-HSA-3321875)	0.527	3
UniProt:Q9H9L4 KANSL2	1	KANSL2 [nucleoplasm] (R-HSA-3321796)	0.527	2
UniProt:Q9P2N6 KANSL3	1	KANSL3 [nucleoplasm] (R-HSA-3321882)	0.499	2
UniProt:Q5NCY0 Kdm6b	2	Kdm6b [nucleoplasm] (R-MMU-9822927) KDM6B [nucleoplasm] (R-MMU-1629833)	0.488	2

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